Role of Endogenous Endotoxin on Tumor Necrosis Factor-Hypersensitivity Caused by D-Galactosamine Challenge

We examined the role of endotoxin in the mechanism of recombinant human tumor necrosis factor (rhTNF)-hypersensitivity caused by D-galactosamine (GalN). We used polymyxin B, an antibiotic with anti-endotoxin activity, to determine the participation of endogenous endotoxin. The glycogen and blood glu...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2000/01/01, Vol.23(1), pp.116-118
Hauptverfasser:	SAKAGUCHI, Shuhei, FURUSAWA, Shinobu, YOKOTA, Katsushi, SASAKI, Ken-ichi, TAKAYANAGI, Motoaki, TAKAYANAGI, Yoshio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Blood Glucose - drug effects Blood Glucose - metabolism Body Temperature - drug effects endotoxin Endotoxins - toxicity galactosamine Galactosamine - administration & dosage Hypersensitivity - etiology Hypersensitivity - immunology hypersensivity Liver Glycogen - metabolism Male Medical sciences Mice Pharmacology. Drug treatments polymyxin B Polymyxin B - pharmacology Recombinant Proteins - immunology Rectum tumor necrosis factor Tumor Necrosis Factor-alpha - administration & dosage Tumor Necrosis Factor-alpha - immunology
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