Molecular Mechanism of Cell Death Induced by the Antioxidant tert-Butylhydroxyanisole in Human Monocytic Leukemia U937 Cells

A phenolic antioxidant 3-tert-butyl-4-hydroxyanisole (BHA) is a widely used food additive. BHA had cytotoxicity in human monocytic leukemia U937 cells. BHA at 0.75 mM caused nuclear condensation and fragmentation, structural damage in mitochondria, decrease in mitochondrial transmembrane potential,...

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Veröffentlicht in:	Biological & Pharmaceutical Bulletin 2004, Vol.27(3), pp.295-302
Hauptverfasser:	Okubo, Tomoko, Yokoyama, Yoshiko, Kano, Kazutaka, Kano, Itsu
Format:	Artikel
Sprache:	eng
Schlagworte:	Antioxidants - administration & dosage Antioxidants - pharmacology apoptosis Blotting, Western Butylated Hydroxyanisole - administration & dosage Butylated Hydroxyanisole - pharmacology caspase Caspases - metabolism Cell Death - drug effects Cell Death - physiology Cytochromes c - antagonists & inhibitors DNA ladder Dose-Response Relationship, Drug Electron Transport Complex I - antagonists & inhibitors Electron Transport Complex II - antagonists & inhibitors Electron Transport Complex IV - antagonists & inhibitors Flow Cytometry Glutathione - metabolism Humans Membrane Potentials - drug effects Mitochondria - drug effects Mitochondria - metabolism Mitochondria - physiology mitochondrial transmembrane potential Oxidative Phosphorylation tert-butylhydroxyanisole Time Factors U937 Cells
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