Treatment with SI000413, a New Herbal Formula, Ameliorates Murine Collagen-Induced Arthritis
We tested the effects of SI000413, a new formula, consisting of Pyrolae herba and Trachelospermi caulis, on type II collagen-induced arthritis (CIA). CIA was induced in DBA/1J mice by immunization with bovine type II collagen (CII) on days 1 and 21. SI000413 was orally administered 3 times per week...
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| Veröffentlicht in: | Biological & pharmaceutical bulletin 2008/07/01, Vol.31(7), pp.1337-1342 |
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| creator | Park, Jee-Hun Lee, Jeong-Min Kim, Se-Na Lee, Seung-Ha Jun, Sung-Hoon You, Jae-Hoon Ahn, Kyoo-Seok Kang, Hee |
| description | We tested the effects of SI000413, a new formula, consisting of Pyrolae herba and Trachelospermi caulis, on type II collagen-induced arthritis (CIA). CIA was induced in DBA/1J mice by immunization with bovine type II collagen (CII) on days 1 and 21. SI000413 was orally administered 3 times per week throughout the experiment and indomethacin was served as a positive control. Clinical scores, the count of arthritic legs, levels of interleukin 6 (IL-6) and anti-CII antibody, and lymphocyte subsets in blood were examined. SI000413 suppressed CIA development in a dose dependent manner and reduced the incidence of arthritic legs in mice. Histological analysis showed administration of SI000413 reduced inflammatory signs and cartilage destruction. Serum levels of IL-6 and anti-CII antibody were significantly decreased in SI000413-treated mice and the percentages of CD4 T cell, CD8 T cell and B cell in blood were restored to normal levels. In conclusion, we demonstrate that SI000413 ameliorates CIA both clinically and histologically and inhibits the production of anti-CII antibody and pro-inflammatory cytokine in the CIA mouse. These findings suggest that SI000413 is a potential new therapeutic herbal formula for the treatment of RA. |
| doi_str_mv | 10.1248/bpb.31.1337 |
| format | Article |
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CIA was induced in DBA/1J mice by immunization with bovine type II collagen (CII) on days 1 and 21. SI000413 was orally administered 3 times per week throughout the experiment and indomethacin was served as a positive control. Clinical scores, the count of arthritic legs, levels of interleukin 6 (IL-6) and anti-CII antibody, and lymphocyte subsets in blood were examined. SI000413 suppressed CIA development in a dose dependent manner and reduced the incidence of arthritic legs in mice. Histological analysis showed administration of SI000413 reduced inflammatory signs and cartilage destruction. Serum levels of IL-6 and anti-CII antibody were significantly decreased in SI000413-treated mice and the percentages of CD4 T cell, CD8 T cell and B cell in blood were restored to normal levels. In conclusion, we demonstrate that SI000413 ameliorates CIA both clinically and histologically and inhibits the production of anti-CII antibody and pro-inflammatory cytokine in the CIA mouse. These findings suggest that SI000413 is a potential new therapeutic herbal formula for the treatment of RA.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.31.1337</identifier><identifier>PMID: 18591771</identifier><language>eng</language><publisher>Japan: The Pharmaceutical Society of Japan</publisher><subject>Animals ; Antirheumatic Agents - chemistry ; Antirheumatic Agents - pharmacology ; Arthritis, Rheumatoid - chemically induced ; Arthritis, Rheumatoid - pathology ; Arthritis, Rheumatoid - prevention & control ; Autoantibodies - analysis ; Autoantibodies - biosynthesis ; Cartilage - pathology ; CD4-Positive T-Lymphocytes - drug effects ; CD8-Positive T-Lymphocytes - drug effects ; Chromatography, High Pressure Liquid ; collagen induced arthritis ; Collagen Type II - immunology ; Cytokines - metabolism ; Dose-Response Relationship, Drug ; Flow Cytometry ; Furans - analysis ; Furans - isolation & purification ; Glucosides - analysis ; Glucosides - isolation & purification ; IL-6 ; Interleukin-6 - analysis ; Interleukin-6 - biosynthesis ; Joints - pathology ; Lymphocyte Subsets - immunology ; Male ; Mice ; Mice, Inbred DBA ; Plant Extracts - chemistry ; Plant Extracts - pharmacology ; Plant Preparations - chemistry ; Plant Preparations - pharmacology ; Pyrolae herba ; Trachelospermi caulis</subject><ispartof>Biological and Pharmaceutical Bulletin, 2008/07/01, Vol.31(7), pp.1337-1342</ispartof><rights>2008 The Pharmaceutical Society of Japan</rights><rights>Copyright Japan Science and Technology Agency 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-d1110988b66ccb2b794824501b1cc5d1cc7f83bcbf337c39306b5a55a982f7b93</citedby><cites>FETCH-LOGICAL-c499t-d1110988b66ccb2b794824501b1cc5d1cc7f83bcbf337c39306b5a55a982f7b93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18591771$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Park, Jee-Hun</creatorcontrib><creatorcontrib>Lee, Jeong-Min</creatorcontrib><creatorcontrib>Kim, Se-Na</creatorcontrib><creatorcontrib>Lee, Seung-Ha</creatorcontrib><creatorcontrib>Jun, Sung-Hoon</creatorcontrib><creatorcontrib>You, Jae-Hoon</creatorcontrib><creatorcontrib>Ahn, Kyoo-Seok</creatorcontrib><creatorcontrib>Kang, Hee</creatorcontrib><title>Treatment with SI000413, a New Herbal Formula, Ameliorates Murine Collagen-Induced Arthritis</title><title>Biological & pharmaceutical bulletin</title><addtitle>Biol Pharm Bull</addtitle><description>We tested the effects of SI000413, a new formula, consisting of Pyrolae herba and Trachelospermi caulis, on type II collagen-induced arthritis (CIA). CIA was induced in DBA/1J mice by immunization with bovine type II collagen (CII) on days 1 and 21. SI000413 was orally administered 3 times per week throughout the experiment and indomethacin was served as a positive control. Clinical scores, the count of arthritic legs, levels of interleukin 6 (IL-6) and anti-CII antibody, and lymphocyte subsets in blood were examined. SI000413 suppressed CIA development in a dose dependent manner and reduced the incidence of arthritic legs in mice. Histological analysis showed administration of SI000413 reduced inflammatory signs and cartilage destruction. Serum levels of IL-6 and anti-CII antibody were significantly decreased in SI000413-treated mice and the percentages of CD4 T cell, CD8 T cell and B cell in blood were restored to normal levels. In conclusion, we demonstrate that SI000413 ameliorates CIA both clinically and histologically and inhibits the production of anti-CII antibody and pro-inflammatory cytokine in the CIA mouse. These findings suggest that SI000413 is a potential new therapeutic herbal formula for the treatment of RA.</description><subject>Animals</subject><subject>Antirheumatic Agents - chemistry</subject><subject>Antirheumatic Agents - pharmacology</subject><subject>Arthritis, Rheumatoid - chemically induced</subject><subject>Arthritis, Rheumatoid - pathology</subject><subject>Arthritis, Rheumatoid - prevention & control</subject><subject>Autoantibodies - analysis</subject><subject>Autoantibodies - biosynthesis</subject><subject>Cartilage - pathology</subject><subject>CD4-Positive T-Lymphocytes - drug effects</subject><subject>CD8-Positive T-Lymphocytes - drug effects</subject><subject>Chromatography, High Pressure Liquid</subject><subject>collagen induced arthritis</subject><subject>Collagen Type II - immunology</subject><subject>Cytokines - metabolism</subject><subject>Dose-Response Relationship, Drug</subject><subject>Flow Cytometry</subject><subject>Furans - analysis</subject><subject>Furans - isolation & purification</subject><subject>Glucosides - analysis</subject><subject>Glucosides - isolation & purification</subject><subject>IL-6</subject><subject>Interleukin-6 - analysis</subject><subject>Interleukin-6 - biosynthesis</subject><subject>Joints - pathology</subject><subject>Lymphocyte Subsets - immunology</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred DBA</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Preparations - chemistry</subject><subject>Plant Preparations - pharmacology</subject><subject>Pyrolae herba</subject><subject>Trachelospermi caulis</subject><issn>0918-6158</issn><issn>1347-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1PGzEQhi1UVALtiXtlqUfY1LO21_atUcRHJKCHwg3Jsr3eZqP9SG2vEP8eRwlweecwj97RPAidA5lDyeQvu7VzCnOgVByhGVAmCl4C_4JmRIEsKuDyBJ3GuCGECFLSr-gEJFcgBMzQ82PwJvV-SPilTWv8d5UpBvQSG_zgX_CtD9Z0-HoM_dSZS7zofdeOwSQf8f0U2sHj5dh15p8fitVQT87XeBHSOrSpjd_QcWO66L8f5hl6ur56XN4Wd39uVsvFXeGYUqmoAYAoKW1VOWdLKxSTJeMELDjH6xyikdQ62-QXHVWUVJYbzo2SZSOsomfo5753G8b_k49Jb8YpDPmkBsYUrVRZskxd7CkXxhiDb_Q2tL0JrxqI3pnU2aSmoHcmM_3j0DnZ3tef7EFdBn7vgU1M-f0PwITUus6_l4l97Do_Vm5tgvYDfQPkcYOF</recordid><startdate>20080701</startdate><enddate>20080701</enddate><creator>Park, Jee-Hun</creator><creator>Lee, Jeong-Min</creator><creator>Kim, Se-Na</creator><creator>Lee, Seung-Ha</creator><creator>Jun, Sung-Hoon</creator><creator>You, Jae-Hoon</creator><creator>Ahn, Kyoo-Seok</creator><creator>Kang, Hee</creator><general>The Pharmaceutical Society of Japan</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope></search><sort><creationdate>20080701</creationdate><title>Treatment with SI000413, a New Herbal Formula, Ameliorates Murine Collagen-Induced Arthritis</title><author>Park, Jee-Hun ; Lee, Jeong-Min ; Kim, Se-Na ; Lee, Seung-Ha ; Jun, Sung-Hoon ; You, Jae-Hoon ; Ahn, Kyoo-Seok ; Kang, Hee</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-d1110988b66ccb2b794824501b1cc5d1cc7f83bcbf337c39306b5a55a982f7b93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>Antirheumatic Agents - chemistry</topic><topic>Antirheumatic Agents - pharmacology</topic><topic>Arthritis, Rheumatoid - chemically induced</topic><topic>Arthritis, Rheumatoid - pathology</topic><topic>Arthritis, Rheumatoid - prevention & control</topic><topic>Autoantibodies - analysis</topic><topic>Autoantibodies - biosynthesis</topic><topic>Cartilage - pathology</topic><topic>CD4-Positive T-Lymphocytes - drug effects</topic><topic>CD8-Positive T-Lymphocytes - drug effects</topic><topic>Chromatography, High Pressure Liquid</topic><topic>collagen induced arthritis</topic><topic>Collagen Type II - immunology</topic><topic>Cytokines - metabolism</topic><topic>Dose-Response Relationship, Drug</topic><topic>Flow Cytometry</topic><topic>Furans - analysis</topic><topic>Furans - isolation & purification</topic><topic>Glucosides - analysis</topic><topic>Glucosides - isolation & purification</topic><topic>IL-6</topic><topic>Interleukin-6 - analysis</topic><topic>Interleukin-6 - biosynthesis</topic><topic>Joints - pathology</topic><topic>Lymphocyte Subsets - immunology</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred DBA</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Preparations - chemistry</topic><topic>Plant Preparations - pharmacology</topic><topic>Pyrolae herba</topic><topic>Trachelospermi caulis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Park, Jee-Hun</creatorcontrib><creatorcontrib>Lee, Jeong-Min</creatorcontrib><creatorcontrib>Kim, Se-Na</creatorcontrib><creatorcontrib>Lee, Seung-Ha</creatorcontrib><creatorcontrib>Jun, Sung-Hoon</creatorcontrib><creatorcontrib>You, Jae-Hoon</creatorcontrib><creatorcontrib>Ahn, Kyoo-Seok</creatorcontrib><creatorcontrib>Kang, Hee</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Biological & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Park, Jee-Hun</au><au>Lee, Jeong-Min</au><au>Kim, Se-Na</au><au>Lee, Seung-Ha</au><au>Jun, Sung-Hoon</au><au>You, Jae-Hoon</au><au>Ahn, Kyoo-Seok</au><au>Kang, Hee</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Treatment with SI000413, a New Herbal Formula, Ameliorates Murine Collagen-Induced Arthritis</atitle><jtitle>Biological & pharmaceutical bulletin</jtitle><addtitle>Biol Pharm Bull</addtitle><date>2008-07-01</date><risdate>2008</risdate><volume>31</volume><issue>7</issue><spage>1337</spage><epage>1342</epage><pages>1337-1342</pages><issn>0918-6158</issn><eissn>1347-5215</eissn><abstract>We tested the effects of SI000413, a new formula, consisting of Pyrolae herba and Trachelospermi caulis, on type II collagen-induced arthritis (CIA). CIA was induced in DBA/1J mice by immunization with bovine type II collagen (CII) on days 1 and 21. SI000413 was orally administered 3 times per week throughout the experiment and indomethacin was served as a positive control. Clinical scores, the count of arthritic legs, levels of interleukin 6 (IL-6) and anti-CII antibody, and lymphocyte subsets in blood were examined. SI000413 suppressed CIA development in a dose dependent manner and reduced the incidence of arthritic legs in mice. Histological analysis showed administration of SI000413 reduced inflammatory signs and cartilage destruction. Serum levels of IL-6 and anti-CII antibody were significantly decreased in SI000413-treated mice and the percentages of CD4 T cell, CD8 T cell and B cell in blood were restored to normal levels. In conclusion, we demonstrate that SI000413 ameliorates CIA both clinically and histologically and inhibits the production of anti-CII antibody and pro-inflammatory cytokine in the CIA mouse. These findings suggest that SI000413 is a potential new therapeutic herbal formula for the treatment of RA.</abstract><cop>Japan</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>18591771</pmid><doi>10.1248/bpb.31.1337</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Antirheumatic Agents - chemistry Antirheumatic Agents - pharmacology Arthritis, Rheumatoid - chemically induced Arthritis, Rheumatoid - pathology Arthritis, Rheumatoid - prevention & control Autoantibodies - analysis Autoantibodies - biosynthesis Cartilage - pathology CD4-Positive T-Lymphocytes - drug effects CD8-Positive T-Lymphocytes - drug effects Chromatography, High Pressure Liquid collagen induced arthritis Collagen Type II - immunology Cytokines - metabolism Dose-Response Relationship, Drug Flow Cytometry Furans - analysis Furans - isolation & purification Glucosides - analysis Glucosides - isolation & purification IL-6 Interleukin-6 - analysis Interleukin-6 - biosynthesis Joints - pathology Lymphocyte Subsets - immunology Male Mice Mice, Inbred DBA Plant Extracts - chemistry Plant Extracts - pharmacology Plant Preparations - chemistry Plant Preparations - pharmacology Pyrolae herba Trachelospermi caulis |
| title | Treatment with SI000413, a New Herbal Formula, Ameliorates Murine Collagen-Induced Arthritis |
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