Effects of Low Molecular Weight Chondroitin Sulfate on Type II Collagen-Induced Arthritis in DBA/1J Mice
In order to evaluate the improvement in the treatment of chronic arthritis, we investigated chondroitin sulfate depolymerization product (low molecular weight chondroitin sulfate, LMWCS) and intact chondroitin sulfate (CS) in vitro and in vivo. LMWCS was prepared by a chemical depolymerization proce...
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| Veröffentlicht in: | Biological & Pharmaceutical Bulletin 2004, Vol.27(1), pp.47-51 |
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| creator | Cho, So Yean Sim, Joon-Soo Jeong, Choon Sik Chang, Seung Yeup Choi, Don Woong Toida, Toshihiko Kim, Yeong Shik |
| description | In order to evaluate the improvement in the treatment of chronic arthritis, we investigated chondroitin sulfate depolymerization product (low molecular weight chondroitin sulfate, LMWCS) and intact chondroitin sulfate (CS) in vitro and in vivo. LMWCS was prepared by a chemical depolymerization process induced by hydrogen peroxide in the presence of copper salts. LMWCS (300 mg/kg) and CS (1200 mg/kg) were orally administered to DBA/1J mice once daily for 14 d prior to initial immunization with type II collagen. Their elastase activities and the production of cytokines in sera were examined on type II collagen-induced arthritis in DBA/1J mice. We also compared the paracellular transport of LMWCS and CS across Caco-2 cell monolayers and examined the inhibitory effects on elastase activities. LMWCS inhibited elastase activity slightly, but CS did not show inhibition. Hind paw edema was significantly decreased by LMWCS treatment. Levels of anti-type II collagen antibody and tumor necrosis factor-alpha (TNF-α) in sera were also reduced by LMWCS treatment but not in case of CS, although no significant difference was observed between LMWCS and CS on interleukin-6 (IL-6) induction. The LMWCS preparation showed preventive effects on the type II collagen-induced arthritis in DBA/1J mice and better permeability through Caco-2 cells. |
| doi_str_mv | 10.1248/bpb.27.47 |
| format | Article |
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LMWCS was prepared by a chemical depolymerization process induced by hydrogen peroxide in the presence of copper salts. LMWCS (300 mg/kg) and CS (1200 mg/kg) were orally administered to DBA/1J mice once daily for 14 d prior to initial immunization with type II collagen. Their elastase activities and the production of cytokines in sera were examined on type II collagen-induced arthritis in DBA/1J mice. We also compared the paracellular transport of LMWCS and CS across Caco-2 cell monolayers and examined the inhibitory effects on elastase activities. LMWCS inhibited elastase activity slightly, but CS did not show inhibition. Hind paw edema was significantly decreased by LMWCS treatment. Levels of anti-type II collagen antibody and tumor necrosis factor-alpha (TNF-α) in sera were also reduced by LMWCS treatment but not in case of CS, although no significant difference was observed between LMWCS and CS on interleukin-6 (IL-6) induction. The LMWCS preparation showed preventive effects on the type II collagen-induced arthritis in DBA/1J mice and better permeability through Caco-2 cells.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.27.47</identifier><identifier>PMID: 14709897</identifier><language>eng</language><publisher>Japan: The Pharmaceutical Society of Japan</publisher><subject>Animals ; Antibodies - analysis ; Arthritis - chemically induced ; Arthritis - prevention & control ; Caco-2 cell ; Caco-2 Cells ; Cell Membrane Permeability ; chondroitin sulfate ; Chondroitin Sulfates - analysis ; Chondroitin Sulfates - chemical synthesis ; Chondroitin Sulfates - pharmacology ; Collagen Type II - immunology ; collagen-induced arthritis ; Disaccharides - analysis ; Edema - chemically induced ; Edema - prevention & control ; Humans ; Leukocyte Elastase - antagonists & inhibitors ; Magnetic Resonance Spectroscopy ; Male ; Mice ; Mice, Inbred DBA ; Molecular Weight</subject><ispartof>Biological and Pharmaceutical Bulletin, 2004, Vol.27(1), pp.47-51</ispartof><rights>2004 The Pharmaceutical Society of Japan</rights><rights>Copyright Japan Science and Technology Agency 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c679t-ced19ed11e3777419babba42461e8c45a19797e9a2f37e2188d71c81c109c7ba3</citedby><cites>FETCH-LOGICAL-c679t-ced19ed11e3777419babba42461e8c45a19797e9a2f37e2188d71c81c109c7ba3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,1877,4010,27904,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14709897$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cho, So Yean</creatorcontrib><creatorcontrib>Sim, Joon-Soo</creatorcontrib><creatorcontrib>Jeong, Choon Sik</creatorcontrib><creatorcontrib>Chang, Seung Yeup</creatorcontrib><creatorcontrib>Choi, Don Woong</creatorcontrib><creatorcontrib>Toida, Toshihiko</creatorcontrib><creatorcontrib>Kim, Yeong Shik</creatorcontrib><creatorcontrib>Standardization</creatorcontrib><creatorcontrib>Korea Food and Drug Administration</creatorcontrib><creatorcontrib>Duksung Women's University</creatorcontrib><creatorcontrib>eDepartment of Bioanalytical Chemistry</creatorcontrib><creatorcontrib>aNatural Products Research Institute</creatorcontrib><creatorcontrib>bCollege of Pharmacy</creatorcontrib><creatorcontrib>Graduate School of Pharmaceutical Sciences</creatorcontrib><creatorcontrib>Chiba University</creatorcontrib><creatorcontrib>cDivision of Herbal Medicine</creatorcontrib><creatorcontrib>College of Pharmacy</creatorcontrib><creatorcontrib>dDivision of Drug Evaluation</creatorcontrib><creatorcontrib>Seoul National University</creatorcontrib><title>Effects of Low Molecular Weight Chondroitin Sulfate on Type II Collagen-Induced Arthritis in DBA/1J Mice</title><title>Biological & Pharmaceutical Bulletin</title><addtitle>Biol Pharm Bull</addtitle><description>In order to evaluate the improvement in the treatment of chronic arthritis, we investigated chondroitin sulfate depolymerization product (low molecular weight chondroitin sulfate, LMWCS) and intact chondroitin sulfate (CS) in vitro and in vivo. LMWCS was prepared by a chemical depolymerization process induced by hydrogen peroxide in the presence of copper salts. LMWCS (300 mg/kg) and CS (1200 mg/kg) were orally administered to DBA/1J mice once daily for 14 d prior to initial immunization with type II collagen. Their elastase activities and the production of cytokines in sera were examined on type II collagen-induced arthritis in DBA/1J mice. We also compared the paracellular transport of LMWCS and CS across Caco-2 cell monolayers and examined the inhibitory effects on elastase activities. LMWCS inhibited elastase activity slightly, but CS did not show inhibition. Hind paw edema was significantly decreased by LMWCS treatment. Levels of anti-type II collagen antibody and tumor necrosis factor-alpha (TNF-α) in sera were also reduced by LMWCS treatment but not in case of CS, although no significant difference was observed between LMWCS and CS on interleukin-6 (IL-6) induction. The LMWCS preparation showed preventive effects on the type II collagen-induced arthritis in DBA/1J mice and better permeability through Caco-2 cells.</description><subject>Animals</subject><subject>Antibodies - analysis</subject><subject>Arthritis - chemically induced</subject><subject>Arthritis - prevention & control</subject><subject>Caco-2 cell</subject><subject>Caco-2 Cells</subject><subject>Cell Membrane Permeability</subject><subject>chondroitin sulfate</subject><subject>Chondroitin Sulfates - analysis</subject><subject>Chondroitin Sulfates - chemical synthesis</subject><subject>Chondroitin Sulfates - pharmacology</subject><subject>Collagen Type II - immunology</subject><subject>collagen-induced arthritis</subject><subject>Disaccharides - analysis</subject><subject>Edema - chemically induced</subject><subject>Edema - prevention & control</subject><subject>Humans</subject><subject>Leukocyte Elastase - antagonists & inhibitors</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred DBA</subject><subject>Molecular Weight</subject><issn>0918-6158</issn><issn>1347-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEFv1DAQhS0EotvCgT-ALHHqIVuP4-zYF6RlKWXRVhxo1aPlOE6TlRsvdqKq_x5X2dLDzBzmm_dGj5BPwJbAhbyoD_WS41LgG7KAUmBRcajekgVTIIsVVPKEnKa0Z4wh4-V7cgICmZIKF6S7bFtnx0RDS3fhkV4H7-zkTaR3rr_vRrrpwtDE0I_9QP9MvjWjo2GgN08HR7dbugnem3s3FNuhmaxr6DqOXcx0ovng-7f1Bfyi1711H8i71vjkPh7nGbn9cXmz-Vnsfl9tN-tdYVeoxiJLgMoFrkREAao2dW0EFytw0orKgEKFThnelug4SNkgWAkWmLJYm_KMfJl1DzH8nVwa9T5McciWGoRQZbkCLDN1PlM2hpSia_Uh9g8mPmlg-jlTnTPVHLXAzH4-Kk71g2teyWOIGbiagbztrfFh8P3gXn1twroPPmjOmNCMcWSQh8wlMLcKgCHnSmalr7PSPo051f9WJo699e7lKZhbPn5Z2M5E7YbyH8FonSg</recordid><startdate>2004</startdate><enddate>2004</enddate><creator>Cho, So Yean</creator><creator>Sim, Joon-Soo</creator><creator>Jeong, Choon Sik</creator><creator>Chang, Seung Yeup</creator><creator>Choi, Don Woong</creator><creator>Toida, Toshihiko</creator><creator>Kim, Yeong Shik</creator><general>The Pharmaceutical Society of Japan</general><general>Pharmaceutical Society of Japan</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope></search><sort><creationdate>2004</creationdate><title>Effects of Low Molecular Weight Chondroitin Sulfate on Type II Collagen-Induced Arthritis in DBA/1J Mice</title><author>Cho, So Yean ; 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LMWCS was prepared by a chemical depolymerization process induced by hydrogen peroxide in the presence of copper salts. LMWCS (300 mg/kg) and CS (1200 mg/kg) were orally administered to DBA/1J mice once daily for 14 d prior to initial immunization with type II collagen. Their elastase activities and the production of cytokines in sera were examined on type II collagen-induced arthritis in DBA/1J mice. We also compared the paracellular transport of LMWCS and CS across Caco-2 cell monolayers and examined the inhibitory effects on elastase activities. LMWCS inhibited elastase activity slightly, but CS did not show inhibition. Hind paw edema was significantly decreased by LMWCS treatment. Levels of anti-type II collagen antibody and tumor necrosis factor-alpha (TNF-α) in sera were also reduced by LMWCS treatment but not in case of CS, although no significant difference was observed between LMWCS and CS on interleukin-6 (IL-6) induction. The LMWCS preparation showed preventive effects on the type II collagen-induced arthritis in DBA/1J mice and better permeability through Caco-2 cells.</abstract><cop>Japan</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>14709897</pmid><doi>10.1248/bpb.27.47</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Antibodies - analysis Arthritis - chemically induced Arthritis - prevention & control Caco-2 cell Caco-2 Cells Cell Membrane Permeability chondroitin sulfate Chondroitin Sulfates - analysis Chondroitin Sulfates - chemical synthesis Chondroitin Sulfates - pharmacology Collagen Type II - immunology collagen-induced arthritis Disaccharides - analysis Edema - chemically induced Edema - prevention & control Humans Leukocyte Elastase - antagonists & inhibitors Magnetic Resonance Spectroscopy Male Mice Mice, Inbred DBA Molecular Weight |
| title | Effects of Low Molecular Weight Chondroitin Sulfate on Type II Collagen-Induced Arthritis in DBA/1J Mice |
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