Antitumorigenic Activities of Chalcones. I. Inhibitory Effects of Chalcone Derivatives on 32Pi-Incorporation into Phospholipids of HeLa Cells Promoted by 12-O-Tetradecanoyl-phorbol 13-Acetate (TPA)
More than forty chalcone derivatives were synthesized to examine their structure-activity relationship against tumorigenesis. As a primary screening test, the inhibitory activities of the chalcones for the 32Pi-incorporation into phospholipids of HeLa cells enhanced by 12-O-tetradecanoyl-phorbol 13-...
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| Veröffentlicht in: | Biological & pharmaceutical bulletin 1995/12/15, Vol.18(12), pp.1710-1713 |
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| container_issue | 12 |
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| container_title | Biological & pharmaceutical bulletin |
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| creator | IWATA, Susumu NISHINO, Takeshi NAGATA, Nobuyuki SATOMI, Yoshiko NISHINO, Hoyoku SHIBATA, Shoji |
| description | More than forty chalcone derivatives were synthesized to examine their structure-activity relationship against tumorigenesis. As a primary screening test, the inhibitory activities of the chalcones for the 32Pi-incorporation into phospholipids of HeLa cells enhanced by 12-O-tetradecanoyl-phorbol 13-acetate (TPA) were examined. 3-Hydroxy-chalcone derivatives possessing methyl group in 3'-, 4'-, or 2'-position and isoliquiritigenin homologs showed potent inhibitory activities in the phosphorylation test, which suggests their antitumorigenic effects. |
| doi_str_mv | 10.1248/bpb.18.1710 |
| format | Article |
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As a primary screening test, the inhibitory activities of the chalcones for the 32Pi-incorporation into phospholipids of HeLa cells enhanced by 12-O-tetradecanoyl-phorbol 13-acetate (TPA) were examined. 3-Hydroxy-chalcone derivatives possessing methyl group in 3'-, 4'-, or 2'-position and isoliquiritigenin homologs showed potent inhibitory activities in the phosphorylation test, which suggests their antitumorigenic effects.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.18.1710</identifier><identifier>PMID: 8787793</identifier><language>eng</language><publisher>Tokyo: The Pharmaceutical Society of Japan</publisher><subject>3-hydroxy-3'-methylchalcone ; 3-hydroxy-4'-methylchalcone ; Animals ; Antineoplastic agents ; Antineoplastic Agents - pharmacology ; antitumor promoting activity ; Biological and medical sciences ; Chalcone - analogs & derivatives ; Chalcone - pharmacology ; Chalcones ; Chick Embryo ; Fibroblasts - drug effects ; General aspects ; HeLa Cells - drug effects ; Humans ; isoliquiritigenin ; Medical sciences ; Pharmacology. Drug treatments ; Phospholipids - metabolism ; Phosphorus Radioisotopes ; structure-activity relationship ; Tetradecanoylphorbol Acetate - antagonists & inhibitors</subject><ispartof>Biological and Pharmaceutical Bulletin, 1995/12/15, Vol.18(12), pp.1710-1713</ispartof><rights>The Pharmaceutical Society of Japan</rights><rights>1996 INIST-CNRS</rights><rights>Copyright Japan Science and Technology Agency 1995</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3540-a617f5f502e9081a679c97c46e54a4a7cc9b7b01df6bfb99301aaf08b2c8c2c83</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2996553$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8787793$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>IWATA, Susumu</creatorcontrib><creatorcontrib>NISHINO, Takeshi</creatorcontrib><creatorcontrib>NAGATA, Nobuyuki</creatorcontrib><creatorcontrib>SATOMI, Yoshiko</creatorcontrib><creatorcontrib>NISHINO, Hoyoku</creatorcontrib><creatorcontrib>SHIBATA, Shoji</creatorcontrib><title>Antitumorigenic Activities of Chalcones. I. Inhibitory Effects of Chalcone Derivatives on 32Pi-Incorporation into Phospholipids of HeLa Cells Promoted by 12-O-Tetradecanoyl-phorbol 13-Acetate (TPA)</title><title>Biological & pharmaceutical bulletin</title><addtitle>Biol Pharm Bull</addtitle><description>More than forty chalcone derivatives were synthesized to examine their structure-activity relationship against tumorigenesis. As a primary screening test, the inhibitory activities of the chalcones for the 32Pi-incorporation into phospholipids of HeLa cells enhanced by 12-O-tetradecanoyl-phorbol 13-acetate (TPA) were examined. 3-Hydroxy-chalcone derivatives possessing methyl group in 3'-, 4'-, or 2'-position and isoliquiritigenin homologs showed potent inhibitory activities in the phosphorylation test, which suggests their antitumorigenic effects.</description><subject>3-hydroxy-3'-methylchalcone</subject><subject>3-hydroxy-4'-methylchalcone</subject><subject>Animals</subject><subject>Antineoplastic agents</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>antitumor promoting activity</subject><subject>Biological and medical sciences</subject><subject>Chalcone - analogs & derivatives</subject><subject>Chalcone - pharmacology</subject><subject>Chalcones</subject><subject>Chick Embryo</subject><subject>Fibroblasts - drug effects</subject><subject>General aspects</subject><subject>HeLa Cells - drug effects</subject><subject>Humans</subject><subject>isoliquiritigenin</subject><subject>Medical sciences</subject><subject>Pharmacology. 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I. Inhibitory Effects of Chalcone Derivatives on 32Pi-Incorporation into Phospholipids of HeLa Cells Promoted by 12-O-Tetradecanoyl-phorbol 13-Acetate (TPA)</title><author>IWATA, Susumu ; NISHINO, Takeshi ; NAGATA, Nobuyuki ; SATOMI, Yoshiko ; NISHINO, Hoyoku ; SHIBATA, Shoji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3540-a617f5f502e9081a679c97c46e54a4a7cc9b7b01df6bfb99301aaf08b2c8c2c83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>3-hydroxy-3'-methylchalcone</topic><topic>3-hydroxy-4'-methylchalcone</topic><topic>Animals</topic><topic>Antineoplastic agents</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>antitumor promoting activity</topic><topic>Biological and medical sciences</topic><topic>Chalcone - analogs & derivatives</topic><topic>Chalcone - pharmacology</topic><topic>Chalcones</topic><topic>Chick Embryo</topic><topic>Fibroblasts - drug effects</topic><topic>General aspects</topic><topic>HeLa Cells - drug effects</topic><topic>Humans</topic><topic>isoliquiritigenin</topic><topic>Medical sciences</topic><topic>Pharmacology. 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As a primary screening test, the inhibitory activities of the chalcones for the 32Pi-incorporation into phospholipids of HeLa cells enhanced by 12-O-tetradecanoyl-phorbol 13-acetate (TPA) were examined. 3-Hydroxy-chalcone derivatives possessing methyl group in 3'-, 4'-, or 2'-position and isoliquiritigenin homologs showed potent inhibitory activities in the phosphorylation test, which suggests their antitumorigenic effects.</abstract><cop>Tokyo</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>8787793</pmid><doi>10.1248/bpb.18.1710</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| source | J-STAGE Free; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Free Full-Text Journals in Chemistry |
| subjects | 3-hydroxy-3'-methylchalcone 3-hydroxy-4'-methylchalcone Animals Antineoplastic agents Antineoplastic Agents - pharmacology antitumor promoting activity Biological and medical sciences Chalcone - analogs & derivatives Chalcone - pharmacology Chalcones Chick Embryo Fibroblasts - drug effects General aspects HeLa Cells - drug effects Humans isoliquiritigenin Medical sciences Pharmacology. Drug treatments Phospholipids - metabolism Phosphorus Radioisotopes structure-activity relationship Tetradecanoylphorbol Acetate - antagonists & inhibitors |
| title | Antitumorigenic Activities of Chalcones. I. Inhibitory Effects of Chalcone Derivatives on 32Pi-Incorporation into Phospholipids of HeLa Cells Promoted by 12-O-Tetradecanoyl-phorbol 13-Acetate (TPA) |
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