Diethyldithiocarbamate-Induced Cytotoxicity and Apoptosis in Leukemia Cell Lines

Diethyldithiocarbamate (DDTC) has been shown to induce cytotoxicity in several different systems. We examined whether the DDTC-induced cytotoxicity was via apoptosis, or in relation to intracellular glutathione (GSH) in various murine and human leukemia cell lines. The cells most sensitive to DDTC-i...

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Veröffentlicht in:	Biological & Pharmaceutical Bulletin 2003, Vol.26(7), pp.964-968
Hauptverfasser:	Kanno, Syu-ichi, Matsukawa, Emi, Miura, Ai, Shouji, Ai, Asou, Keiko, Ishikawa, Masaaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents apoptosis Apoptosis - drug effects Apoptosis - physiology Biological and medical sciences Cell Line, Tumor - drug effects Cell Line, Tumor - metabolism Cell Survival - drug effects Cell Survival - physiology cytotoxicity diethyldithiocarbamate Ditiocarb - toxicity General aspects glutathione HL-60 Cells Humans Jurkat Cells Leukemia - metabolism leukemia cell Medical sciences Pharmacology. Drug treatments U937 Cells
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