Protective Effect of Aqueous Extract of Ginseng radix against 1-Methyl-4-phenylpyridinium-Induced Apoptosis in PC12 Cells
Ginseng radix, the root of Panax ginseng C. A. MEYER (Araliaceae), is one of the best-known Oriental medicinal herbs with numerous therapeutic applications. To investigate whether Ginseng radix possesses a protective effect against 1-methyl-4-phenylpyridine (MPP+)-induced cytotoxicity in neuronal ce...
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| Veröffentlicht in: | Biological & Pharmaceutical Bulletin 2003, Vol.26(12), pp.1668-1673 |
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| creator | Kim, Ee-Hwa Jang, Mi-Hyeon Shin, Min-Chul Shin, Mal-Soon Kim, Chang-Ju |
| description | Ginseng radix, the root of Panax ginseng C. A. MEYER (Araliaceae), is one of the best-known Oriental medicinal herbs with numerous therapeutic applications. To investigate whether Ginseng radix possesses a protective effect against 1-methyl-4-phenylpyridine (MPP+)-induced cytotoxicity in neuronal cells, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, flow cytometry, DNA fragmentation assay, reverse transcription-polymerase chain reaction (RT-PCR), Western blotting, and caspase-3 enzyme assay were performed on PC12 neuronal cells. Cells treated with MPP+ exhibited various apoptotic features, while cell pretreated with Ginseng radix prior to MPP+ exposure showed a decrease in the occurrence of apoptotic features. These results suggest that Ginseng radix may exert a protective effect against MPP+-induced apoptosis in PC12 cells. |
| doi_str_mv | 10.1248/bpb.26.1668 |
| format | Article |
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A. MEYER (Araliaceae), is one of the best-known Oriental medicinal herbs with numerous therapeutic applications. To investigate whether Ginseng radix possesses a protective effect against 1-methyl-4-phenylpyridine (MPP+)-induced cytotoxicity in neuronal cells, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, flow cytometry, DNA fragmentation assay, reverse transcription-polymerase chain reaction (RT-PCR), Western blotting, and caspase-3 enzyme assay were performed on PC12 neuronal cells. Cells treated with MPP+ exhibited various apoptotic features, while cell pretreated with Ginseng radix prior to MPP+ exposure showed a decrease in the occurrence of apoptotic features. These results suggest that Ginseng radix may exert a protective effect against MPP+-induced apoptosis in PC12 cells.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.26.1668</identifier><identifier>PMID: 14646168</identifier><language>eng</language><publisher>Tokyo: The Pharmaceutical Society of Japan</publisher><subject>1-methyl-4-phenylpyridine (MPP+) ; 1-Methyl-4-phenylpyridinium - adverse effects ; 1-Methyl-4-phenylpyridinium - antagonists & inhibitors ; 1-Methyl-4-phenylpyridinium - pharmacokinetics ; Animals ; apoptosis ; Apoptosis - drug effects ; bcl-2-Associated X Protein ; Biological and medical sciences ; Blotting, Western ; Caspase 3 ; Caspase Inhibitors ; Caspases - drug effects ; Caspases - metabolism ; Cell Cycle - drug effects ; Cell Shape - drug effects ; Cell Survival - drug effects ; DNA Fragmentation - drug effects ; Dose-Response Relationship, Drug ; Drugs, Chinese Herbal - pharmacology ; General pharmacology ; Genes, p53 - genetics ; Ginseng radix ; Medical sciences ; Neurons - drug effects ; Neurons - metabolism ; Panax - chemistry ; Parkinson's disease ; PC12 Cells ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Plant Extracts - chemistry ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; Plant Roots - chemistry ; Plants, Medicinal - chemistry ; Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors ; Proto-Oncogene Proteins c-bcl-2 - genetics ; Proto-Oncogene Proteins c-bcl-2 - metabolism ; Rats ; Tetrazolium Salts - metabolism ; Thiazoles - metabolism ; Time Factors ; Tumor Suppressor Protein p53 - antagonists & inhibitors ; Tumor Suppressor Protein p53 - genetics ; Tumor Suppressor Protein p53 - metabolism ; Water</subject><ispartof>Biological and Pharmaceutical Bulletin, 2003, Vol.26(12), pp.1668-1673</ispartof><rights>2003 The Pharmaceutical Society of Japan</rights><rights>2004 INIST-CNRS</rights><rights>Copyright Japan Science and Technology Agency 2003</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c719t-e3d4d2a106aab1a50f152c303cddc3011472dfda665234dcab6390c5289435383</citedby><cites>FETCH-LOGICAL-c719t-e3d4d2a106aab1a50f152c303cddc3011472dfda665234dcab6390c5289435383</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15407757$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14646168$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Ee-Hwa</creatorcontrib><creatorcontrib>Jang, Mi-Hyeon</creatorcontrib><creatorcontrib>Shin, Min-Chul</creatorcontrib><creatorcontrib>Shin, Mal-Soon</creatorcontrib><creatorcontrib>Kim, Chang-Ju</creatorcontrib><creatorcontrib>College of Medicine</creatorcontrib><creatorcontrib>College of Oriental Medicine</creatorcontrib><creatorcontrib>Kyung Hee University</creatorcontrib><creatorcontrib>aDepartment of Meridian & Acupoint</creatorcontrib><creatorcontrib>bDepartment of Physiology</creatorcontrib><creatorcontrib>Semyung University</creatorcontrib><title>Protective Effect of Aqueous Extract of Ginseng radix against 1-Methyl-4-phenylpyridinium-Induced Apoptosis in PC12 Cells</title><title>Biological & Pharmaceutical Bulletin</title><addtitle>Biol Pharm Bull</addtitle><description>Ginseng radix, the root of Panax ginseng C. A. MEYER (Araliaceae), is one of the best-known Oriental medicinal herbs with numerous therapeutic applications. To investigate whether Ginseng radix possesses a protective effect against 1-methyl-4-phenylpyridine (MPP+)-induced cytotoxicity in neuronal cells, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, flow cytometry, DNA fragmentation assay, reverse transcription-polymerase chain reaction (RT-PCR), Western blotting, and caspase-3 enzyme assay were performed on PC12 neuronal cells. Cells treated with MPP+ exhibited various apoptotic features, while cell pretreated with Ginseng radix prior to MPP+ exposure showed a decrease in the occurrence of apoptotic features. These results suggest that Ginseng radix may exert a protective effect against MPP+-induced apoptosis in PC12 cells.</description><subject>1-methyl-4-phenylpyridine (MPP+)</subject><subject>1-Methyl-4-phenylpyridinium - adverse effects</subject><subject>1-Methyl-4-phenylpyridinium - antagonists & inhibitors</subject><subject>1-Methyl-4-phenylpyridinium - pharmacokinetics</subject><subject>Animals</subject><subject>apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>bcl-2-Associated X Protein</subject><subject>Biological and medical sciences</subject><subject>Blotting, Western</subject><subject>Caspase 3</subject><subject>Caspase Inhibitors</subject><subject>Caspases - drug effects</subject><subject>Caspases - metabolism</subject><subject>Cell Cycle - drug effects</subject><subject>Cell Shape - drug effects</subject><subject>Cell Survival - drug effects</subject><subject>DNA Fragmentation - drug effects</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drugs, Chinese Herbal - pharmacology</subject><subject>General pharmacology</subject><subject>Genes, p53 - genetics</subject><subject>Ginseng radix</subject><subject>Medical sciences</subject><subject>Neurons - drug effects</subject><subject>Neurons - metabolism</subject><subject>Panax - chemistry</subject><subject>Parkinson's disease</subject><subject>PC12 Cells</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>Plant Roots - chemistry</subject><subject>Plants, Medicinal - chemistry</subject><subject>Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors</subject><subject>Proto-Oncogene Proteins c-bcl-2 - genetics</subject><subject>Proto-Oncogene Proteins c-bcl-2 - metabolism</subject><subject>Rats</subject><subject>Tetrazolium Salts - metabolism</subject><subject>Thiazoles - metabolism</subject><subject>Time Factors</subject><subject>Tumor Suppressor Protein p53 - antagonists & inhibitors</subject><subject>Tumor Suppressor Protein p53 - genetics</subject><subject>Tumor Suppressor Protein p53 - metabolism</subject><subject>Water</subject><issn>0918-6158</issn><issn>1347-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkc2P0zAQxSMEYsvCiTuyhDihFI_tOMmxVKWstIg9wNlybKd1ldrBTtDmv8fdhO1lxh8_vXl-zrL3gNdAWPWl6Zs14WvgvHqRrYCyMi8IFC-zFa6hyjkU1U32JsYTxrjEhL7OboBxxoFXq2x6CH4warB_Ddq1bVoh36LNn9H4MaLd4xDkfLS3Lhp3QEFq-4jkQab9gCD_YYbj1OUs74_GTV0_Bauts-M5v3N6VEajTe_7wUcbkXXoYQsEbU3XxbfZq1Z20bxb-m32-9vu1_Z7fv9zf7fd3OeqhHrIDdVMEwmYS9mALHALBVEUU6V1agCsJLrVkvOCUKaVbDitsSpIVTNa0IreZh9n3T749Kw4iJMfg0sjBTBWU1JDiRP1eaZU8DEG04o-2LMMkwAsLjGLFLMgXFxiTvSHRXNszkZf2SXXBHxaABmV7NognbLxyhUMl2VRJm4_c0nFJtC7zjpzdahi2VjfeUEwpgJjwoGkNttIpaRw-dMnpa-z0ikO8mCeR8kwWNWZZ_tkqU8C_y_VUQZhHP0H74Gyig</recordid><startdate>20031201</startdate><enddate>20031201</enddate><creator>Kim, Ee-Hwa</creator><creator>Jang, Mi-Hyeon</creator><creator>Shin, Min-Chul</creator><creator>Shin, Mal-Soon</creator><creator>Kim, Chang-Ju</creator><general>The Pharmaceutical Society of Japan</general><general>Pharmaceutical Society of Japan</general><general>Maruzen</general><general>Japan Science and Technology Agency</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope></search><sort><creationdate>20031201</creationdate><title>Protective Effect of Aqueous Extract of Ginseng radix against 1-Methyl-4-phenylpyridinium-Induced Apoptosis in PC12 Cells</title><author>Kim, Ee-Hwa ; Jang, Mi-Hyeon ; Shin, Min-Chul ; Shin, Mal-Soon ; Kim, Chang-Ju</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c719t-e3d4d2a106aab1a50f152c303cddc3011472dfda665234dcab6390c5289435383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>1-methyl-4-phenylpyridine (MPP+)</topic><topic>1-Methyl-4-phenylpyridinium - adverse effects</topic><topic>1-Methyl-4-phenylpyridinium - antagonists & inhibitors</topic><topic>1-Methyl-4-phenylpyridinium - pharmacokinetics</topic><topic>Animals</topic><topic>apoptosis</topic><topic>Apoptosis - drug effects</topic><topic>bcl-2-Associated X Protein</topic><topic>Biological and medical sciences</topic><topic>Blotting, Western</topic><topic>Caspase 3</topic><topic>Caspase Inhibitors</topic><topic>Caspases - drug effects</topic><topic>Caspases - metabolism</topic><topic>Cell Cycle - drug effects</topic><topic>Cell Shape - drug effects</topic><topic>Cell Survival - drug effects</topic><topic>DNA Fragmentation - drug effects</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drugs, Chinese Herbal - pharmacology</topic><topic>General pharmacology</topic><topic>Genes, p53 - genetics</topic><topic>Ginseng radix</topic><topic>Medical sciences</topic><topic>Neurons - drug effects</topic><topic>Neurons - metabolism</topic><topic>Panax - chemistry</topic><topic>Parkinson's disease</topic><topic>PC12 Cells</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - therapeutic use</topic><topic>Plant Roots - chemistry</topic><topic>Plants, Medicinal - chemistry</topic><topic>Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors</topic><topic>Proto-Oncogene Proteins c-bcl-2 - genetics</topic><topic>Proto-Oncogene Proteins c-bcl-2 - metabolism</topic><topic>Rats</topic><topic>Tetrazolium Salts - metabolism</topic><topic>Thiazoles - metabolism</topic><topic>Time Factors</topic><topic>Tumor Suppressor Protein p53 - antagonists & inhibitors</topic><topic>Tumor Suppressor Protein p53 - genetics</topic><topic>Tumor Suppressor Protein p53 - metabolism</topic><topic>Water</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Ee-Hwa</creatorcontrib><creatorcontrib>Jang, Mi-Hyeon</creatorcontrib><creatorcontrib>Shin, Min-Chul</creatorcontrib><creatorcontrib>Shin, Mal-Soon</creatorcontrib><creatorcontrib>Kim, Chang-Ju</creatorcontrib><creatorcontrib>College of Medicine</creatorcontrib><creatorcontrib>College of Oriental Medicine</creatorcontrib><creatorcontrib>Kyung Hee University</creatorcontrib><creatorcontrib>aDepartment of Meridian & Acupoint</creatorcontrib><creatorcontrib>bDepartment of Physiology</creatorcontrib><creatorcontrib>Semyung University</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Biological & Pharmaceutical Bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Ee-Hwa</au><au>Jang, Mi-Hyeon</au><au>Shin, Min-Chul</au><au>Shin, Mal-Soon</au><au>Kim, Chang-Ju</au><aucorp>College of Medicine</aucorp><aucorp>College of Oriental Medicine</aucorp><aucorp>Kyung Hee University</aucorp><aucorp>aDepartment of Meridian & Acupoint</aucorp><aucorp>bDepartment of Physiology</aucorp><aucorp>Semyung University</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protective Effect of Aqueous Extract of Ginseng radix against 1-Methyl-4-phenylpyridinium-Induced Apoptosis in PC12 Cells</atitle><jtitle>Biological & Pharmaceutical Bulletin</jtitle><addtitle>Biol Pharm Bull</addtitle><date>2003-12-01</date><risdate>2003</risdate><volume>26</volume><issue>12</issue><spage>1668</spage><epage>1673</epage><pages>1668-1673</pages><issn>0918-6158</issn><eissn>1347-5215</eissn><abstract>Ginseng radix, the root of Panax ginseng C. A. MEYER (Araliaceae), is one of the best-known Oriental medicinal herbs with numerous therapeutic applications. To investigate whether Ginseng radix possesses a protective effect against 1-methyl-4-phenylpyridine (MPP+)-induced cytotoxicity in neuronal cells, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, flow cytometry, DNA fragmentation assay, reverse transcription-polymerase chain reaction (RT-PCR), Western blotting, and caspase-3 enzyme assay were performed on PC12 neuronal cells. Cells treated with MPP+ exhibited various apoptotic features, while cell pretreated with Ginseng radix prior to MPP+ exposure showed a decrease in the occurrence of apoptotic features. These results suggest that Ginseng radix may exert a protective effect against MPP+-induced apoptosis in PC12 cells.</abstract><cop>Tokyo</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>14646168</pmid><doi>10.1248/bpb.26.1668</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 1-methyl-4-phenylpyridine (MPP+) 1-Methyl-4-phenylpyridinium - adverse effects 1-Methyl-4-phenylpyridinium - antagonists & inhibitors 1-Methyl-4-phenylpyridinium - pharmacokinetics Animals apoptosis Apoptosis - drug effects bcl-2-Associated X Protein Biological and medical sciences Blotting, Western Caspase 3 Caspase Inhibitors Caspases - drug effects Caspases - metabolism Cell Cycle - drug effects Cell Shape - drug effects Cell Survival - drug effects DNA Fragmentation - drug effects Dose-Response Relationship, Drug Drugs, Chinese Herbal - pharmacology General pharmacology Genes, p53 - genetics Ginseng radix Medical sciences Neurons - drug effects Neurons - metabolism Panax - chemistry Parkinson's disease PC12 Cells Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Extracts - chemistry Plant Extracts - pharmacology Plant Extracts - therapeutic use Plant Roots - chemistry Plants, Medicinal - chemistry Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-bcl-2 - metabolism Rats Tetrazolium Salts - metabolism Thiazoles - metabolism Time Factors Tumor Suppressor Protein p53 - antagonists & inhibitors Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Water |
| title | Protective Effect of Aqueous Extract of Ginseng radix against 1-Methyl-4-phenylpyridinium-Induced Apoptosis in PC12 Cells |
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