Correlation between Plasma Glucagon-Like Peptide 2 Levels and Proliferative Makers in Small Intestinal Injury in Rats Induced by Methotrexate Administration

Glucagon-like peptide 2 (GLP-2) is a potent intestinal epithelium-specific growth factor that has been shown to reduce the severity of inflammatory disorders of the intestine in rodent models. We examined whether a relationship exists between plasma level of GLP-2 and the degree of intestinal injury...

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Veröffentlicht in:	Biological & Pharmaceutical Bulletin 2006, Vol.29(11), pp.2327-2330
Hauptverfasser:	Hirotani, Yoshihiko, Yamamoto, Kaoru, Ikeda, Kenji, Arakawa, Yukio, Li, Jun, Kitamura, Kazuyuki, Kurokawa, Nobuo, Tanaka, Kazuhiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Biomarkers - analysis Cell Proliferation DNA - analysis Dose-Response Relationship, Drug Enzyme-Linked Immunosorbent Assay - methods glucagon-like peptide 2 Glucagon-Like Peptide 2 - blood intestinal injury Intestinal Mucosa - chemistry Intestinal Mucosa - drug effects Intestinal Mucosa - pathology Intestine, Small - chemistry Intestine, Small - drug effects Intestine, Small - pathology Membrane Proteins - analysis methotrexate Methotrexate - administration & dosage Methotrexate - blood Methotrexate - toxicity Mucositis - chemically induced Mucositis - metabolism plasma level Rats Weight Loss - drug effects
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