Ability of Poly-L-arginine to Enhance Drug Absorption into Aqueous Humor and Vitreous Body after Instillation in Rabbits

The effect of poly-L-arginine with a molecular weight of 35.5 kDa (PLA) on the ocular absorption of hydrophilic molecules after instillation was examined in rabbits in vivo. FITC-labeled dextran (3.8 kDa, FD-4) and pyridoxamine were used as model hyprophilic molecules for absorption. The potential t...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2007/09/01, Vol.30(9), pp.1768-1772
Hauptverfasser:	Nemoto, Eiichi, Ueda, Hideo, Akimoto, Masayuki, Natsume, Hideshi, Morimoto, Yasunori
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorption absorption enhancer Animals Aqueous Humor - drug effects Aqueous Humor - metabolism Blotting, Western Chromatography, High Pressure Liquid Corneal Stroma - drug effects Corneal Stroma - metabolism Epithelium, Corneal - drug effects Epithelium, Corneal - metabolism inflammation Inflammation - pathology instillation Lipopolysaccharides - pharmacology Male Peptides - pharmacology Pharmaceutical Preparations - metabolism poly-L-arginine Rabbits Stimulation, Chemical Tumor Necrosis Factor-alpha - pharmacology Vitreous Body - drug effects Vitreous Body - metabolism
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