Effect of Chondroitin Sulfate on the Biodegradation and Drug Release of Chitosan Gel Beads in Subcutaneous Air Pouches of Mice
Chitosan (CS) gel beads were prepared in 10% amino acid solution (pH 9) and modified by forming an electrostatic complex between the amino group of CS and the carboxyl group of chondroitin sulfate (Cho). Modification of the CS gel matrix by Cho inhibited the in vitro release of prednisolone (PS) fro...
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| Veröffentlicht in: | Biological & pharmaceutical bulletin 2002, Vol.25(2), pp.268-271 |
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| creator | Kofuji, Kyoko Ito, Tomohiro Murata, Yoshifumi Kawashima, Susumu |
| description | Chitosan (CS) gel beads were prepared in 10% amino acid solution (pH 9) and modified by forming an electrostatic complex between the amino group of CS and the carboxyl group of chondroitin sulfate (Cho). Modification of the CS gel matrix by Cho inhibited the in vitro release of prednisolone (PS) from the gel beads. CS gel beads modified by Cho (CS-Cho) were implanted into air pouches (AP) prepared subcutaneously on the dorsal surfaces of mice. No inflammatory response was observed. The in vivo release of PS from CS-Cho gel beads and their biodegradation in the AP was slower than beads without Cho treatment. After 28 days of implantation, CS-Cho gel beads (deacetylation of CS: 90%) were still detectable, although they had become softer and smaller. Modification of the CS gel matrix by Cho controls the biodegradation of the beads and the release of the drug. This effect makes these beads a promising biocompatible and biodegradable vehicle for sustained drug delivery. |
| doi_str_mv | 10.1248/bpb.25.268 |
| format | Article |
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Modification of the CS gel matrix by Cho inhibited the in vitro release of prednisolone (PS) from the gel beads. CS gel beads modified by Cho (CS-Cho) were implanted into air pouches (AP) prepared subcutaneously on the dorsal surfaces of mice. No inflammatory response was observed. The in vivo release of PS from CS-Cho gel beads and their biodegradation in the AP was slower than beads without Cho treatment. After 28 days of implantation, CS-Cho gel beads (deacetylation of CS: 90%) were still detectable, although they had become softer and smaller. Modification of the CS gel matrix by Cho controls the biodegradation of the beads and the release of the drug. This effect makes these beads a promising biocompatible and biodegradable vehicle for sustained drug delivery.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.25.268</identifier><identifier>PMID: 11853181</identifier><language>eng</language><publisher>Tokyo: The Pharmaceutical Society of Japan</publisher><subject>air pouch ; Analysis ; Animals ; biodegradation ; Biodegradation, Environmental ; Biological and medical sciences ; Bones, joints and connective tissue. Antiinflammatory agents ; Chitin - administration & dosage ; Chitin - analogs & derivatives ; Chitosan ; chondroitin sulfate ; Chondroitin Sulfates - pharmacology ; Drug Delivery Systems ; gel ; Gels ; General pharmacology ; Male ; Medical sciences ; Mice ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; Prednisolone - administration & dosage ; Prednisolone - chemistry ; Prednisolone - pharmacokinetics ; Solubility ; sustained release</subject><ispartof>Biological and Pharmaceutical Bulletin, 2002, Vol.25(2), pp.268-271</ispartof><rights>2002 The Pharmaceutical Society of Japan</rights><rights>2002 INIST-CNRS</rights><rights>Copyright Japan Science and Technology Agency 2002</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c723t-6404dcc4d080d2aa341722dc47d290d9e9432b4f662042f76ec8b0c2ac174f0b3</citedby><cites>FETCH-LOGICAL-c723t-6404dcc4d080d2aa341722dc47d290d9e9432b4f662042f76ec8b0c2ac174f0b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1876,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13531733$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13619138$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11853181$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kofuji, Kyoko</creatorcontrib><creatorcontrib>Ito, Tomohiro</creatorcontrib><creatorcontrib>Murata, Yoshifumi</creatorcontrib><creatorcontrib>Kawashima, Susumu</creatorcontrib><title>Effect of Chondroitin Sulfate on the Biodegradation and Drug Release of Chitosan Gel Beads in Subcutaneous Air Pouches of Mice</title><title>Biological & pharmaceutical bulletin</title><addtitle>Biol Pharm Bull</addtitle><description>Chitosan (CS) gel beads were prepared in 10% amino acid solution (pH 9) and modified by forming an electrostatic complex between the amino group of CS and the carboxyl group of chondroitin sulfate (Cho). Modification of the CS gel matrix by Cho inhibited the in vitro release of prednisolone (PS) from the gel beads. CS gel beads modified by Cho (CS-Cho) were implanted into air pouches (AP) prepared subcutaneously on the dorsal surfaces of mice. No inflammatory response was observed. The in vivo release of PS from CS-Cho gel beads and their biodegradation in the AP was slower than beads without Cho treatment. After 28 days of implantation, CS-Cho gel beads (deacetylation of CS: 90%) were still detectable, although they had become softer and smaller. Modification of the CS gel matrix by Cho controls the biodegradation of the beads and the release of the drug. This effect makes these beads a promising biocompatible and biodegradable vehicle for sustained drug delivery.</description><subject>air pouch</subject><subject>Analysis</subject><subject>Animals</subject><subject>biodegradation</subject><subject>Biodegradation, Environmental</subject><subject>Biological and medical sciences</subject><subject>Bones, joints and connective tissue. Antiinflammatory agents</subject><subject>Chitin - administration & dosage</subject><subject>Chitin - analogs & derivatives</subject><subject>Chitosan</subject><subject>chondroitin sulfate</subject><subject>Chondroitin Sulfates - pharmacology</subject><subject>Drug Delivery Systems</subject><subject>gel</subject><subject>Gels</subject><subject>General pharmacology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Prednisolone - administration & dosage</subject><subject>Prednisolone - chemistry</subject><subject>Prednisolone - pharmacokinetics</subject><subject>Solubility</subject><subject>sustained release</subject><issn>0918-6158</issn><issn>1347-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0Mtu1DAUBmALgehQ2PAAyBJig5TBtyTOCrVDKUhFIC7r6MQ-nvEotae2s2DDs5My0XTJxpbs7_y2fkJecrbmQul3w2FYi3otGv2IrLhUbVULXj8mK9ZxXTW81mfkWc57xljLhHxKzjjXteSar8ifK-fQFBod3exisCn64gP9MY0OCtIYaNkhvfTR4jaBheLnIwiWfkjTln7HESHjcdqXmCHQaxzpJYLN9F_OYKYCAeOU6YVP9FuczA7z_cQXb_A5eeJgzPhi2c_Jr49XPzefqpuv1583FzeVaYUsVaOYssYoyzSzAkAq3gphjWqt6JjtsFNSDMo1jWBKuLZBowdmBBjeKscGeU5eH3MPKd5NmEu_j1MK85M9V6rjXdfyelZvj8qkmHNC1x-Sv4X0u-esv6-6n6vuRd3PVc_41RI5DbdoH-jS7QzeLACygdElCMbnBycb3nGp_-_muFbK2b0_un0usMUTgFS8GfH0t2Vp9OnG7CD1GORfAC-pYA</recordid><startdate>20020201</startdate><enddate>20020201</enddate><creator>Kofuji, Kyoko</creator><creator>Ito, Tomohiro</creator><creator>Murata, Yoshifumi</creator><creator>Kawashima, Susumu</creator><general>The Pharmaceutical Society of Japan</general><general>Maruzen</general><general>Japan Science and Technology Agency</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope></search><sort><creationdate>20020201</creationdate><title>Effect of Chondroitin Sulfate on the Biodegradation and Drug Release of Chitosan Gel Beads in Subcutaneous Air Pouches of Mice</title><author>Kofuji, Kyoko ; Ito, Tomohiro ; Murata, Yoshifumi ; Kawashima, Susumu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c723t-6404dcc4d080d2aa341722dc47d290d9e9432b4f662042f76ec8b0c2ac174f0b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>air pouch</topic><topic>Analysis</topic><topic>Animals</topic><topic>biodegradation</topic><topic>Biodegradation, Environmental</topic><topic>Biological and medical sciences</topic><topic>Bones, joints and connective tissue. Antiinflammatory agents</topic><topic>Chitin - administration & dosage</topic><topic>Chitin - analogs & derivatives</topic><topic>Chitosan</topic><topic>chondroitin sulfate</topic><topic>Chondroitin Sulfates - pharmacology</topic><topic>Drug Delivery Systems</topic><topic>gel</topic><topic>Gels</topic><topic>General pharmacology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Prednisolone - administration & dosage</topic><topic>Prednisolone - chemistry</topic><topic>Prednisolone - pharmacokinetics</topic><topic>Solubility</topic><topic>sustained release</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kofuji, Kyoko</creatorcontrib><creatorcontrib>Ito, Tomohiro</creatorcontrib><creatorcontrib>Murata, Yoshifumi</creatorcontrib><creatorcontrib>Kawashima, Susumu</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Biological & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kofuji, Kyoko</au><au>Ito, Tomohiro</au><au>Murata, Yoshifumi</au><au>Kawashima, Susumu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Chondroitin Sulfate on the Biodegradation and Drug Release of Chitosan Gel Beads in Subcutaneous Air Pouches of Mice</atitle><jtitle>Biological & pharmaceutical bulletin</jtitle><addtitle>Biol Pharm Bull</addtitle><date>2002-02-01</date><risdate>2002</risdate><volume>25</volume><issue>2</issue><spage>268</spage><epage>271</epage><pages>268-271</pages><issn>0918-6158</issn><eissn>1347-5215</eissn><abstract>Chitosan (CS) gel beads were prepared in 10% amino acid solution (pH 9) and modified by forming an electrostatic complex between the amino group of CS and the carboxyl group of chondroitin sulfate (Cho). Modification of the CS gel matrix by Cho inhibited the in vitro release of prednisolone (PS) from the gel beads. CS gel beads modified by Cho (CS-Cho) were implanted into air pouches (AP) prepared subcutaneously on the dorsal surfaces of mice. No inflammatory response was observed. The in vivo release of PS from CS-Cho gel beads and their biodegradation in the AP was slower than beads without Cho treatment. After 28 days of implantation, CS-Cho gel beads (deacetylation of CS: 90%) were still detectable, although they had become softer and smaller. Modification of the CS gel matrix by Cho controls the biodegradation of the beads and the release of the drug. This effect makes these beads a promising biocompatible and biodegradable vehicle for sustained drug delivery.</abstract><cop>Tokyo</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>11853181</pmid><doi>10.1248/bpb.25.268</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | air pouch Analysis Animals biodegradation Biodegradation, Environmental Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Chitin - administration & dosage Chitin - analogs & derivatives Chitosan chondroitin sulfate Chondroitin Sulfates - pharmacology Drug Delivery Systems gel Gels General pharmacology Male Medical sciences Mice Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Prednisolone - administration & dosage Prednisolone - chemistry Prednisolone - pharmacokinetics Solubility sustained release |
| title | Effect of Chondroitin Sulfate on the Biodegradation and Drug Release of Chitosan Gel Beads in Subcutaneous Air Pouches of Mice |
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