Effects of Fluidity and Vesicle Size on Antitumor Activity and Myelosuppressive Activity of Liposomes Loaded with Daunorubicin
The effects of fluidity and vesicle size on the antitumor activity and myelosuppressive activity of liposomes loaded with daunorubicin, an anthracycline antitumor drug, were investigated in Yoshida sarcoma-bearing rats. Liposomes composed of egg phosphatidylcholine (EPC) or hydrogenated egg phosphat...
Gespeichert in:
| Veröffentlicht in: | Biological & pharmaceutical bulletin 1994/07/15, Vol.17(7), pp.935-939 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 939 |
|---|---|
| container_issue | 7 |
| container_start_page | 935 |
| container_title | Biological & pharmaceutical bulletin |
| container_volume | 17 |
| creator | NAGAYASU, Atsushi SHIMOOKA, Takashi KINOUCHI, Yoshihito UCHIYAMA, Kazuko TAKEICHI, Yoh'ichiro KIWADA, Hiroshi |
| description | The effects of fluidity and vesicle size on the antitumor activity and myelosuppressive activity of liposomes loaded with daunorubicin, an anthracycline antitumor drug, were investigated in Yoshida sarcoma-bearing rats. Liposomes composed of egg phosphatidylcholine (EPC) or hydrogenated egg phosphatidylcholine (HEPC), cholesterol and dicetyl phosphate in a molar ratio of 5 : 4 : 1 were injected intravenously into rats 5 d after subcutaneous inoculation of Yoshida sarcoma. At non-effect dosage in free drug, HEPC-liposomes with a diameter of 58 or 142 nm showed the greatest inhibitory effect against Yoshida sarcoma among liposomes tested, whereas larger ones (272 nm) had weaker effect. Small EPC-liposomes (57 nm) had no effect. Larger HEPC-liposomes (especially 142 nm) greatly decreased the number of peripheral white blood cell compared with free drug at the same dose, indicating relatively strong myelosuppressive toxicity. However, small EPC-and HEPC-liposomes with a diameter of 57 and 58 nm, respectively, showed toxic effects comparable to that of free drug. Examination of the dose-dependency of therapeutic effects and toxicity indicated encapsulation of daunorubicin in the small HEPC-liposomes to enhance the therapeutic index about 3 times that of free drug. These findings indicate the possibility of using small HEPC-liposome as a drug carrier for targeting solid tumors. |
| doi_str_mv | 10.1248/bpb.17.935 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_1449156889</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3120259091</sourcerecordid><originalsourceid>FETCH-LOGICAL-c501t-3fddd3f085495f5edda46bad04cd8cfc94977dcff91ed02223ae493cf24cefe13</originalsourceid><addsrcrecordid>eNpFkM-LEzEYhoMoa129eBcCehKmJpOkkxxLd1eFigd_XEMm-eKmTCdjklmpB_92U1rrJV_geXhfeBF6ScmStly-66d-SbulYuIRWlDGu0a0VDxGC6KobFZUyKfoWc47QkhHWnaFrmT9MkkX6M-t92BLxtHju2EOLpQDNqPD3yEHOwD-En4DjiNejyWUeR8TXtsSHv5pnw4wxDxPU4KcwwP8pzVwG6aY4x4y3kbjwOFfodzjGzOPMc19sGF8jp54M2R4cb7X6Nvd7dfNh2b7-f3HzXrbWEFoaZh3zjFPpOBKeAHOGb7qjSPcOmm9VVx1nbPeKwqOtG3LDHDFrG-5BQ-UXaPXp9wpxZ8z5KJ3cU5jrdSUc0XFSkpVrbcny6aYcwKvpxT2Jh00Jfq4tK5La9rpunSVX50j534P7qKep638zZmbbM3gkxltyBeNcUo71lZtc9J2uZgfcOEmleP-x0aqFDu2dqenll-ovTdJw8j-AkdIoLY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1449156889</pqid></control><display><type>article</type><title>Effects of Fluidity and Vesicle Size on Antitumor Activity and Myelosuppressive Activity of Liposomes Loaded with Daunorubicin</title><source>J-STAGE Free</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Free Full-Text Journals in Chemistry</source><creator>NAGAYASU, Atsushi ; SHIMOOKA, Takashi ; KINOUCHI, Yoshihito ; UCHIYAMA, Kazuko ; TAKEICHI, Yoh'ichiro ; KIWADA, Hiroshi</creator><creatorcontrib>NAGAYASU, Atsushi ; SHIMOOKA, Takashi ; KINOUCHI, Yoshihito ; UCHIYAMA, Kazuko ; TAKEICHI, Yoh'ichiro ; KIWADA, Hiroshi</creatorcontrib><description>The effects of fluidity and vesicle size on the antitumor activity and myelosuppressive activity of liposomes loaded with daunorubicin, an anthracycline antitumor drug, were investigated in Yoshida sarcoma-bearing rats. Liposomes composed of egg phosphatidylcholine (EPC) or hydrogenated egg phosphatidylcholine (HEPC), cholesterol and dicetyl phosphate in a molar ratio of 5 : 4 : 1 were injected intravenously into rats 5 d after subcutaneous inoculation of Yoshida sarcoma. At non-effect dosage in free drug, HEPC-liposomes with a diameter of 58 or 142 nm showed the greatest inhibitory effect against Yoshida sarcoma among liposomes tested, whereas larger ones (272 nm) had weaker effect. Small EPC-liposomes (57 nm) had no effect. Larger HEPC-liposomes (especially 142 nm) greatly decreased the number of peripheral white blood cell compared with free drug at the same dose, indicating relatively strong myelosuppressive toxicity. However, small EPC-and HEPC-liposomes with a diameter of 57 and 58 nm, respectively, showed toxic effects comparable to that of free drug. Examination of the dose-dependency of therapeutic effects and toxicity indicated encapsulation of daunorubicin in the small HEPC-liposomes to enhance the therapeutic index about 3 times that of free drug. These findings indicate the possibility of using small HEPC-liposome as a drug carrier for targeting solid tumors.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.17.935</identifier><identifier>PMID: 8000381</identifier><language>eng</language><publisher>Tokyo: The Pharmaceutical Society of Japan</publisher><subject>Animals ; Antineoplastic agents ; Biological and medical sciences ; Bone Marrow - drug effects ; Chemotherapy ; Daunorubicin - administration & dosage ; Daunorubicin - pharmacology ; Daunorubicin - toxicity ; Dose-Response Relationship, Drug ; Drug Carriers ; fluidity ; liposome ; Liposomes ; Male ; Medical sciences ; Membrane Fluidity ; myelosuppression ; Pharmacology. Drug treatments ; Rats ; Sarcoma, Yoshida - drug therapy ; tumor growth inhibition ; vesicle size ; Yoshida sarcoma</subject><ispartof>Biological and Pharmaceutical Bulletin, 1994/07/15, Vol.17(7), pp.935-939</ispartof><rights>The Pharmaceutical Society of Japan</rights><rights>1995 INIST-CNRS</rights><rights>Copyright Japan Science and Technology Agency 1994</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c501t-3fddd3f085495f5edda46bad04cd8cfc94977dcff91ed02223ae493cf24cefe13</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3411732$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8000381$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>NAGAYASU, Atsushi</creatorcontrib><creatorcontrib>SHIMOOKA, Takashi</creatorcontrib><creatorcontrib>KINOUCHI, Yoshihito</creatorcontrib><creatorcontrib>UCHIYAMA, Kazuko</creatorcontrib><creatorcontrib>TAKEICHI, Yoh'ichiro</creatorcontrib><creatorcontrib>KIWADA, Hiroshi</creatorcontrib><title>Effects of Fluidity and Vesicle Size on Antitumor Activity and Myelosuppressive Activity of Liposomes Loaded with Daunorubicin</title><title>Biological & pharmaceutical bulletin</title><addtitle>Biol Pharm Bull</addtitle><description>The effects of fluidity and vesicle size on the antitumor activity and myelosuppressive activity of liposomes loaded with daunorubicin, an anthracycline antitumor drug, were investigated in Yoshida sarcoma-bearing rats. Liposomes composed of egg phosphatidylcholine (EPC) or hydrogenated egg phosphatidylcholine (HEPC), cholesterol and dicetyl phosphate in a molar ratio of 5 : 4 : 1 were injected intravenously into rats 5 d after subcutaneous inoculation of Yoshida sarcoma. At non-effect dosage in free drug, HEPC-liposomes with a diameter of 58 or 142 nm showed the greatest inhibitory effect against Yoshida sarcoma among liposomes tested, whereas larger ones (272 nm) had weaker effect. Small EPC-liposomes (57 nm) had no effect. Larger HEPC-liposomes (especially 142 nm) greatly decreased the number of peripheral white blood cell compared with free drug at the same dose, indicating relatively strong myelosuppressive toxicity. However, small EPC-and HEPC-liposomes with a diameter of 57 and 58 nm, respectively, showed toxic effects comparable to that of free drug. Examination of the dose-dependency of therapeutic effects and toxicity indicated encapsulation of daunorubicin in the small HEPC-liposomes to enhance the therapeutic index about 3 times that of free drug. These findings indicate the possibility of using small HEPC-liposome as a drug carrier for targeting solid tumors.</description><subject>Animals</subject><subject>Antineoplastic agents</subject><subject>Biological and medical sciences</subject><subject>Bone Marrow - drug effects</subject><subject>Chemotherapy</subject><subject>Daunorubicin - administration & dosage</subject><subject>Daunorubicin - pharmacology</subject><subject>Daunorubicin - toxicity</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Carriers</subject><subject>fluidity</subject><subject>liposome</subject><subject>Liposomes</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Membrane Fluidity</subject><subject>myelosuppression</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Sarcoma, Yoshida - drug therapy</subject><subject>tumor growth inhibition</subject><subject>vesicle size</subject><subject>Yoshida sarcoma</subject><issn>0918-6158</issn><issn>1347-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkM-LEzEYhoMoa129eBcCehKmJpOkkxxLd1eFigd_XEMm-eKmTCdjklmpB_92U1rrJV_geXhfeBF6ScmStly-66d-SbulYuIRWlDGu0a0VDxGC6KobFZUyKfoWc47QkhHWnaFrmT9MkkX6M-t92BLxtHju2EOLpQDNqPD3yEHOwD-En4DjiNejyWUeR8TXtsSHv5pnw4wxDxPU4KcwwP8pzVwG6aY4x4y3kbjwOFfodzjGzOPMc19sGF8jp54M2R4cb7X6Nvd7dfNh2b7-f3HzXrbWEFoaZh3zjFPpOBKeAHOGb7qjSPcOmm9VVx1nbPeKwqOtG3LDHDFrG-5BQ-UXaPXp9wpxZ8z5KJ3cU5jrdSUc0XFSkpVrbcny6aYcwKvpxT2Jh00Jfq4tK5La9rpunSVX50j534P7qKep638zZmbbM3gkxltyBeNcUo71lZtc9J2uZgfcOEmleP-x0aqFDu2dqenll-ovTdJw8j-AkdIoLY</recordid><startdate>19940701</startdate><enddate>19940701</enddate><creator>NAGAYASU, Atsushi</creator><creator>SHIMOOKA, Takashi</creator><creator>KINOUCHI, Yoshihito</creator><creator>UCHIYAMA, Kazuko</creator><creator>TAKEICHI, Yoh'ichiro</creator><creator>KIWADA, Hiroshi</creator><general>The Pharmaceutical Society of Japan</general><general>Maruzen</general><general>Japan Science and Technology Agency</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope></search><sort><creationdate>19940701</creationdate><title>Effects of Fluidity and Vesicle Size on Antitumor Activity and Myelosuppressive Activity of Liposomes Loaded with Daunorubicin</title><author>NAGAYASU, Atsushi ; SHIMOOKA, Takashi ; KINOUCHI, Yoshihito ; UCHIYAMA, Kazuko ; TAKEICHI, Yoh'ichiro ; KIWADA, Hiroshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c501t-3fddd3f085495f5edda46bad04cd8cfc94977dcff91ed02223ae493cf24cefe13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Animals</topic><topic>Antineoplastic agents</topic><topic>Biological and medical sciences</topic><topic>Bone Marrow - drug effects</topic><topic>Chemotherapy</topic><topic>Daunorubicin - administration & dosage</topic><topic>Daunorubicin - pharmacology</topic><topic>Daunorubicin - toxicity</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Carriers</topic><topic>fluidity</topic><topic>liposome</topic><topic>Liposomes</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Membrane Fluidity</topic><topic>myelosuppression</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Sarcoma, Yoshida - drug therapy</topic><topic>tumor growth inhibition</topic><topic>vesicle size</topic><topic>Yoshida sarcoma</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>NAGAYASU, Atsushi</creatorcontrib><creatorcontrib>SHIMOOKA, Takashi</creatorcontrib><creatorcontrib>KINOUCHI, Yoshihito</creatorcontrib><creatorcontrib>UCHIYAMA, Kazuko</creatorcontrib><creatorcontrib>TAKEICHI, Yoh'ichiro</creatorcontrib><creatorcontrib>KIWADA, Hiroshi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Biological & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>NAGAYASU, Atsushi</au><au>SHIMOOKA, Takashi</au><au>KINOUCHI, Yoshihito</au><au>UCHIYAMA, Kazuko</au><au>TAKEICHI, Yoh'ichiro</au><au>KIWADA, Hiroshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Fluidity and Vesicle Size on Antitumor Activity and Myelosuppressive Activity of Liposomes Loaded with Daunorubicin</atitle><jtitle>Biological & pharmaceutical bulletin</jtitle><addtitle>Biol Pharm Bull</addtitle><date>1994-07-01</date><risdate>1994</risdate><volume>17</volume><issue>7</issue><spage>935</spage><epage>939</epage><pages>935-939</pages><issn>0918-6158</issn><eissn>1347-5215</eissn><abstract>The effects of fluidity and vesicle size on the antitumor activity and myelosuppressive activity of liposomes loaded with daunorubicin, an anthracycline antitumor drug, were investigated in Yoshida sarcoma-bearing rats. Liposomes composed of egg phosphatidylcholine (EPC) or hydrogenated egg phosphatidylcholine (HEPC), cholesterol and dicetyl phosphate in a molar ratio of 5 : 4 : 1 were injected intravenously into rats 5 d after subcutaneous inoculation of Yoshida sarcoma. At non-effect dosage in free drug, HEPC-liposomes with a diameter of 58 or 142 nm showed the greatest inhibitory effect against Yoshida sarcoma among liposomes tested, whereas larger ones (272 nm) had weaker effect. Small EPC-liposomes (57 nm) had no effect. Larger HEPC-liposomes (especially 142 nm) greatly decreased the number of peripheral white blood cell compared with free drug at the same dose, indicating relatively strong myelosuppressive toxicity. However, small EPC-and HEPC-liposomes with a diameter of 57 and 58 nm, respectively, showed toxic effects comparable to that of free drug. Examination of the dose-dependency of therapeutic effects and toxicity indicated encapsulation of daunorubicin in the small HEPC-liposomes to enhance the therapeutic index about 3 times that of free drug. These findings indicate the possibility of using small HEPC-liposome as a drug carrier for targeting solid tumors.</abstract><cop>Tokyo</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>8000381</pmid><doi>10.1248/bpb.17.935</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0918-6158 |
| ispartof | Biological and Pharmaceutical Bulletin, 1994/07/15, Vol.17(7), pp.935-939 |
| issn | 0918-6158 1347-5215 |
| language | eng |
| recordid | cdi_proquest_journals_1449156889 |
| source | J-STAGE Free; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Free Full-Text Journals in Chemistry |
| subjects | Animals Antineoplastic agents Biological and medical sciences Bone Marrow - drug effects Chemotherapy Daunorubicin - administration & dosage Daunorubicin - pharmacology Daunorubicin - toxicity Dose-Response Relationship, Drug Drug Carriers fluidity liposome Liposomes Male Medical sciences Membrane Fluidity myelosuppression Pharmacology. Drug treatments Rats Sarcoma, Yoshida - drug therapy tumor growth inhibition vesicle size Yoshida sarcoma |
| title | Effects of Fluidity and Vesicle Size on Antitumor Activity and Myelosuppressive Activity of Liposomes Loaded with Daunorubicin |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-10T01%3A31%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20Fluidity%20and%20Vesicle%20Size%20on%20Antitumor%20Activity%20and%20Myelosuppressive%20Activity%20of%20Liposomes%20Loaded%20with%20Daunorubicin&rft.jtitle=Biological%20&%20pharmaceutical%20bulletin&rft.au=NAGAYASU,%20Atsushi&rft.date=1994-07-01&rft.volume=17&rft.issue=7&rft.spage=935&rft.epage=939&rft.pages=935-939&rft.issn=0918-6158&rft.eissn=1347-5215&rft_id=info:doi/10.1248/bpb.17.935&rft_dat=%3Cproquest_cross%3E3120259091%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1449156889&rft_id=info:pmid/8000381&rfr_iscdi=true |