Reduction in Blood Free Carnitine Levels in Association with Changes in Sodium Valproate (VPA) Disposition in Epileptic Patients Treated with VPA and Other Anti-epileptic Drugs

Reduction in the blood free carnitine (FC) level as a side effect of sodium valproate (VPA) given epiletic patients was pharmacokinetically studied in connection with changes in the VPA disposition. The serum FC level in patients taking at least one of phenobarbital (PB), phenytoin (PHT) and/or carb...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 1997/01/15, Vol.20(1), pp.91-93
Hauptverfasser:	HIRAOKA, Atsushi, ARATO, Teruyo, TOMINAGA, Itaru
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged anti-epileptic drug Anticonvulsants - pharmacokinetics Anticonvulsants. Antiepileptics. Antiparkinson agents Biological and medical sciences Carnitine - blood Epilepsy - drug therapy Female free carnitine Humans level-dose ratio Male Medical sciences Middle Aged Neuropharmacology Pharmacology. Drug treatments side effect sodium valproate Valproic Acid - adverse effects Valproic Acid - pharmacokinetics
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