In Vitro Antiinflammatory Activity of Kalopanaxsaponin A Isolated from Kalopanax pictus in Murine Macrophage RAW 264.7 Cells
In the present study, effects of various hederagenin monodesmosides isolated from the stem bark of Kalopanax pictus NAKAI, such as hederagenin, δ-hederin, kalopanaxsaponin A, kalopanaxsaponin I, and sapindoside C, have been evaluated on lipopolysaccharide (LPS)-induced nitric oxide (NO), prostagland...
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| Veröffentlicht in: | Biological & pharmaceutical bulletin 2002, Vol.25(4), pp.472-476 |
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| creator | Kim, Young-Kwan Kim, Ryung-Gue Park, So-Jung Ha, Joo-Hun Choi, Jong-Won Park, Hee-Juhn Lee, Kyung-Tae |
| description | In the present study, effects of various hederagenin monodesmosides isolated from the stem bark of Kalopanax pictus NAKAI, such as hederagenin, δ-hederin, kalopanaxsaponin A, kalopanaxsaponin I, and sapindoside C, have been evaluated on lipopolysaccharide (LPS)-induced nitric oxide (NO), prostaglandin E2 (PGE2) and tumor necrosis factor-α (TNF-α) release by the macrophage cell line RAW 264.7. Among the tested monodesmosides, kalopanxsaponin A was the most potent inhibitor of NO production, and it also significantly decreased PGE2 and TNF-α release. Consistent with these observations, the expression level of inducible NO synthase (iNOS) and cyclooxygenase (COX)-2 enzyme was inhibited by kalopanxsaponin A in a concentration-dependent manner. Thus, this study suggests that kalopanaxsaponin A-mediated inhibition of iNOS, COX-2 expression, and TNF-α release may be one of the mechanisms responsible for the anti-inflammatory effects of the stem bark of Kalopanax pictus NAKAI. |
| doi_str_mv | 10.1248/bpb.25.472 |
| format | Article |
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Among the tested monodesmosides, kalopanxsaponin A was the most potent inhibitor of NO production, and it also significantly decreased PGE2 and TNF-α release. Consistent with these observations, the expression level of inducible NO synthase (iNOS) and cyclooxygenase (COX)-2 enzyme was inhibited by kalopanxsaponin A in a concentration-dependent manner. Thus, this study suggests that kalopanaxsaponin A-mediated inhibition of iNOS, COX-2 expression, and TNF-α release may be one of the mechanisms responsible for the anti-inflammatory effects of the stem bark of Kalopanax pictus NAKAI.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.25.472</identifier><identifier>PMID: 11995927</identifier><language>eng</language><publisher>Tokyo: The Pharmaceutical Society of Japan</publisher><subject><![CDATA[Animals ; Anti-Inflammatory Agents, Non-Steroidal - chemistry ; Anti-Inflammatory Agents, Non-Steroidal - isolation & purification ; Anti-Inflammatory Agents, Non-Steroidal - toxicity ; Araliaceae - chemistry ; Biological and medical sciences ; Cell Line ; Cell Survival - drug effects ; COX-2 ; Cyclooxygenase 2 ; Dinoprostone - antagonists & inhibitors ; Dinoprostone - biosynthesis ; Dose-Response Relationship, Drug ; Enzyme Induction - drug effects ; General pharmacology ; hederagenin monodesmoside ; iNOS and TNF-α ; Isoenzymes - antagonists & inhibitors ; Isoenzymes - biosynthesis ; lipopolysaccharide ; Lipopolysaccharides - antagonists & inhibitors ; Lipopolysaccharides - pharmacology ; macrophage ; Macrophages - drug effects ; Macrophages - enzymology ; Macrophages - metabolism ; Medical sciences ; Mice ; nitric oxide ; Nitric Oxide Synthase - antagonists & inhibitors ; Nitric Oxide Synthase - biosynthesis ; Nitric Oxide Synthase Type II ; Nitrites - metabolism ; Oleanolic Acid - analogs & derivatives ; Oleanolic Acid - chemistry ; Oleanolic Acid - isolation & purification ; Oleanolic Acid - toxicity ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Plant Bark - chemistry ; prostaglandin E2 ; Prostaglandin-Endoperoxide Synthases - biosynthesis ; Saponins - chemistry ; Saponins - isolation & purification ; Saponins - toxicity ; Tumor Necrosis Factor-alpha - antagonists & inhibitors ; Tumor Necrosis Factor-alpha - biosynthesis]]></subject><ispartof>Biological and Pharmaceutical Bulletin, 2002, Vol.25(4), pp.472-476</ispartof><rights>2002 The Pharmaceutical Society of Japan</rights><rights>2002 INIST-CNRS</rights><rights>Copyright Japan Science and Technology Agency 2002</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c649t-4b941a33e2e3e068b3e5ffc00d513bedabba8771473097eb7493b4ae1c87f5a33</citedby><cites>FETCH-LOGICAL-c649t-4b941a33e2e3e068b3e5ffc00d513bedabba8771473097eb7493b4ae1c87f5a33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,1877,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13642721$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11995927$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Young-Kwan</creatorcontrib><creatorcontrib>Kim, Ryung-Gue</creatorcontrib><creatorcontrib>Park, So-Jung</creatorcontrib><creatorcontrib>Ha, Joo-Hun</creatorcontrib><creatorcontrib>Choi, Jong-Won</creatorcontrib><creatorcontrib>Park, Hee-Juhn</creatorcontrib><creatorcontrib>Lee, Kyung-Tae</creatorcontrib><title>In Vitro Antiinflammatory Activity of Kalopanaxsaponin A Isolated from Kalopanax pictus in Murine Macrophage RAW 264.7 Cells</title><title>Biological & pharmaceutical bulletin</title><addtitle>Biol Pharm Bull</addtitle><description>In the present study, effects of various hederagenin monodesmosides isolated from the stem bark of Kalopanax pictus NAKAI, such as hederagenin, δ-hederin, kalopanaxsaponin A, kalopanaxsaponin I, and sapindoside C, have been evaluated on lipopolysaccharide (LPS)-induced nitric oxide (NO), prostaglandin E2 (PGE2) and tumor necrosis factor-α (TNF-α) release by the macrophage cell line RAW 264.7. Among the tested monodesmosides, kalopanxsaponin A was the most potent inhibitor of NO production, and it also significantly decreased PGE2 and TNF-α release. Consistent with these observations, the expression level of inducible NO synthase (iNOS) and cyclooxygenase (COX)-2 enzyme was inhibited by kalopanxsaponin A in a concentration-dependent manner. Thus, this study suggests that kalopanaxsaponin A-mediated inhibition of iNOS, COX-2 expression, and TNF-α release may be one of the mechanisms responsible for the anti-inflammatory effects of the stem bark of Kalopanax pictus NAKAI.</description><subject>Animals</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - chemistry</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - isolation & purification</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - toxicity</subject><subject>Araliaceae - chemistry</subject><subject>Biological and medical sciences</subject><subject>Cell Line</subject><subject>Cell Survival - drug effects</subject><subject>COX-2</subject><subject>Cyclooxygenase 2</subject><subject>Dinoprostone - antagonists & inhibitors</subject><subject>Dinoprostone - biosynthesis</subject><subject>Dose-Response Relationship, Drug</subject><subject>Enzyme Induction - drug effects</subject><subject>General pharmacology</subject><subject>hederagenin monodesmoside</subject><subject>iNOS and TNF-α</subject><subject>Isoenzymes - antagonists & inhibitors</subject><subject>Isoenzymes - biosynthesis</subject><subject>lipopolysaccharide</subject><subject>Lipopolysaccharides - antagonists & inhibitors</subject><subject>Lipopolysaccharides - pharmacology</subject><subject>macrophage</subject><subject>Macrophages - drug effects</subject><subject>Macrophages - enzymology</subject><subject>Macrophages - metabolism</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>nitric oxide</subject><subject>Nitric Oxide Synthase - antagonists & inhibitors</subject><subject>Nitric Oxide Synthase - biosynthesis</subject><subject>Nitric Oxide Synthase Type II</subject><subject>Nitrites - metabolism</subject><subject>Oleanolic Acid - analogs & derivatives</subject><subject>Oleanolic Acid - chemistry</subject><subject>Oleanolic Acid - isolation & purification</subject><subject>Oleanolic Acid - toxicity</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Plant Bark - chemistry</subject><subject>prostaglandin E2</subject><subject>Prostaglandin-Endoperoxide Synthases - biosynthesis</subject><subject>Saponins - chemistry</subject><subject>Saponins - isolation & purification</subject><subject>Saponins - toxicity</subject><subject>Tumor Necrosis Factor-alpha - antagonists & inhibitors</subject><subject>Tumor Necrosis Factor-alpha - biosynthesis</subject><issn>0918-6158</issn><issn>1347-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0MuKFDEUBuAgitMzuvEBJCBuBqrNrSqVlRSNl8YZBPGyLE7SKSdNVVImKbHBhzfSTfcmWeTL-Q8_Qi8oWVMm2jd61mtWr4Vkj9CKciGrmtH6MVoRRduqoXV7ha5T2hNCJGH8KbqiVKlaMblCf7cef3c5Btz57JwfRpgmyCEecGey--3yAYcBf4IxzODhT4I5eOdxh7cpjJDtDg8xTBeAZ2fyknAx90t03uJ7MDHMD_DT4i_dD8wasZZ4Y8cxPUNPBhiTfX66b9C39---bj5Wd58_bDfdXWUaoXIltBIUOLfMckuaVnNbD4MhZFdTru0OtIZWSiokJ0paLYXiWoClppVDXT7eoFfHuXMMvxabcr8PS_QlsqdCKKpaReqibo-qrJtStEM_RzdBPPSU9P-L7kvRPav7UnTBL08jFz3Z3YWemi3g9QlAMjAOEbxx6eJ4I5hktLi3R7dPuVR0BhCzM6M9Zx6PEn1-MQ8Qe-v5P6unnM4</recordid><startdate>20020401</startdate><enddate>20020401</enddate><creator>Kim, Young-Kwan</creator><creator>Kim, Ryung-Gue</creator><creator>Park, So-Jung</creator><creator>Ha, Joo-Hun</creator><creator>Choi, Jong-Won</creator><creator>Park, Hee-Juhn</creator><creator>Lee, Kyung-Tae</creator><general>The Pharmaceutical Society of Japan</general><general>Maruzen</general><general>Japan Science and Technology Agency</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope></search><sort><creationdate>20020401</creationdate><title>In Vitro Antiinflammatory Activity of Kalopanaxsaponin A Isolated from Kalopanax pictus in Murine Macrophage RAW 264.7 Cells</title><author>Kim, Young-Kwan ; Kim, Ryung-Gue ; Park, So-Jung ; Ha, Joo-Hun ; Choi, Jong-Won ; Park, Hee-Juhn ; Lee, Kyung-Tae</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c649t-4b941a33e2e3e068b3e5ffc00d513bedabba8771473097eb7493b4ae1c87f5a33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - chemistry</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - isolation & purification</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - toxicity</topic><topic>Araliaceae - chemistry</topic><topic>Biological and medical sciences</topic><topic>Cell Line</topic><topic>Cell Survival - drug effects</topic><topic>COX-2</topic><topic>Cyclooxygenase 2</topic><topic>Dinoprostone - antagonists & inhibitors</topic><topic>Dinoprostone - biosynthesis</topic><topic>Dose-Response Relationship, Drug</topic><topic>Enzyme Induction - drug effects</topic><topic>General pharmacology</topic><topic>hederagenin monodesmoside</topic><topic>iNOS and TNF-α</topic><topic>Isoenzymes - antagonists & inhibitors</topic><topic>Isoenzymes - biosynthesis</topic><topic>lipopolysaccharide</topic><topic>Lipopolysaccharides - antagonists & inhibitors</topic><topic>Lipopolysaccharides - pharmacology</topic><topic>macrophage</topic><topic>Macrophages - drug effects</topic><topic>Macrophages - enzymology</topic><topic>Macrophages - metabolism</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>nitric oxide</topic><topic>Nitric Oxide Synthase - antagonists & inhibitors</topic><topic>Nitric Oxide Synthase - biosynthesis</topic><topic>Nitric Oxide Synthase Type II</topic><topic>Nitrites - metabolism</topic><topic>Oleanolic Acid - analogs & derivatives</topic><topic>Oleanolic Acid - chemistry</topic><topic>Oleanolic Acid - isolation & purification</topic><topic>Oleanolic Acid - toxicity</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Plant Bark - chemistry</topic><topic>prostaglandin E2</topic><topic>Prostaglandin-Endoperoxide Synthases - biosynthesis</topic><topic>Saponins - chemistry</topic><topic>Saponins - isolation & purification</topic><topic>Saponins - toxicity</topic><topic>Tumor Necrosis Factor-alpha - antagonists & inhibitors</topic><topic>Tumor Necrosis Factor-alpha - biosynthesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Young-Kwan</creatorcontrib><creatorcontrib>Kim, Ryung-Gue</creatorcontrib><creatorcontrib>Park, So-Jung</creatorcontrib><creatorcontrib>Ha, Joo-Hun</creatorcontrib><creatorcontrib>Choi, Jong-Won</creatorcontrib><creatorcontrib>Park, Hee-Juhn</creatorcontrib><creatorcontrib>Lee, Kyung-Tae</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Biological & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Young-Kwan</au><au>Kim, Ryung-Gue</au><au>Park, So-Jung</au><au>Ha, Joo-Hun</au><au>Choi, Jong-Won</au><au>Park, Hee-Juhn</au><au>Lee, Kyung-Tae</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In Vitro Antiinflammatory Activity of Kalopanaxsaponin A Isolated from Kalopanax pictus in Murine Macrophage RAW 264.7 Cells</atitle><jtitle>Biological & pharmaceutical bulletin</jtitle><addtitle>Biol Pharm Bull</addtitle><date>2002-04-01</date><risdate>2002</risdate><volume>25</volume><issue>4</issue><spage>472</spage><epage>476</epage><pages>472-476</pages><issn>0918-6158</issn><eissn>1347-5215</eissn><abstract>In the present study, effects of various hederagenin monodesmosides isolated from the stem bark of Kalopanax pictus NAKAI, such as hederagenin, δ-hederin, kalopanaxsaponin A, kalopanaxsaponin I, and sapindoside C, have been evaluated on lipopolysaccharide (LPS)-induced nitric oxide (NO), prostaglandin E2 (PGE2) and tumor necrosis factor-α (TNF-α) release by the macrophage cell line RAW 264.7. Among the tested monodesmosides, kalopanxsaponin A was the most potent inhibitor of NO production, and it also significantly decreased PGE2 and TNF-α release. Consistent with these observations, the expression level of inducible NO synthase (iNOS) and cyclooxygenase (COX)-2 enzyme was inhibited by kalopanxsaponin A in a concentration-dependent manner. Thus, this study suggests that kalopanaxsaponin A-mediated inhibition of iNOS, COX-2 expression, and TNF-α release may be one of the mechanisms responsible for the anti-inflammatory effects of the stem bark of Kalopanax pictus NAKAI.</abstract><cop>Tokyo</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>11995927</pmid><doi>10.1248/bpb.25.472</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Biological and Pharmaceutical Bulletin, 2002, Vol.25(4), pp.472-476 |
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| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | Animals Anti-Inflammatory Agents, Non-Steroidal - chemistry Anti-Inflammatory Agents, Non-Steroidal - isolation & purification Anti-Inflammatory Agents, Non-Steroidal - toxicity Araliaceae - chemistry Biological and medical sciences Cell Line Cell Survival - drug effects COX-2 Cyclooxygenase 2 Dinoprostone - antagonists & inhibitors Dinoprostone - biosynthesis Dose-Response Relationship, Drug Enzyme Induction - drug effects General pharmacology hederagenin monodesmoside iNOS and TNF-α Isoenzymes - antagonists & inhibitors Isoenzymes - biosynthesis lipopolysaccharide Lipopolysaccharides - antagonists & inhibitors Lipopolysaccharides - pharmacology macrophage Macrophages - drug effects Macrophages - enzymology Macrophages - metabolism Medical sciences Mice nitric oxide Nitric Oxide Synthase - antagonists & inhibitors Nitric Oxide Synthase - biosynthesis Nitric Oxide Synthase Type II Nitrites - metabolism Oleanolic Acid - analogs & derivatives Oleanolic Acid - chemistry Oleanolic Acid - isolation & purification Oleanolic Acid - toxicity Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Bark - chemistry prostaglandin E2 Prostaglandin-Endoperoxide Synthases - biosynthesis Saponins - chemistry Saponins - isolation & purification Saponins - toxicity Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - biosynthesis |
| title | In Vitro Antiinflammatory Activity of Kalopanaxsaponin A Isolated from Kalopanax pictus in Murine Macrophage RAW 264.7 Cells |
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