Stability and Cytotoxicity of Gambogic Acid and Its Derivative, Gambogoic Acid

In this study, the stability of gambogic acid (GA), a polyprenylated xanthone with potent cytotoxicities against various cancer cell lines, was evaluated under several experimental conditions including addition of acids, alkalis and organic solvents. GA was stable when dissolved in acetone, acetonit...

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Veröffentlicht in:	Biological & Pharmaceutical Bulletin 2005, Vol.28(12), pp.2335-2337
Hauptverfasser:	Han, Quan-Bin, Cheung, Susan, Tai, Joseph, Qiao, Chun-Feng, Song, Jing-Zheng, Xu, Hong-Xi
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemistry Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects Chromatography, High Pressure Liquid cytotoxicity Drug Screening Assays, Antitumor - methods Drug Stability gambogic acid gambogoic acid Garcinia hanburyi Humans Inhibitory Concentration 50 Methanol Resins, Plant - pharmacology Spectrometry, Mass, Electrospray Ionization stability Xanthones - chemistry Xanthones - isolation & purification Xanthones - pharmacology Xanthones - toxicity
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