Saeng-Maek-San, a Medicinal Herb Complex, Protects Liver Cell Damage Induced by Alcohol
The effect of treatment with Saeng-Maek-San (SMS) Complex (SMS1 or SMS2) upon rat hepatocytes exposed to alcohol was investigated. We compared the serum biochemistry and liver histology of rats administered both alcohol and SMS to control rats treated with alcohol alone. SMS treatment resulted in a...
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| Veröffentlicht in: | Biological & pharmaceutical bulletin 2002, Vol.25(11), pp.1451-1455 |
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| creator | Park, Kap Joo Lee, Min Jung Kang, Hyunmin Kim, Kang Sung Lee, Sang-Han Cho, Ikhyun Lee, Hyung Hoan |
| description | The effect of treatment with Saeng-Maek-San (SMS) Complex (SMS1 or SMS2) upon rat hepatocytes exposed to alcohol was investigated. We compared the serum biochemistry and liver histology of rats administered both alcohol and SMS to control rats treated with alcohol alone. SMS treatment resulted in a significant reduction in the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and triglycerides (TG) compared to the control rats. In contrast, expression levels of alcohol dehydrogenase (ADH) were increased. Electron microscopy indicated that administration of SMS preserved the structure of organelles, including the nucleus and mitochondria. In addition, lipid droplets and secondary lysosomes were observed in the control rats. These data suggest that SMS represents an excellent candidate for protection of rat hepatocytes from alcohol-mediated damage. |
| doi_str_mv | 10.1248/bpb.25.1451 |
| format | Article |
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We compared the serum biochemistry and liver histology of rats administered both alcohol and SMS to control rats treated with alcohol alone. SMS treatment resulted in a significant reduction in the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and triglycerides (TG) compared to the control rats. In contrast, expression levels of alcohol dehydrogenase (ADH) were increased. Electron microscopy indicated that administration of SMS preserved the structure of organelles, including the nucleus and mitochondria. In addition, lipid droplets and secondary lysosomes were observed in the control rats. These data suggest that SMS represents an excellent candidate for protection of rat hepatocytes from alcohol-mediated damage.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.25.1451</identifier><identifier>PMID: 12419958</identifier><language>eng</language><publisher>Tokyo: The Pharmaceutical Society of Japan</publisher><subject>alcohol ; Animals ; Biological and medical sciences ; Ethanol - toxicity ; General pharmacology ; Korea ; Liver - drug effects ; Liver - enzymology ; Liver - pathology ; Male ; Medical sciences ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Plant Extracts - isolation & purification ; Plant Extracts - pharmacology ; Plants, Medicinal ; rat liver cell ; Rats ; Rats, Sprague-Dawley ; Saeng-Maek-San</subject><ispartof>Biological and Pharmaceutical Bulletin, 2002, Vol.25(11), pp.1451-1455</ispartof><rights>2002 The Pharmaceutical Society of Japan</rights><rights>2003 INIST-CNRS</rights><rights>Copyright Japan Science and Technology Agency 2002</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c655t-a00d4c7334fd22374cc209a8e59fa5a1aa1843ce087928757962a8b0bbd988663</citedby><cites>FETCH-LOGICAL-c655t-a00d4c7334fd22374cc209a8e59fa5a1aa1843ce087928757962a8b0bbd988663</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1881,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14366010$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12419958$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Park, Kap Joo</creatorcontrib><creatorcontrib>Lee, Min Jung</creatorcontrib><creatorcontrib>Kang, Hyunmin</creatorcontrib><creatorcontrib>Kim, Kang Sung</creatorcontrib><creatorcontrib>Lee, Sang-Han</creatorcontrib><creatorcontrib>Cho, Ikhyun</creatorcontrib><creatorcontrib>Lee, Hyung Hoan</creatorcontrib><title>Saeng-Maek-San, a Medicinal Herb Complex, Protects Liver Cell Damage Induced by Alcohol</title><title>Biological & pharmaceutical bulletin</title><addtitle>Biol Pharm Bull</addtitle><description>The effect of treatment with Saeng-Maek-San (SMS) Complex (SMS1 or SMS2) upon rat hepatocytes exposed to alcohol was investigated. We compared the serum biochemistry and liver histology of rats administered both alcohol and SMS to control rats treated with alcohol alone. SMS treatment resulted in a significant reduction in the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and triglycerides (TG) compared to the control rats. In contrast, expression levels of alcohol dehydrogenase (ADH) were increased. Electron microscopy indicated that administration of SMS preserved the structure of organelles, including the nucleus and mitochondria. In addition, lipid droplets and secondary lysosomes were observed in the control rats. These data suggest that SMS represents an excellent candidate for protection of rat hepatocytes from alcohol-mediated damage.</description><subject>alcohol</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Ethanol - toxicity</subject><subject>General pharmacology</subject><subject>Korea</subject><subject>Liver - drug effects</subject><subject>Liver - enzymology</subject><subject>Liver - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Plant Extracts - isolation & purification</subject><subject>Plant Extracts - pharmacology</subject><subject>Plants, Medicinal</subject><subject>rat liver cell</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Saeng-Maek-San</subject><issn>0918-6158</issn><issn>1347-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0E1P3DAQBmCroipb2hN3ZAn1VLL1Z2IfYfsB0qJWohVHa-JMIIs3WexsVf59vdpouXgOfmbGfgk55WzOhTJf6k09F3rOleZvyIxLVRVacH1EZsxyU5Rcm2PyPqUVY6xiQr4jx7mPW6vNjNzfAfYPxS3gU3EH_QUFeotN57seAr3GWNPFsN4E_HdBf8VhRD8muuz-YqQLDIF-hTU8IL3pm63HhtYv9DL44XEIH8jbFkLCj1M9IX--f_u9uC6WP3_cLC6XhS-1HgtgrFG-klK1jRCyUt4LZsGgti1o4ADcKOmRmcoKU-nKlgJMzeq6scaUpTwh5_u5mzg8bzGNbjVsY358clwpy23-ss7q8175OKQUsXWb2K0hvjjO3C5El0N0QrtdiFmfTTO39RqbVzullsGnCUDyENoIve_Sq1OyLBln2V3t3SqNOaYDgDh2PuBhKZ_O3fbDpX-E6LCX_wG-1Y5K</recordid><startdate>20021101</startdate><enddate>20021101</enddate><creator>Park, Kap Joo</creator><creator>Lee, Min Jung</creator><creator>Kang, Hyunmin</creator><creator>Kim, Kang Sung</creator><creator>Lee, Sang-Han</creator><creator>Cho, Ikhyun</creator><creator>Lee, Hyung Hoan</creator><general>The Pharmaceutical Society of Japan</general><general>Maruzen</general><general>Japan Science and Technology Agency</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope></search><sort><creationdate>20021101</creationdate><title>Saeng-Maek-San, a Medicinal Herb Complex, Protects Liver Cell Damage Induced by Alcohol</title><author>Park, Kap Joo ; Lee, Min Jung ; Kang, Hyunmin ; Kim, Kang Sung ; Lee, Sang-Han ; Cho, Ikhyun ; Lee, Hyung Hoan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c655t-a00d4c7334fd22374cc209a8e59fa5a1aa1843ce087928757962a8b0bbd988663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>alcohol</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Ethanol - toxicity</topic><topic>General pharmacology</topic><topic>Korea</topic><topic>Liver - drug effects</topic><topic>Liver - enzymology</topic><topic>Liver - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. 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| subjects | alcohol Animals Biological and medical sciences Ethanol - toxicity General pharmacology Korea Liver - drug effects Liver - enzymology Liver - pathology Male Medical sciences Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Extracts - isolation & purification Plant Extracts - pharmacology Plants, Medicinal rat liver cell Rats Rats, Sprague-Dawley Saeng-Maek-San |
| title | Saeng-Maek-San, a Medicinal Herb Complex, Protects Liver Cell Damage Induced by Alcohol |
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