Determination of digoxin hydrolyzed products in digoxin tablet and in the medium after dissolution test by HPLC

Determination of digoxin hydrolyzed products in digoxin tablet and in the medium after dissolution test by HPLC

A method for HPLC determination of digoxigenin (DO), digoxigenin monodigitoxoside(D1) and digoxigenin bisditoxoside (D2) in digoxin tablet was developed and applied to the determination of these digoxin hydrolyzed products in the chloroform extract of dissolution test solution of the tablet. Digoxin...

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Veröffentlicht in:BUNSEKI KAGAKU 1987/02/05, Vol.36(2), pp.73-76
Hauptverfasser: HAGIWARA, Teruhiko, AKIYAMA, Kazuyuki
Format: Artikel
Sprache:eng ; jpn
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determination of digoxin hy drolyzed products
digoxin
digoxin tablet
dissolution test of digoxin tablet
HPLC
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container_title BUNSEKI KAGAKU
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creator HAGIWARA, Teruhiko
AKIYAMA, Kazuyuki
description A method for HPLC determination of digoxigenin (DO), digoxigenin monodigitoxoside(D1) and digoxigenin bisditoxoside (D2) in digoxin tablet was developed and applied to the determination of these digoxin hydrolyzed products in the chloroform extract of dissolution test solution of the tablet. Digoxin hydrolyzed products were separated at 40 °C on an Inertsil ODS column by using mixed solution of acetonitrile-methanol-water (11 : 7 : 35) as mobile phase, and were detected at 225 nm. Ethyl benzoate was used as an internal standard. In six brand of tablets, D0, D1 and D2 were found to be 0.131.84, 0.160.29 and 1.604.19 μg/tab., respectively. The chloroform extract of dissolution test solution was found to contain 42.546.4% D0, 17% D1, 20% D2 and 15.720.2% digoxin.
doi_str_mv 10.2116/bunsekikagaku.36.2_73
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Digoxin hydrolyzed products were separated at 40 °C on an Inertsil ODS column by using mixed solution of acetonitrile-methanol-water (11 : 7 : 35) as mobile phase, and were detected at 225 nm. Ethyl benzoate was used as an internal standard. In six brand of tablets, D0, D1 and D2 were found to be 0.131.84, 0.160.29 and 1.604.19 μg/tab., respectively. 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Digoxin hydrolyzed products were separated at 40 °C on an Inertsil ODS column by using mixed solution of acetonitrile-methanol-water (11 : 7 : 35) as mobile phase, and were detected at 225 nm. Ethyl benzoate was used as an internal standard. In six brand of tablets, D0, D1 and D2 were found to be 0.131.84, 0.160.29 and 1.604.19 μg/tab., respectively. 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subjects determination of digoxin hy drolyzed products
digoxin
digoxin tablet
dissolution test of digoxin tablet
HPLC
title Determination of digoxin hydrolyzed products in digoxin tablet and in the medium after dissolution test by HPLC
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