Effects of Extract Derived from Eriobotrya japonica on Liver Function Improvement in Rats
Eriobotrya japonica is considered a medicinal plant, and its leaves (Eriobotrya folia) have been used to treat skin diseases, as well as to relieve inflammation, pain, coughing, and sputa. In our evaluation of the pharmacological efficacy of the seed extracts, constituents of the seeds were found to...
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| Veröffentlicht in: | Biological & pharmaceutical bulletin 2002, Vol.25(8), pp.1053-1057 |
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| creator | Nishioka, Yutaka Yoshioka, Saburo Kusunose, Masahiko Cui, Tailin Hamada, Atuhide Ono, Masahide Miyamura, Mituhiko Kyotani, Shojiro |
| description | Eriobotrya japonica is considered a medicinal plant, and its leaves (Eriobotrya folia) have been used to treat skin diseases, as well as to relieve inflammation, pain, coughing, and sputa. In our evaluation of the pharmacological efficacy of the seed extracts, constituents of the seeds were found to contain the unsaturated fatty acids linolenic and linoleic acids and the sterol β-sitosterol in the 70% EtOH and the MeOH extracts. The seed extracts were orally administered to rats with dimethylnitrosamine-induced hepatopathy, and blood L-asparate aminotransferase (AST) and L-alanine aminotransferase (ALT) levels, liver retinoid level, and hydroxyproline level were measured. Liver fibrosis rates calculated after Azan-Mallory staining and evaluation of the liver function-improving effects of extracts were showed that AST, ALT, and hydroxyproline levels and liver fibrosis rates were significantly lower, and retinoid levels were significantly higher in hepatopathic rats treated with 70% EtOH and MeOH extracts of the seed than in water-treated control rats. This suggests that the positive effect on liver function of the extracts varies depending on the extracting solvent used. 70% EtOH and MeOH extract of the seeds inhibited the development of liver fibrosis in hepatopathic rats, thus exhibiting potent improvement. The unsaturated linolenic and linoleic acids and the sterol β-sitosterol contained in these extracts may also contribute to the improvement of liver function. |
| doi_str_mv | 10.1248/bpb.25.1053 |
| format | Article |
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In our evaluation of the pharmacological efficacy of the seed extracts, constituents of the seeds were found to contain the unsaturated fatty acids linolenic and linoleic acids and the sterol β-sitosterol in the 70% EtOH and the MeOH extracts. The seed extracts were orally administered to rats with dimethylnitrosamine-induced hepatopathy, and blood L-asparate aminotransferase (AST) and L-alanine aminotransferase (ALT) levels, liver retinoid level, and hydroxyproline level were measured. Liver fibrosis rates calculated after Azan-Mallory staining and evaluation of the liver function-improving effects of extracts were showed that AST, ALT, and hydroxyproline levels and liver fibrosis rates were significantly lower, and retinoid levels were significantly higher in hepatopathic rats treated with 70% EtOH and MeOH extracts of the seed than in water-treated control rats. This suggests that the positive effect on liver function of the extracts varies depending on the extracting solvent used. 70% EtOH and MeOH extract of the seeds inhibited the development of liver fibrosis in hepatopathic rats, thus exhibiting potent improvement. The unsaturated linolenic and linoleic acids and the sterol β-sitosterol contained in these extracts may also contribute to the improvement of liver function.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.25.1053</identifier><identifier>PMID: 12186409</identifier><language>eng</language><publisher>Tokyo: The Pharmaceutical Society of Japan</publisher><subject>Animals ; Biological and medical sciences ; dimethylnitrosamine ; Dimethylnitrosamine - toxicity ; Eriobotrya ; Eriobotrya japonica ; General pharmacology ; hydroxyproline ; Liver - drug effects ; Liver - pathology ; Liver - physiology ; Liver Cirrhosis - chemically induced ; Liver Cirrhosis - pathology ; Liver Cirrhosis - prevention & control ; liver fibrosis ; Male ; Medical sciences ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Plant Extracts - isolation & purification ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; Rats ; Rats, Wistar ; retinoid ; Seeds</subject><ispartof>Biological and Pharmaceutical Bulletin, 2002, Vol.25(8), pp.1053-1057</ispartof><rights>2002 The Pharmaceutical Society of Japan</rights><rights>2002 INIST-CNRS</rights><rights>Copyright Japan Science and Technology Agency 2002</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c653t-290eceb4e4e22598bb023dc01b33945a14b3360ac1985de5bb937dbea3b1b1f53</citedby><cites>FETCH-LOGICAL-c653t-290eceb4e4e22598bb023dc01b33945a14b3360ac1985de5bb937dbea3b1b1f53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13880425$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12186409$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nishioka, Yutaka</creatorcontrib><creatorcontrib>Yoshioka, Saburo</creatorcontrib><creatorcontrib>Kusunose, Masahiko</creatorcontrib><creatorcontrib>Cui, Tailin</creatorcontrib><creatorcontrib>Hamada, Atuhide</creatorcontrib><creatorcontrib>Ono, Masahide</creatorcontrib><creatorcontrib>Miyamura, Mituhiko</creatorcontrib><creatorcontrib>Kyotani, Shojiro</creatorcontrib><title>Effects of Extract Derived from Eriobotrya japonica on Liver Function Improvement in Rats</title><title>Biological & pharmaceutical bulletin</title><addtitle>Biol Pharm Bull</addtitle><description>Eriobotrya japonica is considered a medicinal plant, and its leaves (Eriobotrya folia) have been used to treat skin diseases, as well as to relieve inflammation, pain, coughing, and sputa. In our evaluation of the pharmacological efficacy of the seed extracts, constituents of the seeds were found to contain the unsaturated fatty acids linolenic and linoleic acids and the sterol β-sitosterol in the 70% EtOH and the MeOH extracts. The seed extracts were orally administered to rats with dimethylnitrosamine-induced hepatopathy, and blood L-asparate aminotransferase (AST) and L-alanine aminotransferase (ALT) levels, liver retinoid level, and hydroxyproline level were measured. Liver fibrosis rates calculated after Azan-Mallory staining and evaluation of the liver function-improving effects of extracts were showed that AST, ALT, and hydroxyproline levels and liver fibrosis rates were significantly lower, and retinoid levels were significantly higher in hepatopathic rats treated with 70% EtOH and MeOH extracts of the seed than in water-treated control rats. This suggests that the positive effect on liver function of the extracts varies depending on the extracting solvent used. 70% EtOH and MeOH extract of the seeds inhibited the development of liver fibrosis in hepatopathic rats, thus exhibiting potent improvement. The unsaturated linolenic and linoleic acids and the sterol β-sitosterol contained in these extracts may also contribute to the improvement of liver function.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>dimethylnitrosamine</subject><subject>Dimethylnitrosamine - toxicity</subject><subject>Eriobotrya</subject><subject>Eriobotrya japonica</subject><subject>General pharmacology</subject><subject>hydroxyproline</subject><subject>Liver - drug effects</subject><subject>Liver - pathology</subject><subject>Liver - physiology</subject><subject>Liver Cirrhosis - chemically induced</subject><subject>Liver Cirrhosis - pathology</subject><subject>Liver Cirrhosis - prevention & control</subject><subject>liver fibrosis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Plant Extracts - isolation & purification</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>retinoid</subject><subject>Seeds</subject><issn>0918-6158</issn><issn>1347-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEtrGzEUhUVoSZy0q-yLoHRVxtXVYyztGlLnAYZCaRddCUlzJx3jGbmSHJp_Xxk7yeY-uB_3HA4hl8DmwKX-4rd-ztUcmBInZAZCLhrFQb0hM2ZANy0ofUbOc14zxhaMi1NyBhx0K5mZkd_LvsdQMo09Xf4ryYVCv2EaHrGjfYojXaYh-ljSk6Nrt43TEByNE11VItGb3RTKUNf7cZviI444FTpM9Icr-R1527tNxvfHfkF-3Sx_Xt81q--399dXqya0SpSGG4YBvUSJnCujva8Wu8DAC2GkciDr0DIXwGjVofLeiEXn0QkPHnolLsjHw9_q4O8Oc7HruEtTlbQgpQEjjG4r9flAhRRzTtjbbRpGl54sMLuP0dYYLVd2H2OlPxx_7vyI3St7zK0Cn46Ay8Ft-uSmMORXTmjNJN-b-3rg1rm4B3wBXCpD2OCzqD6UvfbLKfxxyeIk_gODepFp</recordid><startdate>20020801</startdate><enddate>20020801</enddate><creator>Nishioka, Yutaka</creator><creator>Yoshioka, Saburo</creator><creator>Kusunose, Masahiko</creator><creator>Cui, Tailin</creator><creator>Hamada, Atuhide</creator><creator>Ono, Masahide</creator><creator>Miyamura, Mituhiko</creator><creator>Kyotani, Shojiro</creator><general>The Pharmaceutical Society of Japan</general><general>Maruzen</general><general>Japan Science and Technology Agency</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope></search><sort><creationdate>20020801</creationdate><title>Effects of Extract Derived from Eriobotrya japonica on Liver Function Improvement in Rats</title><author>Nishioka, Yutaka ; Yoshioka, Saburo ; Kusunose, Masahiko ; Cui, Tailin ; Hamada, Atuhide ; Ono, Masahide ; Miyamura, Mituhiko ; Kyotani, Shojiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c653t-290eceb4e4e22598bb023dc01b33945a14b3360ac1985de5bb937dbea3b1b1f53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>dimethylnitrosamine</topic><topic>Dimethylnitrosamine - toxicity</topic><topic>Eriobotrya</topic><topic>Eriobotrya japonica</topic><topic>General pharmacology</topic><topic>hydroxyproline</topic><topic>Liver - drug effects</topic><topic>Liver - pathology</topic><topic>Liver - physiology</topic><topic>Liver Cirrhosis - chemically induced</topic><topic>Liver Cirrhosis - pathology</topic><topic>Liver Cirrhosis - prevention & control</topic><topic>liver fibrosis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Plant Extracts - isolation & purification</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - therapeutic use</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>retinoid</topic><topic>Seeds</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nishioka, Yutaka</creatorcontrib><creatorcontrib>Yoshioka, Saburo</creatorcontrib><creatorcontrib>Kusunose, Masahiko</creatorcontrib><creatorcontrib>Cui, Tailin</creatorcontrib><creatorcontrib>Hamada, Atuhide</creatorcontrib><creatorcontrib>Ono, Masahide</creatorcontrib><creatorcontrib>Miyamura, Mituhiko</creatorcontrib><creatorcontrib>Kyotani, Shojiro</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Biological & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nishioka, Yutaka</au><au>Yoshioka, Saburo</au><au>Kusunose, Masahiko</au><au>Cui, Tailin</au><au>Hamada, Atuhide</au><au>Ono, Masahide</au><au>Miyamura, Mituhiko</au><au>Kyotani, Shojiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Extract Derived from Eriobotrya japonica on Liver Function Improvement in Rats</atitle><jtitle>Biological & pharmaceutical bulletin</jtitle><addtitle>Biol Pharm Bull</addtitle><date>2002-08-01</date><risdate>2002</risdate><volume>25</volume><issue>8</issue><spage>1053</spage><epage>1057</epage><pages>1053-1057</pages><issn>0918-6158</issn><eissn>1347-5215</eissn><abstract>Eriobotrya japonica is considered a medicinal plant, and its leaves (Eriobotrya folia) have been used to treat skin diseases, as well as to relieve inflammation, pain, coughing, and sputa. In our evaluation of the pharmacological efficacy of the seed extracts, constituents of the seeds were found to contain the unsaturated fatty acids linolenic and linoleic acids and the sterol β-sitosterol in the 70% EtOH and the MeOH extracts. The seed extracts were orally administered to rats with dimethylnitrosamine-induced hepatopathy, and blood L-asparate aminotransferase (AST) and L-alanine aminotransferase (ALT) levels, liver retinoid level, and hydroxyproline level were measured. Liver fibrosis rates calculated after Azan-Mallory staining and evaluation of the liver function-improving effects of extracts were showed that AST, ALT, and hydroxyproline levels and liver fibrosis rates were significantly lower, and retinoid levels were significantly higher in hepatopathic rats treated with 70% EtOH and MeOH extracts of the seed than in water-treated control rats. This suggests that the positive effect on liver function of the extracts varies depending on the extracting solvent used. 70% EtOH and MeOH extract of the seeds inhibited the development of liver fibrosis in hepatopathic rats, thus exhibiting potent improvement. The unsaturated linolenic and linoleic acids and the sterol β-sitosterol contained in these extracts may also contribute to the improvement of liver function.</abstract><cop>Tokyo</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>12186409</pmid><doi>10.1248/bpb.25.1053</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Biological and medical sciences dimethylnitrosamine Dimethylnitrosamine - toxicity Eriobotrya Eriobotrya japonica General pharmacology hydroxyproline Liver - drug effects Liver - pathology Liver - physiology Liver Cirrhosis - chemically induced Liver Cirrhosis - pathology Liver Cirrhosis - prevention & control liver fibrosis Male Medical sciences Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Extracts - isolation & purification Plant Extracts - pharmacology Plant Extracts - therapeutic use Rats Rats, Wistar retinoid Seeds |
| title | Effects of Extract Derived from Eriobotrya japonica on Liver Function Improvement in Rats |
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