Anti-inflammatory and Antitumor-Promoting Effects of the Triterpene Acids from the Leaves of Eriobotrya japonica
Sixteen triterpene acids, viz., five of the oleanane-type (1—5), nine of the ursane-type (6—14), and two of the lupane-type (15, 16), were isolated and identified from the ethyl acetate-soluble fraction of the methanol extract of the leaves of loquat, Eriobotrya japonica LINDL. (Rosaceae). Twelve of...
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| Veröffentlicht in: | Biological & pharmaceutical bulletin 2005, Vol.28(10), pp.1995-1999 |
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| container_issue | 10 |
| container_start_page | 1995 |
| container_title | Biological & pharmaceutical bulletin |
| container_volume | 28 |
| creator | Banno, Norihiro Akihisa, Toshihiro Tokuda, Harukuni Yasukawa, Ken Taguchi, Yosuke Akazawa, Hiroyuki Ukiya, Motohiko Kimura, Yumiko Suzuki, Takashi Nishino, Hoyoku |
| description | Sixteen triterpene acids, viz., five of the oleanane-type (1—5), nine of the ursane-type (6—14), and two of the lupane-type (15, 16), were isolated and identified from the ethyl acetate-soluble fraction of the methanol extract of the leaves of loquat, Eriobotrya japonica LINDL. (Rosaceae). Twelve of these compounds, 1—4, 6, 8—13, and 15, were evaluated for their inhibitory effects on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation (1 μg/ear) in mice. All the compounds tested showed a marked anti-inflammatory effect, with a 50% inhibitory dose (ID50) of 0.03—0.43 mg per ear. In addition, an evaluation against the Epstein-Barr virus early antigen (EBV-EA) activation induced by TPA for all of the compounds, 12 and 13 showed potent inhibitory effects on EBV-EA induction. Furthermore, euscaphic acid (12) exhibited marked antitumor-promoting activity in an in vivo two-stage carcinogenesis test of mouse tumor by using 7,12-dimethylbenz[a]anthracene (DMBA) as an initiator and TPA as a promoter. |
| doi_str_mv | 10.1248/bpb.28.1995 |
| format | Article |
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(Rosaceae). Twelve of these compounds, 1—4, 6, 8—13, and 15, were evaluated for their inhibitory effects on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation (1 μg/ear) in mice. All the compounds tested showed a marked anti-inflammatory effect, with a 50% inhibitory dose (ID50) of 0.03—0.43 mg per ear. In addition, an evaluation against the Epstein-Barr virus early antigen (EBV-EA) activation induced by TPA for all of the compounds, 12 and 13 showed potent inhibitory effects on EBV-EA induction. Furthermore, euscaphic acid (12) exhibited marked antitumor-promoting activity in an in vivo two-stage carcinogenesis test of mouse tumor by using 7,12-dimethylbenz[a]anthracene (DMBA) as an initiator and TPA as a promoter.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.28.1995</identifier><identifier>PMID: 16204964</identifier><language>eng</language><publisher>Japan: The Pharmaceutical Society of Japan</publisher><subject>Animals ; Anti-Inflammatory Agents - isolation & purification ; Anti-Inflammatory Agents - pharmacology ; anti-inflammatory effect ; Anticarcinogenic Agents - isolation & purification ; Anticarcinogenic Agents - pharmacology ; antitumor-promoting effect ; Chromatography, High Pressure Liquid ; Eriobotrya - chemistry ; Eriobotrya japonica ; Magnetic Resonance Spectroscopy ; Mice ; Papilloma - prevention & control ; Plant Leaves - chemistry ; Skin Neoplasms - prevention & control ; Spectrometry, Mass, Electrospray Ionization ; Tetradecanoylphorbol Acetate - pharmacology ; triterpene acid ; Triterpenes - isolation & purification ; Triterpenes - pharmacology ; two-stage skin carcinogenesis</subject><ispartof>Biological and Pharmaceutical Bulletin, 2005, Vol.28(10), pp.1995-1999</ispartof><rights>2005 The Pharmaceutical Society of Japan</rights><rights>Copyright Japan Science and Technology Agency 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c561t-4fa2cb192dba95ac2e3f425bb71918ed34d68c2ac08f8c5cba12f0e4e3ee75953</citedby><cites>FETCH-LOGICAL-c561t-4fa2cb192dba95ac2e3f425bb71918ed34d68c2ac08f8c5cba12f0e4e3ee75953</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1876,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16204964$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Banno, Norihiro</creatorcontrib><creatorcontrib>Akihisa, Toshihiro</creatorcontrib><creatorcontrib>Tokuda, Harukuni</creatorcontrib><creatorcontrib>Yasukawa, Ken</creatorcontrib><creatorcontrib>Taguchi, Yosuke</creatorcontrib><creatorcontrib>Akazawa, Hiroyuki</creatorcontrib><creatorcontrib>Ukiya, Motohiko</creatorcontrib><creatorcontrib>Kimura, Yumiko</creatorcontrib><creatorcontrib>Suzuki, Takashi</creatorcontrib><creatorcontrib>Nishino, Hoyoku</creatorcontrib><title>Anti-inflammatory and Antitumor-Promoting Effects of the Triterpene Acids from the Leaves of Eriobotrya japonica</title><title>Biological & pharmaceutical bulletin</title><addtitle>Biol Pharm Bull</addtitle><description>Sixteen triterpene acids, viz., five of the oleanane-type (1—5), nine of the ursane-type (6—14), and two of the lupane-type (15, 16), were isolated and identified from the ethyl acetate-soluble fraction of the methanol extract of the leaves of loquat, Eriobotrya japonica LINDL. (Rosaceae). Twelve of these compounds, 1—4, 6, 8—13, and 15, were evaluated for their inhibitory effects on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation (1 μg/ear) in mice. All the compounds tested showed a marked anti-inflammatory effect, with a 50% inhibitory dose (ID50) of 0.03—0.43 mg per ear. In addition, an evaluation against the Epstein-Barr virus early antigen (EBV-EA) activation induced by TPA for all of the compounds, 12 and 13 showed potent inhibitory effects on EBV-EA induction. 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Akihisa, Toshihiro ; Tokuda, Harukuni ; Yasukawa, Ken ; Taguchi, Yosuke ; Akazawa, Hiroyuki ; Ukiya, Motohiko ; Kimura, Yumiko ; Suzuki, Takashi ; Nishino, Hoyoku</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c561t-4fa2cb192dba95ac2e3f425bb71918ed34d68c2ac08f8c5cba12f0e4e3ee75953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Anti-Inflammatory Agents - isolation & purification</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>anti-inflammatory effect</topic><topic>Anticarcinogenic Agents - isolation & purification</topic><topic>Anticarcinogenic Agents - pharmacology</topic><topic>antitumor-promoting effect</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Eriobotrya - chemistry</topic><topic>Eriobotrya japonica</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Mice</topic><topic>Papilloma - prevention & control</topic><topic>Plant Leaves - chemistry</topic><topic>Skin Neoplasms - prevention & control</topic><topic>Spectrometry, Mass, Electrospray Ionization</topic><topic>Tetradecanoylphorbol Acetate - pharmacology</topic><topic>triterpene acid</topic><topic>Triterpenes - isolation & purification</topic><topic>Triterpenes - pharmacology</topic><topic>two-stage skin carcinogenesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Banno, Norihiro</creatorcontrib><creatorcontrib>Akihisa, Toshihiro</creatorcontrib><creatorcontrib>Tokuda, Harukuni</creatorcontrib><creatorcontrib>Yasukawa, Ken</creatorcontrib><creatorcontrib>Taguchi, Yosuke</creatorcontrib><creatorcontrib>Akazawa, Hiroyuki</creatorcontrib><creatorcontrib>Ukiya, Motohiko</creatorcontrib><creatorcontrib>Kimura, Yumiko</creatorcontrib><creatorcontrib>Suzuki, Takashi</creatorcontrib><creatorcontrib>Nishino, Hoyoku</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Biological & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Banno, Norihiro</au><au>Akihisa, Toshihiro</au><au>Tokuda, Harukuni</au><au>Yasukawa, Ken</au><au>Taguchi, Yosuke</au><au>Akazawa, Hiroyuki</au><au>Ukiya, Motohiko</au><au>Kimura, Yumiko</au><au>Suzuki, Takashi</au><au>Nishino, Hoyoku</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-inflammatory and Antitumor-Promoting Effects of the Triterpene Acids from the Leaves of Eriobotrya japonica</atitle><jtitle>Biological & pharmaceutical bulletin</jtitle><addtitle>Biol Pharm Bull</addtitle><date>2005-10-01</date><risdate>2005</risdate><volume>28</volume><issue>10</issue><spage>1995</spage><epage>1999</epage><pages>1995-1999</pages><issn>0918-6158</issn><eissn>1347-5215</eissn><abstract>Sixteen triterpene acids, viz., five of the oleanane-type (1—5), nine of the ursane-type (6—14), and two of the lupane-type (15, 16), were isolated and identified from the ethyl acetate-soluble fraction of the methanol extract of the leaves of loquat, Eriobotrya japonica LINDL. (Rosaceae). Twelve of these compounds, 1—4, 6, 8—13, and 15, were evaluated for their inhibitory effects on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation (1 μg/ear) in mice. All the compounds tested showed a marked anti-inflammatory effect, with a 50% inhibitory dose (ID50) of 0.03—0.43 mg per ear. In addition, an evaluation against the Epstein-Barr virus early antigen (EBV-EA) activation induced by TPA for all of the compounds, 12 and 13 showed potent inhibitory effects on EBV-EA induction. Furthermore, euscaphic acid (12) exhibited marked antitumor-promoting activity in an in vivo two-stage carcinogenesis test of mouse tumor by using 7,12-dimethylbenz[a]anthracene (DMBA) as an initiator and TPA as a promoter.</abstract><cop>Japan</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>16204964</pmid><doi>10.1248/bpb.28.1995</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Anti-Inflammatory Agents - isolation & purification Anti-Inflammatory Agents - pharmacology anti-inflammatory effect Anticarcinogenic Agents - isolation & purification Anticarcinogenic Agents - pharmacology antitumor-promoting effect Chromatography, High Pressure Liquid Eriobotrya - chemistry Eriobotrya japonica Magnetic Resonance Spectroscopy Mice Papilloma - prevention & control Plant Leaves - chemistry Skin Neoplasms - prevention & control Spectrometry, Mass, Electrospray Ionization Tetradecanoylphorbol Acetate - pharmacology triterpene acid Triterpenes - isolation & purification Triterpenes - pharmacology two-stage skin carcinogenesis |
| title | Anti-inflammatory and Antitumor-Promoting Effects of the Triterpene Acids from the Leaves of Eriobotrya japonica |
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