WRN Functions in a RAD18-Dependent Damage Avoidance Pathway

Werner syndrome (WS), caused by mutations in a gene (WRN) that encodes a RecQ DNA helicase, is characterized by premature aging and cancer predisposition. Cells derived from WS patients show sensitivity to several DNA damaging agents. Previous studies revealed that the WRN protein plays roles in DNA...

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Veröffentlicht in:	Biological & Pharmaceutical Bulletin 2007, Vol.30(6), pp.1080-1083
Hauptverfasser:	Dong, Yu Peng, Seki, Masayuki, Yoshimura, Akari, Inoue, Eri, Furukawa, Shinya, Tada, Shusuke, Enomoto, Takemi
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Nitroquinoline-1-oxide - pharmacology Animals Cell Line Cell Proliferation Chickens Cisplatin - pharmacology DNA Damage DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism DT40 Electroporation Exodeoxyribonucleases Gene Targeting maintenance of genome stability 1 (Mgs1) Methyl Methanesulfonate - pharmacology Mutagens - pharmacology Proliferating Cell Nuclear Antigen proliferating cell nuclear antigen (PCNA) RAD18 Radiation-Sensitizing Agents - pharmacology RecQ RecQ Helicases - genetics RecQ Helicases - metabolism Sister Chromatid Exchange Ubiquitin-Protein Ligases Werner syndrome (WRN) Werner Syndrome - genetics Werner Syndrome - metabolism Werner Syndrome Helicase
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