Hinokitiol Induces Differentiation of Teratocarcinoma F9 Cells
Hinokitiol, a constituent of the wood of Chamaecyparis taiwanensis, was found to induce differentiation of teratocarcinoma F9 cells. When examined by the agar-overlay method, in which expression of plasminogen activator as a differentiation marker protein was detected, this compound exhibited a dose...
Gespeichert in:
| Veröffentlicht in: | Biological & pharmaceutical bulletin 1995/11/15, Vol.18(11), pp.1576-1579 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1579 |
|---|---|
| container_issue | 11 |
| container_start_page | 1576 |
| container_title | Biological & pharmaceutical bulletin |
| container_volume | 18 |
| creator | MUTO, Norio DOTA, Atsuyoshi TANAKA, Tetsuya ITOH, Norio OKABE, Masaru INADA, Akira NAKANISHI, Tsutomu TANAKA, Keiichi |
| description | Hinokitiol, a constituent of the wood of Chamaecyparis taiwanensis, was found to induce differentiation of teratocarcinoma F9 cells. When examined by the agar-overlay method, in which expression of plasminogen activator as a differentiation marker protein was detected, this compound exhibited a dose-and time-dependent induction. Induction of differentiation by hinokitiol occurred irreversibly and required its addition for more than 12h. Among its structure-related compounds tested, tropolone and two colchicine-related compounds exerted potent activities comparable to that of hinokitiol. These findings indicate that free tropolone structure in the molecules plays an essential role in inducing differentiation of F9 cells. Hinokitiol showed a strong inhibitory effect on DNA synthesis in very early stages of culture, suggesting that this effect may be responsible for triggering differentiation of F9 cells. |
| doi_str_mv | 10.1248/bpb.18.1576 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_1449162796</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3120324421</sourcerecordid><originalsourceid>FETCH-LOGICAL-c608t-3802a1d674013426f771ec83b46521b4e379e8fa957a81dd33477b3fec5fbee73</originalsourceid><addsrcrecordid>eNo9kDFPwzAQhS0EKqUwMSNFgg2l-GInthckVCitVImlzJbjnCElTYqdDvx7XFq63En3Pt27e4RcAx1DxuVDuSnHIMeQi-KEDIFxkeYZ5KdkSBXItIBcnpOLEFaUUkEzNiADmSvGJRuSx1nddl91X3dNMm-rrcWQPNfOoce2r02ct0nnkiV603fWeBvxtUmmKplg04RLcuZME_Dq0EfkffqynMzSxdvrfPK0SG1BZZ8ySTMDVSE4jedlhRMC0EpW8iJeWnJkQqF0RuXCSKgqFn8QJXNoc1ciCjYit_u9G999bzH0etVtfRstNXCuoMiEKiJ1v6es70Lw6PTG12vjfzRQvYtKx6g0SL2LKtI3h53bco3VkT1kE_W7g26CNY3zprV1OGKZ4jnNeMSme2wVevOBR934vrYN7ixBKfZnC_81-h8B-2m8xpb9As1wh7E</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1449162796</pqid></control><display><type>article</type><title>Hinokitiol Induces Differentiation of Teratocarcinoma F9 Cells</title><source>MEDLINE</source><source>J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Free Full-Text Journals in Chemistry</source><creator>MUTO, Norio ; DOTA, Atsuyoshi ; TANAKA, Tetsuya ; ITOH, Norio ; OKABE, Masaru ; INADA, Akira ; NAKANISHI, Tsutomu ; TANAKA, Keiichi</creator><creatorcontrib>MUTO, Norio ; DOTA, Atsuyoshi ; TANAKA, Tetsuya ; ITOH, Norio ; OKABE, Masaru ; INADA, Akira ; NAKANISHI, Tsutomu ; TANAKA, Keiichi</creatorcontrib><description>Hinokitiol, a constituent of the wood of Chamaecyparis taiwanensis, was found to induce differentiation of teratocarcinoma F9 cells. When examined by the agar-overlay method, in which expression of plasminogen activator as a differentiation marker protein was detected, this compound exhibited a dose-and time-dependent induction. Induction of differentiation by hinokitiol occurred irreversibly and required its addition for more than 12h. Among its structure-related compounds tested, tropolone and two colchicine-related compounds exerted potent activities comparable to that of hinokitiol. These findings indicate that free tropolone structure in the molecules plays an essential role in inducing differentiation of F9 cells. Hinokitiol showed a strong inhibitory effect on DNA synthesis in very early stages of culture, suggesting that this effect may be responsible for triggering differentiation of F9 cells.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.18.1576</identifier><identifier>PMID: 8593483</identifier><language>eng</language><publisher>Tokyo: The Pharmaceutical Society of Japan</publisher><subject>Animals ; Antineoplastic Agents, Phytogenic - pharmacology ; Biological and medical sciences ; Biomarkers ; Butyrates - pharmacology ; Butyric Acid ; Cell Differentiation - drug effects ; differentiation ; DNA, Neoplasm - biosynthesis ; Embryonal Carcinoma Stem Cells ; General pharmacology ; hinokitiol ; Medical sciences ; Mice ; Monoterpenes ; Neoplastic Stem Cells - cytology ; Neoplastic Stem Cells - drug effects ; Neoplastic Stem Cells - metabolism ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; plasminogen activator ; Plasminogen Activators - biosynthesis ; Structure-Activity Relationship ; teratocarcinoma ; tropolone ; Tropolone - analogs & derivatives ; Tropolone - pharmacology ; Tumor Cells, Cultured</subject><ispartof>Biological and Pharmaceutical Bulletin, 1995/11/15, Vol.18(11), pp.1576-1579</ispartof><rights>The Pharmaceutical Society of Japan</rights><rights>1996 INIST-CNRS</rights><rights>Copyright Japan Science and Technology Agency 1995</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c608t-3802a1d674013426f771ec83b46521b4e379e8fa957a81dd33477b3fec5fbee73</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2945024$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8593483$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MUTO, Norio</creatorcontrib><creatorcontrib>DOTA, Atsuyoshi</creatorcontrib><creatorcontrib>TANAKA, Tetsuya</creatorcontrib><creatorcontrib>ITOH, Norio</creatorcontrib><creatorcontrib>OKABE, Masaru</creatorcontrib><creatorcontrib>INADA, Akira</creatorcontrib><creatorcontrib>NAKANISHI, Tsutomu</creatorcontrib><creatorcontrib>TANAKA, Keiichi</creatorcontrib><title>Hinokitiol Induces Differentiation of Teratocarcinoma F9 Cells</title><title>Biological & pharmaceutical bulletin</title><addtitle>Biol Pharm Bull</addtitle><description>Hinokitiol, a constituent of the wood of Chamaecyparis taiwanensis, was found to induce differentiation of teratocarcinoma F9 cells. When examined by the agar-overlay method, in which expression of plasminogen activator as a differentiation marker protein was detected, this compound exhibited a dose-and time-dependent induction. Induction of differentiation by hinokitiol occurred irreversibly and required its addition for more than 12h. Among its structure-related compounds tested, tropolone and two colchicine-related compounds exerted potent activities comparable to that of hinokitiol. These findings indicate that free tropolone structure in the molecules plays an essential role in inducing differentiation of F9 cells. Hinokitiol showed a strong inhibitory effect on DNA synthesis in very early stages of culture, suggesting that this effect may be responsible for triggering differentiation of F9 cells.</description><subject>Animals</subject><subject>Antineoplastic Agents, Phytogenic - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>Butyrates - pharmacology</subject><subject>Butyric Acid</subject><subject>Cell Differentiation - drug effects</subject><subject>differentiation</subject><subject>DNA, Neoplasm - biosynthesis</subject><subject>Embryonal Carcinoma Stem Cells</subject><subject>General pharmacology</subject><subject>hinokitiol</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Monoterpenes</subject><subject>Neoplastic Stem Cells - cytology</subject><subject>Neoplastic Stem Cells - drug effects</subject><subject>Neoplastic Stem Cells - metabolism</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>plasminogen activator</subject><subject>Plasminogen Activators - biosynthesis</subject><subject>Structure-Activity Relationship</subject><subject>teratocarcinoma</subject><subject>tropolone</subject><subject>Tropolone - analogs & derivatives</subject><subject>Tropolone - pharmacology</subject><subject>Tumor Cells, Cultured</subject><issn>0918-6158</issn><issn>1347-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kDFPwzAQhS0EKqUwMSNFgg2l-GInthckVCitVImlzJbjnCElTYqdDvx7XFq63En3Pt27e4RcAx1DxuVDuSnHIMeQi-KEDIFxkeYZ5KdkSBXItIBcnpOLEFaUUkEzNiADmSvGJRuSx1nddl91X3dNMm-rrcWQPNfOoce2r02ct0nnkiV603fWeBvxtUmmKplg04RLcuZME_Dq0EfkffqynMzSxdvrfPK0SG1BZZ8ySTMDVSE4jedlhRMC0EpW8iJeWnJkQqF0RuXCSKgqFn8QJXNoc1ciCjYit_u9G999bzH0etVtfRstNXCuoMiEKiJ1v6es70Lw6PTG12vjfzRQvYtKx6g0SL2LKtI3h53bco3VkT1kE_W7g26CNY3zprV1OGKZ4jnNeMSme2wVevOBR934vrYN7ixBKfZnC_81-h8B-2m8xpb9As1wh7E</recordid><startdate>1995</startdate><enddate>1995</enddate><creator>MUTO, Norio</creator><creator>DOTA, Atsuyoshi</creator><creator>TANAKA, Tetsuya</creator><creator>ITOH, Norio</creator><creator>OKABE, Masaru</creator><creator>INADA, Akira</creator><creator>NAKANISHI, Tsutomu</creator><creator>TANAKA, Keiichi</creator><general>The Pharmaceutical Society of Japan</general><general>Maruzen</general><general>Japan Science and Technology Agency</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope></search><sort><creationdate>1995</creationdate><title>Hinokitiol Induces Differentiation of Teratocarcinoma F9 Cells</title><author>MUTO, Norio ; DOTA, Atsuyoshi ; TANAKA, Tetsuya ; ITOH, Norio ; OKABE, Masaru ; INADA, Akira ; NAKANISHI, Tsutomu ; TANAKA, Keiichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c608t-3802a1d674013426f771ec83b46521b4e379e8fa957a81dd33477b3fec5fbee73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Animals</topic><topic>Antineoplastic Agents, Phytogenic - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Biomarkers</topic><topic>Butyrates - pharmacology</topic><topic>Butyric Acid</topic><topic>Cell Differentiation - drug effects</topic><topic>differentiation</topic><topic>DNA, Neoplasm - biosynthesis</topic><topic>Embryonal Carcinoma Stem Cells</topic><topic>General pharmacology</topic><topic>hinokitiol</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Monoterpenes</topic><topic>Neoplastic Stem Cells - cytology</topic><topic>Neoplastic Stem Cells - drug effects</topic><topic>Neoplastic Stem Cells - metabolism</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>plasminogen activator</topic><topic>Plasminogen Activators - biosynthesis</topic><topic>Structure-Activity Relationship</topic><topic>teratocarcinoma</topic><topic>tropolone</topic><topic>Tropolone - analogs & derivatives</topic><topic>Tropolone - pharmacology</topic><topic>Tumor Cells, Cultured</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MUTO, Norio</creatorcontrib><creatorcontrib>DOTA, Atsuyoshi</creatorcontrib><creatorcontrib>TANAKA, Tetsuya</creatorcontrib><creatorcontrib>ITOH, Norio</creatorcontrib><creatorcontrib>OKABE, Masaru</creatorcontrib><creatorcontrib>INADA, Akira</creatorcontrib><creatorcontrib>NAKANISHI, Tsutomu</creatorcontrib><creatorcontrib>TANAKA, Keiichi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Biological & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MUTO, Norio</au><au>DOTA, Atsuyoshi</au><au>TANAKA, Tetsuya</au><au>ITOH, Norio</au><au>OKABE, Masaru</au><au>INADA, Akira</au><au>NAKANISHI, Tsutomu</au><au>TANAKA, Keiichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hinokitiol Induces Differentiation of Teratocarcinoma F9 Cells</atitle><jtitle>Biological & pharmaceutical bulletin</jtitle><addtitle>Biol Pharm Bull</addtitle><date>1995</date><risdate>1995</risdate><volume>18</volume><issue>11</issue><spage>1576</spage><epage>1579</epage><pages>1576-1579</pages><issn>0918-6158</issn><eissn>1347-5215</eissn><abstract>Hinokitiol, a constituent of the wood of Chamaecyparis taiwanensis, was found to induce differentiation of teratocarcinoma F9 cells. When examined by the agar-overlay method, in which expression of plasminogen activator as a differentiation marker protein was detected, this compound exhibited a dose-and time-dependent induction. Induction of differentiation by hinokitiol occurred irreversibly and required its addition for more than 12h. Among its structure-related compounds tested, tropolone and two colchicine-related compounds exerted potent activities comparable to that of hinokitiol. These findings indicate that free tropolone structure in the molecules plays an essential role in inducing differentiation of F9 cells. Hinokitiol showed a strong inhibitory effect on DNA synthesis in very early stages of culture, suggesting that this effect may be responsible for triggering differentiation of F9 cells.</abstract><cop>Tokyo</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>8593483</pmid><doi>10.1248/bpb.18.1576</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0918-6158 |
| ispartof | Biological and Pharmaceutical Bulletin, 1995/11/15, Vol.18(11), pp.1576-1579 |
| issn | 0918-6158 1347-5215 |
| language | eng |
| recordid | cdi_proquest_journals_1449162796 |
| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Free Full-Text Journals in Chemistry |
| subjects | Animals Antineoplastic Agents, Phytogenic - pharmacology Biological and medical sciences Biomarkers Butyrates - pharmacology Butyric Acid Cell Differentiation - drug effects differentiation DNA, Neoplasm - biosynthesis Embryonal Carcinoma Stem Cells General pharmacology hinokitiol Medical sciences Mice Monoterpenes Neoplastic Stem Cells - cytology Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - metabolism Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments plasminogen activator Plasminogen Activators - biosynthesis Structure-Activity Relationship teratocarcinoma tropolone Tropolone - analogs & derivatives Tropolone - pharmacology Tumor Cells, Cultured |
| title | Hinokitiol Induces Differentiation of Teratocarcinoma F9 Cells |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-12T16%3A52%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Hinokitiol%20Induces%20Differentiation%20of%20Teratocarcinoma%20F9%20Cells&rft.jtitle=Biological%20&%20pharmaceutical%20bulletin&rft.au=MUTO,%20Norio&rft.date=1995&rft.volume=18&rft.issue=11&rft.spage=1576&rft.epage=1579&rft.pages=1576-1579&rft.issn=0918-6158&rft.eissn=1347-5215&rft_id=info:doi/10.1248/bpb.18.1576&rft_dat=%3Cproquest_cross%3E3120324421%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1449162796&rft_id=info:pmid/8593483&rfr_iscdi=true |