Antiosteoporotic Activity of the Water Extract of Dioscorea spongiosa
After 60 MeOH and water extracts of natural crude drugs were screened for their ability to stimulate osteoblast proliferation, four MeOH extracts (Cynomorium songaricum, Drynaria fortunei, Lycium chinense, Rehmannia glutinosa) and seven water extracts (Cornus officinalis, Dendrobium nobile, Dioscore...
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| Veröffentlicht in: | Biological & Pharmaceutical Bulletin 2004, Vol.27(4), pp.583-586 |
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| container_title | Biological & Pharmaceutical Bulletin |
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| creator | Yin, Jun Tezuka, Yasuhiro Kouda, Kyoji Tran, Quan Le Miyahara, Tatsuro Chen, Yingjie Kadota, Shigetoshi |
| description | After 60 MeOH and water extracts of natural crude drugs were screened for their ability to stimulate osteoblast proliferation, four MeOH extracts (Cynomorium songaricum, Drynaria fortunei, Lycium chinense, Rehmannia glutinosa) and seven water extracts (Cornus officinalis, Dendrobium nobile, Dioscorea spongiosa, Drynaria fortunei, Eucommia ulmoides, Lycium chinensis, Viscum coloratum) showed that potent activities were evaluated for inhibition of osteoclast formation. The results indicated that the water extract of D. spongiosa not only showed the strongest stimulation of osteoblast proliferation but also possessed potent inhibitory activity aganist osteoclast formation, whereas it showed lower cytotoxicity in osteoblast and bone marrow cells. A further in vivo experiment determined the antiosteoporotic activity of this extract, in which it inhibited the decrease in cancellous bone mineral content, cancellous bone mineral density, and cortical bone mineral content of the proximal tibia in ovariectomized rats. |
| doi_str_mv | 10.1248/bpb.27.583 |
| format | Article |
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The results indicated that the water extract of D. spongiosa not only showed the strongest stimulation of osteoblast proliferation but also possessed potent inhibitory activity aganist osteoclast formation, whereas it showed lower cytotoxicity in osteoblast and bone marrow cells. A further in vivo experiment determined the antiosteoporotic activity of this extract, in which it inhibited the decrease in cancellous bone mineral content, cancellous bone mineral density, and cortical bone mineral content of the proximal tibia in ovariectomized rats.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.27.583</identifier><identifier>PMID: 15056872</identifier><language>eng</language><publisher>Japan: The Pharmaceutical Society of Japan</publisher><subject>Animals ; antiosteoporotic activity ; Bone Density - drug effects ; Cell Division - drug effects ; Cell Line ; Dioscorea - chemistry ; Dioscorea spongiosa ; Female ; Mice ; osteoblast ; Osteoblasts - cytology ; Osteoblasts - drug effects ; osteoclast ; Osteoclasts - cytology ; Osteoclasts - drug effects ; Osteoporosis - prevention & control ; Ovariectomy ; peripheral quantitative computed tomography ; Phytotherapy ; Plant Extracts - pharmacology ; Plant Extracts - toxicity ; Rats ; Rats, Wistar ; Water</subject><ispartof>Biological and Pharmaceutical Bulletin, 2004, Vol.27(4), pp.583-586</ispartof><rights>2004 The Pharmaceutical Society of Japan</rights><rights>Copyright Japan Science and Technology Agency 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c685t-6290215f7ab6e847dabfa635c0e4019c30c37a5840cc98364651e17a4d16e943</citedby><cites>FETCH-LOGICAL-c685t-6290215f7ab6e847dabfa635c0e4019c30c37a5840cc98364651e17a4d16e943</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15056872$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yin, Jun</creatorcontrib><creatorcontrib>Tezuka, Yasuhiro</creatorcontrib><creatorcontrib>Kouda, Kyoji</creatorcontrib><creatorcontrib>Tran, Quan Le</creatorcontrib><creatorcontrib>Miyahara, Tatsuro</creatorcontrib><creatorcontrib>Chen, Yingjie</creatorcontrib><creatorcontrib>Kadota, Shigetoshi</creatorcontrib><creatorcontrib>Shenyang Pharmaceutical University</creatorcontrib><creatorcontrib>Faculty of Pharmaceutical Sciences</creatorcontrib><creatorcontrib>Institute of Natural Medicine</creatorcontrib><creatorcontrib>Toyama Medical and Pharmaceutical University</creatorcontrib><title>Antiosteoporotic Activity of the Water Extract of Dioscorea spongiosa</title><title>Biological & Pharmaceutical Bulletin</title><addtitle>Biol Pharm Bull</addtitle><description>After 60 MeOH and water extracts of natural crude drugs were screened for their ability to stimulate osteoblast proliferation, four MeOH extracts (Cynomorium songaricum, Drynaria fortunei, Lycium chinense, Rehmannia glutinosa) and seven water extracts (Cornus officinalis, Dendrobium nobile, Dioscorea spongiosa, Drynaria fortunei, Eucommia ulmoides, Lycium chinensis, Viscum coloratum) showed that potent activities were evaluated for inhibition of osteoclast formation. The results indicated that the water extract of D. spongiosa not only showed the strongest stimulation of osteoblast proliferation but also possessed potent inhibitory activity aganist osteoclast formation, whereas it showed lower cytotoxicity in osteoblast and bone marrow cells. A further in vivo experiment determined the antiosteoporotic activity of this extract, in which it inhibited the decrease in cancellous bone mineral content, cancellous bone mineral density, and cortical bone mineral content of the proximal tibia in ovariectomized rats.</description><subject>Animals</subject><subject>antiosteoporotic activity</subject><subject>Bone Density - drug effects</subject><subject>Cell Division - drug effects</subject><subject>Cell Line</subject><subject>Dioscorea - chemistry</subject><subject>Dioscorea spongiosa</subject><subject>Female</subject><subject>Mice</subject><subject>osteoblast</subject><subject>Osteoblasts - cytology</subject><subject>Osteoblasts - drug effects</subject><subject>osteoclast</subject><subject>Osteoclasts - cytology</subject><subject>Osteoclasts - drug effects</subject><subject>Osteoporosis - prevention & control</subject><subject>Ovariectomy</subject><subject>peripheral quantitative computed tomography</subject><subject>Phytotherapy</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - toxicity</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Water</subject><issn>0918-6158</issn><issn>1347-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkFtLxDAQhYMoul5e_AFS8E3oOrmnT7LoegHBF8HHkGZT7VKbmmRF_70pXfVlhsx8OWc4CJ1imGPC1GU91HMi51zRHTTDlMmSE8x30QwqrEqBuTpAhzGuAUACofvoAHPgQkkyQ8tFn1ofk_ODDz61tljY1H626bvwTZHeXPFikgvF8isFY9M4vMm89cGZIg6-f80vc4z2GtNFd7LtR-j5dvl8fV8-Pt09XC8eSysUT6UgFeTLGmlq4RSTK1M3RlBuwTHAlaVgqTRcMbC2UlQwwbHD0rAVFq5i9AidT7JD8B8bF5Ne-03os6PGjFWUCkl4pi4mygYfY3CNHkL7bsK3xqDHwHQOTBOpc2AZPttKbup3t_pHtwll4G4C8ra1pvN91_bu39hGWbe-85oAMA1A5NhIpSHLj0VgkLwio9LVpLSOyby6PysTcuyd-72KTWX8_buxbyZo19MfXDCSXg</recordid><startdate>20040401</startdate><enddate>20040401</enddate><creator>Yin, Jun</creator><creator>Tezuka, Yasuhiro</creator><creator>Kouda, Kyoji</creator><creator>Tran, Quan Le</creator><creator>Miyahara, Tatsuro</creator><creator>Chen, Yingjie</creator><creator>Kadota, Shigetoshi</creator><general>The Pharmaceutical Society of Japan</general><general>Pharmaceutical Society of Japan</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope></search><sort><creationdate>20040401</creationdate><title>Antiosteoporotic Activity of the Water Extract of Dioscorea spongiosa</title><author>Yin, Jun ; Tezuka, Yasuhiro ; Kouda, Kyoji ; Tran, Quan Le ; Miyahara, Tatsuro ; Chen, Yingjie ; Kadota, Shigetoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c685t-6290215f7ab6e847dabfa635c0e4019c30c37a5840cc98364651e17a4d16e943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>antiosteoporotic activity</topic><topic>Bone Density - drug effects</topic><topic>Cell Division - drug effects</topic><topic>Cell Line</topic><topic>Dioscorea - chemistry</topic><topic>Dioscorea spongiosa</topic><topic>Female</topic><topic>Mice</topic><topic>osteoblast</topic><topic>Osteoblasts - cytology</topic><topic>Osteoblasts - drug effects</topic><topic>osteoclast</topic><topic>Osteoclasts - cytology</topic><topic>Osteoclasts - drug effects</topic><topic>Osteoporosis - prevention & control</topic><topic>Ovariectomy</topic><topic>peripheral quantitative computed tomography</topic><topic>Phytotherapy</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - toxicity</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Water</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yin, Jun</creatorcontrib><creatorcontrib>Tezuka, Yasuhiro</creatorcontrib><creatorcontrib>Kouda, Kyoji</creatorcontrib><creatorcontrib>Tran, Quan Le</creatorcontrib><creatorcontrib>Miyahara, Tatsuro</creatorcontrib><creatorcontrib>Chen, Yingjie</creatorcontrib><creatorcontrib>Kadota, Shigetoshi</creatorcontrib><creatorcontrib>Shenyang Pharmaceutical University</creatorcontrib><creatorcontrib>Faculty of Pharmaceutical Sciences</creatorcontrib><creatorcontrib>Institute of Natural Medicine</creatorcontrib><creatorcontrib>Toyama Medical and Pharmaceutical University</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Biological & Pharmaceutical Bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yin, Jun</au><au>Tezuka, Yasuhiro</au><au>Kouda, Kyoji</au><au>Tran, Quan Le</au><au>Miyahara, Tatsuro</au><au>Chen, Yingjie</au><au>Kadota, Shigetoshi</au><aucorp>Shenyang Pharmaceutical University</aucorp><aucorp>Faculty of Pharmaceutical Sciences</aucorp><aucorp>Institute of Natural Medicine</aucorp><aucorp>Toyama Medical and Pharmaceutical University</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antiosteoporotic Activity of the Water Extract of Dioscorea spongiosa</atitle><jtitle>Biological & Pharmaceutical Bulletin</jtitle><addtitle>Biol Pharm Bull</addtitle><date>2004-04-01</date><risdate>2004</risdate><volume>27</volume><issue>4</issue><spage>583</spage><epage>586</epage><pages>583-586</pages><issn>0918-6158</issn><eissn>1347-5215</eissn><abstract>After 60 MeOH and water extracts of natural crude drugs were screened for their ability to stimulate osteoblast proliferation, four MeOH extracts (Cynomorium songaricum, Drynaria fortunei, Lycium chinense, Rehmannia glutinosa) and seven water extracts (Cornus officinalis, Dendrobium nobile, Dioscorea spongiosa, Drynaria fortunei, Eucommia ulmoides, Lycium chinensis, Viscum coloratum) showed that potent activities were evaluated for inhibition of osteoclast formation. 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| subjects | Animals antiosteoporotic activity Bone Density - drug effects Cell Division - drug effects Cell Line Dioscorea - chemistry Dioscorea spongiosa Female Mice osteoblast Osteoblasts - cytology Osteoblasts - drug effects osteoclast Osteoclasts - cytology Osteoclasts - drug effects Osteoporosis - prevention & control Ovariectomy peripheral quantitative computed tomography Phytotherapy Plant Extracts - pharmacology Plant Extracts - toxicity Rats Rats, Wistar Water |
| title | Antiosteoporotic Activity of the Water Extract of Dioscorea spongiosa |
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