Genetic polymorphism for IFN[gamma] +874T/A in patients with acute toxoplasmosis
INTRODUCTION: A single nucleotide polymorphism (SNP) in the gene encoding gamma interferon influences its production and is associated with severity of infectious diseases. This study aimed to evaluate the association of IFNγ+874T/A SNP with duration of disease, morbidity, and development of retinoc...
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| Veröffentlicht in: | Revista da Sociedade Brasileira de Medicina Tropical 2012-11, Vol.45 (6) |
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| container_title | Revista da Sociedade Brasileira de Medicina Tropical |
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| creator | Neves, Elizabeth de Souza Curi, André Luis Land Albuquerque, Maira Cavalcanti de Palhano-Silva, Cassius Schnel Silva, Laura Berriel da Bueno, Wendy Fernandes Amendoeira, Maria Regina dos Reis Bonecini-Almeida, Maria da Gloria Fernandes, Octavio |
| description | INTRODUCTION: A single nucleotide polymorphism (SNP) in the gene encoding gamma interferon influences its production and is associated with severity of infectious diseases. This study aimed to evaluate the association of IFNγ+874T/A SNP with duration of disease, morbidity, and development of retinochoroiditis in acute toxoplasmosis. METHODS: A case-control study was conducted among 30 patients and 90 controls. RESULTS: Although statistical associations were not confirmed, A-allele was more common among retinochoroiditis cases and prolonged illness, while T-allele was more frequent in severe disease. CONCLUSIONS: Despite few cases, the results could indicate a relation between IFNγ+874T/A single nucleotide polymorphism and clinical manifestations of toxoplasmosis. [PUBLICATION ABSTRACT] |
| doi_str_mv | 10.1590/S0037-86822012000600020 |
| format | Article |
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This study aimed to evaluate the association of IFNγ+874T/A SNP with duration of disease, morbidity, and development of retinochoroiditis in acute toxoplasmosis. METHODS: A case-control study was conducted among 30 patients and 90 controls. RESULTS: Although statistical associations were not confirmed, A-allele was more common among retinochoroiditis cases and prolonged illness, while T-allele was more frequent in severe disease. CONCLUSIONS: Despite few cases, the results could indicate a relation between IFNγ+874T/A single nucleotide polymorphism and clinical manifestations of toxoplasmosis. 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Curi, André Luis Land ; Albuquerque, Maira Cavalcanti de ; Palhano-Silva, Cassius Schnel ; Silva, Laura Berriel da ; Bueno, Wendy Fernandes ; Amendoeira, Maria Regina dos Reis ; Bonecini-Almeida, Maria da Gloria ; Fernandes, Octavio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_journals_14491513223</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Genotype & phenotype</topic><topic>Infectious diseases</topic><topic>Interferon</topic><topic>Parasitic diseases</topic><topic>Polymorphism</topic><topic>Toxoplasmosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Neves, Elizabeth de Souza</creatorcontrib><creatorcontrib>Curi, André Luis Land</creatorcontrib><creatorcontrib>Albuquerque, Maira Cavalcanti de</creatorcontrib><creatorcontrib>Palhano-Silva, Cassius Schnel</creatorcontrib><creatorcontrib>Silva, Laura Berriel da</creatorcontrib><creatorcontrib>Bueno, Wendy Fernandes</creatorcontrib><creatorcontrib>Amendoeira, Maria Regina dos Reis</creatorcontrib><creatorcontrib>Bonecini-Almeida, Maria da Gloria</creatorcontrib><creatorcontrib>Fernandes, Octavio</creatorcontrib><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Latin America & Iberia Database</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><jtitle>Revista da Sociedade Brasileira de Medicina Tropical</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Neves, Elizabeth de Souza</au><au>Curi, André Luis Land</au><au>Albuquerque, Maira Cavalcanti de</au><au>Palhano-Silva, Cassius Schnel</au><au>Silva, Laura Berriel da</au><au>Bueno, Wendy Fernandes</au><au>Amendoeira, Maria Regina dos Reis</au><au>Bonecini-Almeida, Maria da Gloria</au><au>Fernandes, Octavio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic polymorphism for IFN[gamma] +874T/A in patients with acute toxoplasmosis</atitle><jtitle>Revista da Sociedade Brasileira de Medicina Tropical</jtitle><date>2012-11-01</date><risdate>2012</risdate><volume>45</volume><issue>6</issue><issn>0037-8682</issn><eissn>1678-9849</eissn><abstract>INTRODUCTION: A single nucleotide polymorphism (SNP) in the gene encoding gamma interferon influences its production and is associated with severity of infectious diseases. 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| source | DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Genotype & phenotype Infectious diseases Interferon Parasitic diseases Polymorphism Toxoplasmosis |
| title | Genetic polymorphism for IFN[gamma] +874T/A in patients with acute toxoplasmosis |
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