Studies on Pharmacological Activation of Human Immunoglobulin G by Chemical Modification and Active Subfragments. X. Effect of Carboxamidemethylated Fc Fragment (CM-Fc) from Human Immunoglobulin G on Delayed Type Hypersensitivity
The anti-allergic activity of the carboxamidemethylated Fc fragment (CM-Fc) from human serum immunoglobulin G (IgG) was studied using sheep red blood cell-induced delayed type hypersensitivity in mice (SRBC-DTH). CM-Fc suppressed the DTH response when administered 30 min before, or 4 h after the SRB...
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| Veröffentlicht in: | Biological & pharmaceutical bulletin 1993/09/15, Vol.16(9), pp.858-860 |
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| creator | MIMURA, Tsutomu ITOH, Masaaki SUGIYAMA, Tetsuya SUZUKI, Nobutaka NAKANISHI, Tsuyoshi TSUJIKAWA, Kazutake KOHAMA, Yasuhiro |
| description | The anti-allergic activity of the carboxamidemethylated Fc fragment (CM-Fc) from human serum immunoglobulin G (IgG) was studied using sheep red blood cell-induced delayed type hypersensitivity in mice (SRBC-DTH). CM-Fc suppressed the DTH response when administered 30 min before, or 4 h after the SRBC challenge, but not when administered 8 h or more after the challenge. The Fc fragment showed no activity. CM-Fc administration 30 min before the challenge was unable to suppress the DTH response in the cyclophosphamide (CY)-treated mice. However, adoptive transfer of splenocytes from mice treated with CM-Fc to CY-pretreated mice caused suppression of the SRBC-DTH response.These results suggest that CM-Fc suppressed the DTH response by mediating the function of CY-susceptible cells. |
| doi_str_mv | 10.1248/bpb.16.858 |
| format | Article |
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X. Effect of Carboxamidemethylated Fc Fragment (CM-Fc) from Human Immunoglobulin G on Delayed Type Hypersensitivity</title><source>J-STAGE Free</source><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Free Full-Text Journals in Chemistry</source><creator>MIMURA, Tsutomu ; ITOH, Masaaki ; SUGIYAMA, Tetsuya ; SUZUKI, Nobutaka ; NAKANISHI, Tsuyoshi ; TSUJIKAWA, Kazutake ; KOHAMA, Yasuhiro</creator><creatorcontrib>MIMURA, Tsutomu ; ITOH, Masaaki ; SUGIYAMA, Tetsuya ; SUZUKI, Nobutaka ; NAKANISHI, Tsuyoshi ; TSUJIKAWA, Kazutake ; KOHAMA, Yasuhiro</creatorcontrib><description>The anti-allergic activity of the carboxamidemethylated Fc fragment (CM-Fc) from human serum immunoglobulin G (IgG) was studied using sheep red blood cell-induced delayed type hypersensitivity in mice (SRBC-DTH). CM-Fc suppressed the DTH response when administered 30 min before, or 4 h after the SRBC challenge, but not when administered 8 h or more after the challenge. The Fc fragment showed no activity. CM-Fc administration 30 min before the challenge was unable to suppress the DTH response in the cyclophosphamide (CY)-treated mice. However, adoptive transfer of splenocytes from mice treated with CM-Fc to CY-pretreated mice caused suppression of the SRBC-DTH response.These results suggest that CM-Fc suppressed the DTH response by mediating the function of CY-susceptible cells.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.16.858</identifier><identifier>PMID: 8268851</identifier><language>eng</language><publisher>Tokyo: The Pharmaceutical Society of Japan</publisher><subject>Animals ; anti-allergic activity ; Biological and medical sciences ; carboxamidemethylated Fc ; cyclophosphamide ; Cyclophosphamide - pharmacology ; delayed type hypersensitivity ; Erythrocytes - immunology ; Histamine and antagonists. Allergy ; Humans ; Hypersensitivity, Delayed - drug therapy ; Immunoglobulin Fc Fragments - pharmacology ; Immunoglobulin Fc Fragments - therapeutic use ; Immunotherapy, Adoptive ; Medical sciences ; Mice ; Pharmacology. Drug treatments ; Sheep ; suppressor T cell</subject><ispartof>Biological and Pharmaceutical Bulletin, 1993/09/15, Vol.16(9), pp.858-860</ispartof><rights>The Pharmaceutical Society of Japan</rights><rights>1994 INIST-CNRS</rights><rights>Copyright Japan Science and Technology Agency 1993</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1882,4023,27922,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3937326$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8268851$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MIMURA, Tsutomu</creatorcontrib><creatorcontrib>ITOH, Masaaki</creatorcontrib><creatorcontrib>SUGIYAMA, Tetsuya</creatorcontrib><creatorcontrib>SUZUKI, Nobutaka</creatorcontrib><creatorcontrib>NAKANISHI, Tsuyoshi</creatorcontrib><creatorcontrib>TSUJIKAWA, Kazutake</creatorcontrib><creatorcontrib>KOHAMA, Yasuhiro</creatorcontrib><title>Studies on Pharmacological Activation of Human Immunoglobulin G by Chemical Modification and Active Subfragments. X. Effect of Carboxamidemethylated Fc Fragment (CM-Fc) from Human Immunoglobulin G on Delayed Type Hypersensitivity</title><title>Biological & pharmaceutical bulletin</title><addtitle>Biol Pharm Bull</addtitle><description>The anti-allergic activity of the carboxamidemethylated Fc fragment (CM-Fc) from human serum immunoglobulin G (IgG) was studied using sheep red blood cell-induced delayed type hypersensitivity in mice (SRBC-DTH). CM-Fc suppressed the DTH response when administered 30 min before, or 4 h after the SRBC challenge, but not when administered 8 h or more after the challenge. The Fc fragment showed no activity. CM-Fc administration 30 min before the challenge was unable to suppress the DTH response in the cyclophosphamide (CY)-treated mice. However, adoptive transfer of splenocytes from mice treated with CM-Fc to CY-pretreated mice caused suppression of the SRBC-DTH response.These results suggest that CM-Fc suppressed the DTH response by mediating the function of CY-susceptible cells.</description><subject>Animals</subject><subject>anti-allergic activity</subject><subject>Biological and medical sciences</subject><subject>carboxamidemethylated Fc</subject><subject>cyclophosphamide</subject><subject>Cyclophosphamide - pharmacology</subject><subject>delayed type hypersensitivity</subject><subject>Erythrocytes - immunology</subject><subject>Histamine and antagonists. Allergy</subject><subject>Humans</subject><subject>Hypersensitivity, Delayed - drug therapy</subject><subject>Immunoglobulin Fc Fragments - pharmacology</subject><subject>Immunoglobulin Fc Fragments - therapeutic use</subject><subject>Immunotherapy, Adoptive</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Pharmacology. Drug treatments</subject><subject>Sheep</subject><subject>suppressor T cell</subject><issn>0918-6158</issn><issn>1347-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1Uk2L1DAYLqKs4-rFuxDQgwodk6Zt0uNSd3YWdlHYFbyVJH0zk6FpxiQV-4P9H2Z2hrl5SPLC8xXyJMveErwkRcm_yL1cknrJK_4sWxBasrwqSPU8W-CG8LwmFX-ZvQphhzFmuKAX2QUvas4rssj-PsSpNxCQG9H3rfBWKDe4jVFiQFcqmt8imgQ5jdaTFSO6tXYa3WZwchrMiG6QnFG7BfskuHe90Wl6koixPzoAepik9mJjYYxhiX4u0bXWoOLBtRVeuj_Cmh4sxO08iAg9Wim0OgnQx_Y-X6lPSHtn_3eJFPcVBjEn6eO8B7ROmw8wBpPyTZxfZy-0GAK8OZ2X2Y_V9WO7zu--3dy2V3e5KlnN80ISnRbhqilxWUMluZAM0qxo05RQEia0VKwhFDOGOe4rTAvN-loLTCpFL7P3R9-9d78mCLHbucmPKbIjZdmQirK6SqzPR5byLgQPutt7Y4WfO4K7Q6FdKrQjdZcKTeR3J8tJWujP1FODCf9wwkVIHaR3HpUJZxptKKNFnWjtkbYLUWzgjAsfjRrgkEiahh5Sm-OWws-oSj-jg5H-A0Q0wxI</recordid><startdate>1993</startdate><enddate>1993</enddate><creator>MIMURA, Tsutomu</creator><creator>ITOH, Masaaki</creator><creator>SUGIYAMA, Tetsuya</creator><creator>SUZUKI, Nobutaka</creator><creator>NAKANISHI, Tsuyoshi</creator><creator>TSUJIKAWA, Kazutake</creator><creator>KOHAMA, Yasuhiro</creator><general>The Pharmaceutical Society of Japan</general><general>Maruzen</general><general>Japan Science and Technology Agency</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope></search><sort><creationdate>1993</creationdate><title>Studies on Pharmacological Activation of Human Immunoglobulin G by Chemical Modification and Active Subfragments. X. Effect of Carboxamidemethylated Fc Fragment (CM-Fc) from Human Immunoglobulin G on Delayed Type Hypersensitivity</title><author>MIMURA, Tsutomu ; ITOH, Masaaki ; SUGIYAMA, Tetsuya ; SUZUKI, Nobutaka ; NAKANISHI, Tsuyoshi ; TSUJIKAWA, Kazutake ; KOHAMA, Yasuhiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4768-2b1f2b118c94046e5b8ab7e404c3994e417afbc7913077080d5032f7d6fa015c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Animals</topic><topic>anti-allergic activity</topic><topic>Biological and medical sciences</topic><topic>carboxamidemethylated Fc</topic><topic>cyclophosphamide</topic><topic>Cyclophosphamide - pharmacology</topic><topic>delayed type hypersensitivity</topic><topic>Erythrocytes - immunology</topic><topic>Histamine and antagonists. Allergy</topic><topic>Humans</topic><topic>Hypersensitivity, Delayed - drug therapy</topic><topic>Immunoglobulin Fc Fragments - pharmacology</topic><topic>Immunoglobulin Fc Fragments - therapeutic use</topic><topic>Immunotherapy, Adoptive</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Pharmacology. 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| subjects | Animals anti-allergic activity Biological and medical sciences carboxamidemethylated Fc cyclophosphamide Cyclophosphamide - pharmacology delayed type hypersensitivity Erythrocytes - immunology Histamine and antagonists. Allergy Humans Hypersensitivity, Delayed - drug therapy Immunoglobulin Fc Fragments - pharmacology Immunoglobulin Fc Fragments - therapeutic use Immunotherapy, Adoptive Medical sciences Mice Pharmacology. Drug treatments Sheep suppressor T cell |
| title | Studies on Pharmacological Activation of Human Immunoglobulin G by Chemical Modification and Active Subfragments. X. Effect of Carboxamidemethylated Fc Fragment (CM-Fc) from Human Immunoglobulin G on Delayed Type Hypersensitivity |
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