Relationship between Liver Injury and Transglutaminase Activities in Guinea Pigs and Rats
We investigated the effect of transglutaminase (TGase) on in guinea pigs and rats. Serum alanine aminotransferase (ALT) level increased 1 d after CCl4 treatment of both in guinea pigs and rats since TGaese activity was greatly higher in guinea pigs than rats. However, serum ALT level in guinea pigs...
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| Veröffentlicht in: | Biological & Pharmaceutical Bulletin 2004, Vol.27(2), pp.236-238 |
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| creator | Sato, Naoko Abe, Shinya Yamada, Takehito Iwasaki, Koichi Ohtake, Yosuke Ohkubo, Yasuhito |
| description | We investigated the effect of transglutaminase (TGase) on in guinea pigs and rats. Serum alanine aminotransferase (ALT) level increased 1 d after CCl4 treatment of both in guinea pigs and rats since TGaese activity was greatly higher in guinea pigs than rats. However, serum ALT level in guinea pigs was very much lower than that in rats. Liver TGase activities decreased after CCl4 treatment in both guinea pigs and rats. However, TGase activities in the liver from guinea pigs were higher than that from rats. Decreased TGase activities by CCl4 in the liver from guinea pigs and rats were significantly recovered by retinoic acid treatment that was reported to increase TGase. Degree of recovery of serum ALT level by retinoic acid in rats was larger than in guinea pigs. These results suggested that the distinction of the effect of retinoic acid on serum ALT level in CCl4-treated animals was due to the different TGase activity that increased membrane stability. |
| doi_str_mv | 10.1248/bpb.27.236 |
| format | Article |
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Serum alanine aminotransferase (ALT) level increased 1 d after CCl4 treatment of both in guinea pigs and rats since TGaese activity was greatly higher in guinea pigs than rats. However, serum ALT level in guinea pigs was very much lower than that in rats. Liver TGase activities decreased after CCl4 treatment in both guinea pigs and rats. However, TGase activities in the liver from guinea pigs were higher than that from rats. Decreased TGase activities by CCl4 in the liver from guinea pigs and rats were significantly recovered by retinoic acid treatment that was reported to increase TGase. Degree of recovery of serum ALT level by retinoic acid in rats was larger than in guinea pigs. These results suggested that the distinction of the effect of retinoic acid on serum ALT level in CCl4-treated animals was due to the different TGase activity that increased membrane stability.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.27.236</identifier><identifier>PMID: 14758042</identifier><language>eng</language><publisher>Japan: The Pharmaceutical Society of Japan</publisher><subject>Alanine Transaminase - blood ; Animals ; carbon tetrachloride (CCl4) ; Carbon Tetrachloride Poisoning - enzymology ; Chemical and Drug Induced Liver Injury - enzymology ; Chemical and Drug Induced Liver Injury - etiology ; guinea pig ; Guinea Pigs ; Male ; rat ; Rats ; Rats, Wistar ; retinoic acid ; Species Specificity ; transglutaminase (TGase) ; Transglutaminases - metabolism ; Tretinoin - pharmacology</subject><ispartof>Biological and Pharmaceutical Bulletin, 2004, Vol.27(2), pp.236-238</ispartof><rights>2004 The Pharmaceutical Society of Japan</rights><rights>Copyright Japan Science and Technology Agency 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c685t-164a691750fb9c2d3ff8a24bdd6c0196de2d431a95a4392a41de908e34406b1d3</citedby><cites>FETCH-LOGICAL-c685t-164a691750fb9c2d3ff8a24bdd6c0196de2d431a95a4392a41de908e34406b1d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14758042$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sato, Naoko</creatorcontrib><creatorcontrib>Abe, Shinya</creatorcontrib><creatorcontrib>Yamada, Takehito</creatorcontrib><creatorcontrib>Iwasaki, Koichi</creatorcontrib><creatorcontrib>Ohtake, Yosuke</creatorcontrib><creatorcontrib>Ohkubo, Yasuhito</creatorcontrib><creatorcontrib>Tohoku Pharmaceutical University</creatorcontrib><creatorcontrib>Department of Radiopharmacy</creatorcontrib><title>Relationship between Liver Injury and Transglutaminase Activities in Guinea Pigs and Rats</title><title>Biological & Pharmaceutical Bulletin</title><addtitle>Biol Pharm Bull</addtitle><description>We investigated the effect of transglutaminase (TGase) on in guinea pigs and rats. Serum alanine aminotransferase (ALT) level increased 1 d after CCl4 treatment of both in guinea pigs and rats since TGaese activity was greatly higher in guinea pigs than rats. However, serum ALT level in guinea pigs was very much lower than that in rats. Liver TGase activities decreased after CCl4 treatment in both guinea pigs and rats. However, TGase activities in the liver from guinea pigs were higher than that from rats. Decreased TGase activities by CCl4 in the liver from guinea pigs and rats were significantly recovered by retinoic acid treatment that was reported to increase TGase. Degree of recovery of serum ALT level by retinoic acid in rats was larger than in guinea pigs. These results suggested that the distinction of the effect of retinoic acid on serum ALT level in CCl4-treated animals was due to the different TGase activity that increased membrane stability.</description><subject>Alanine Transaminase - blood</subject><subject>Animals</subject><subject>carbon tetrachloride (CCl4)</subject><subject>Carbon Tetrachloride Poisoning - enzymology</subject><subject>Chemical and Drug Induced Liver Injury - enzymology</subject><subject>Chemical and Drug Induced Liver Injury - etiology</subject><subject>guinea pig</subject><subject>Guinea Pigs</subject><subject>Male</subject><subject>rat</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>retinoic acid</subject><subject>Species Specificity</subject><subject>transglutaminase (TGase)</subject><subject>Transglutaminases - metabolism</subject><subject>Tretinoin - pharmacology</subject><issn>0918-6158</issn><issn>1347-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkM1uEzEUhS0EomlhwwOgkdghTbj-Gf-sUFVBWikSqCoLVpbH9qSOJp5ge1r17XFIaBe-XtzP51gfQh8wLDFh8ku_75dELAnlr9ACUybajuDuNVqAwrLluJNn6DznLQAIIPQtOsNMdBIYWaDft340JUwx34d90_vy6H1s1uHBp-Ymbuf01JjomrtkYt6MczG7EE32zaUt4SGU4HMTYrOaQ_Sm-Rk2-R9-a0p-h94MZsz-_em-QL--f7u7um7XP1Y3V5fr1nLZlRZzZrjCooOhV5Y4OgzSENY7xy1gxZ0njlFsVGcYVcQw7LwC6SljwHvs6AX6dMzdp-nP7HPR22lOsVZqzJiilEsQlfp8pGyack5-0PsUdiY9aQz6YFFXi5oIXS1W-OMpcu533r2gJ20VWB2Bug3WjFMcq4CXYptFH6Zx0gSAaQBSvWsgUA_lhyExCKbwIenrMWmbi9n45yqTSrCjf_7VadTX_zf23iTtI_0LnX-aAA</recordid><startdate>20040201</startdate><enddate>20040201</enddate><creator>Sato, Naoko</creator><creator>Abe, Shinya</creator><creator>Yamada, Takehito</creator><creator>Iwasaki, Koichi</creator><creator>Ohtake, Yosuke</creator><creator>Ohkubo, Yasuhito</creator><general>The Pharmaceutical Society of Japan</general><general>Pharmaceutical Society of Japan</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope></search><sort><creationdate>20040201</creationdate><title>Relationship between Liver Injury and Transglutaminase Activities in Guinea Pigs and Rats</title><author>Sato, Naoko ; Abe, Shinya ; Yamada, Takehito ; Iwasaki, Koichi ; Ohtake, Yosuke ; Ohkubo, Yasuhito</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c685t-164a691750fb9c2d3ff8a24bdd6c0196de2d431a95a4392a41de908e34406b1d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Alanine Transaminase - blood</topic><topic>Animals</topic><topic>carbon tetrachloride (CCl4)</topic><topic>Carbon Tetrachloride Poisoning - enzymology</topic><topic>Chemical and Drug Induced Liver Injury - enzymology</topic><topic>Chemical and Drug Induced Liver Injury - etiology</topic><topic>guinea pig</topic><topic>Guinea Pigs</topic><topic>Male</topic><topic>rat</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>retinoic acid</topic><topic>Species Specificity</topic><topic>transglutaminase (TGase)</topic><topic>Transglutaminases - metabolism</topic><topic>Tretinoin - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sato, Naoko</creatorcontrib><creatorcontrib>Abe, Shinya</creatorcontrib><creatorcontrib>Yamada, Takehito</creatorcontrib><creatorcontrib>Iwasaki, Koichi</creatorcontrib><creatorcontrib>Ohtake, Yosuke</creatorcontrib><creatorcontrib>Ohkubo, Yasuhito</creatorcontrib><creatorcontrib>Tohoku Pharmaceutical University</creatorcontrib><creatorcontrib>Department of Radiopharmacy</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Biological & Pharmaceutical Bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sato, Naoko</au><au>Abe, Shinya</au><au>Yamada, Takehito</au><au>Iwasaki, Koichi</au><au>Ohtake, Yosuke</au><au>Ohkubo, Yasuhito</au><aucorp>Tohoku Pharmaceutical University</aucorp><aucorp>Department of Radiopharmacy</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship between Liver Injury and Transglutaminase Activities in Guinea Pigs and Rats</atitle><jtitle>Biological & Pharmaceutical Bulletin</jtitle><addtitle>Biol Pharm Bull</addtitle><date>2004-02-01</date><risdate>2004</risdate><volume>27</volume><issue>2</issue><spage>236</spage><epage>238</epage><pages>236-238</pages><issn>0918-6158</issn><eissn>1347-5215</eissn><abstract>We investigated the effect of transglutaminase (TGase) on in guinea pigs and rats. Serum alanine aminotransferase (ALT) level increased 1 d after CCl4 treatment of both in guinea pigs and rats since TGaese activity was greatly higher in guinea pigs than rats. However, serum ALT level in guinea pigs was very much lower than that in rats. Liver TGase activities decreased after CCl4 treatment in both guinea pigs and rats. However, TGase activities in the liver from guinea pigs were higher than that from rats. Decreased TGase activities by CCl4 in the liver from guinea pigs and rats were significantly recovered by retinoic acid treatment that was reported to increase TGase. Degree of recovery of serum ALT level by retinoic acid in rats was larger than in guinea pigs. These results suggested that the distinction of the effect of retinoic acid on serum ALT level in CCl4-treated animals was due to the different TGase activity that increased membrane stability.</abstract><cop>Japan</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>14758042</pmid><doi>10.1248/bpb.27.236</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Alanine Transaminase - blood Animals carbon tetrachloride (CCl4) Carbon Tetrachloride Poisoning - enzymology Chemical and Drug Induced Liver Injury - enzymology Chemical and Drug Induced Liver Injury - etiology guinea pig Guinea Pigs Male rat Rats Rats, Wistar retinoic acid Species Specificity transglutaminase (TGase) Transglutaminases - metabolism Tretinoin - pharmacology |
| title | Relationship between Liver Injury and Transglutaminase Activities in Guinea Pigs and Rats |
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