Checkpoint Kinase 1 Is Cleaved in a Caspase-Dependent Pathway during Genotoxic Stress-Induced Apoptosis

Checkpoint kinase 1 (Chk1) plays important roles in genotoxic stress-induced cell cycle checkpoint and in normal cell cycle progression. Here, we show that Chk1 is cleaved in the treatment of apoptotic dose of etoposide (ETP) or cisplatin (CIS) but not of viable dose in HeLa S3 cells. The cleavage o...

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