Population Analysis of the Dose-Dependent Pharmacokinetics of Zonisamide in Epileptic Patients

The pharmacokinetics of zonisamide was studied using routine therapeutic drug monitoring data from 68 epileptic patients. The 266 serum concentration data at steady-state after repetitive oral administration were analyzed using the nonlinear mixed effects model (NONMEM) program designed for estimati...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 1994/02/15, Vol.17(2), pp.323-326
Hauptverfasser:	HASHIMOTO, Yukiya, ODANI, Atsuko, TANIGAWARA, Yusuke, YASUHARA, Masato, OKUNO, Takehiko, HORI, Ryohei
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adolescent Adult Anticonvulsants - administration & dosage Anticonvulsants - blood Anticonvulsants - pharmacokinetics Anticonvulsants. Antiepileptics. Antiparkinson agents Biological and medical sciences Biological Availability carbamazepine Carbamazepine - pharmacology Child Child, Preschool Chromatography, High Pressure Liquid Cohort Studies dose-dependent kinetics Dose-Response Relationship, Drug drug interaction Drug Interactions Epilepsy - blood Female Humans Isoxazoles - administration & dosage Isoxazoles - blood Isoxazoles - pharmacokinetics Male Medical sciences Neuropharmacology NONMEM Pharmacology. Drug treatments population pharmacokinetics Software Zonisamide
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