Immunocytochemical and Biochemical Studies of Glutathione-Peroxidase (GSH-PO) in Rat Gastric Parietal Cells
Histamine as an acid secretagogue and H2-blocker (roxatidine acetate hydrochloride) and a proton pump inhibitor (Omeprazole) as acid secretion inhibitors, in single and repeated doses, were administered to investigate associated lipid peroxidation in rat gastric parietal cells. Methods used included...
Gespeichert in:
| Veröffentlicht in: | ACTA HISTOCHEMICA ET CYTOCHEMICA 2002, Vol.35(1), pp.23-31 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 31 |
|---|---|
| container_issue | 1 |
| container_start_page | 23 |
| container_title | ACTA HISTOCHEMICA ET CYTOCHEMICA |
| container_volume | 35 |
| creator | Kimura, Norio Miwa, Takashi |
| description | Histamine as an acid secretagogue and H2-blocker (roxatidine acetate hydrochloride) and a proton pump inhibitor (Omeprazole) as acid secretion inhibitors, in single and repeated doses, were administered to investigate associated lipid peroxidation in rat gastric parietal cells. Methods used included immunohistocytochemical localization and biochemical enzyme activity of glutathione-peroxidase, an enzyme that effectively reduces lipid peroxides. No changes in lipid peroxidation, in response to the H2-blocker, were observed, however its accumulation in the vicinity of vacuole-like structures was specific to proton pump inhibition. This finding suggests that lipid peroxidation occurs in local parietal cells. |
| doi_str_mv | 10.1267/ahc.35.23 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_1448420853</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3117446581</sourcerecordid><originalsourceid>FETCH-LOGICAL-c536t-2f3efb5bad21b8a7c93607dd4d425734419007c9ba41bf66f345f96ea69d74243</originalsourceid><addsrcrecordid>eNpFkE9Lw0AQxRdRsFYPfoMFL3pI3b9JcxG0aFootFg9L5PNxmxNk7q7AfvtTanWywzz5sd78BC6pmREWZzcQ6VHXI4YP0EDykUSyTEhp2hAiBCRTFN6ji68XxNCe10M0Odss-maVu9CqyuzsRpqDE2Bn-z_vQpdYY3HbYmzugsQKts2Jloa137bArzBt9lqGi0Xd9g2-BUCzsAHZzVegrMm9BYTU9f-Ep2VUHtz9buH6P3l-W0yjeaLbDZ5nEda8jhErOSmzGUOBaP5GBKd8pgkRSEKwWTChaApIb2ag6B5GcclF7JMYwNxWiSCCT5ENwffrWu_OuODWreda_pIRYUYC0bGkvfU3YHSrvXemVJtnd2A2ylK1L5L1XepuFRszz4c2LUP8GGOJLhgdW3-SHoYjB8fugKnTMN_AJwwfTc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1448420853</pqid></control><display><type>article</type><title>Immunocytochemical and Biochemical Studies of Glutathione-Peroxidase (GSH-PO) in Rat Gastric Parietal Cells</title><source>J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese</source><source>Open Access Titles of Japan</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Free Full-Text Journals in Chemistry</source><creator>Kimura, Norio ; Miwa, Takashi</creator><creatorcontrib>Kimura, Norio ; Miwa, Takashi</creatorcontrib><description>Histamine as an acid secretagogue and H2-blocker (roxatidine acetate hydrochloride) and a proton pump inhibitor (Omeprazole) as acid secretion inhibitors, in single and repeated doses, were administered to investigate associated lipid peroxidation in rat gastric parietal cells. Methods used included immunohistocytochemical localization and biochemical enzyme activity of glutathione-peroxidase, an enzyme that effectively reduces lipid peroxides. No changes in lipid peroxidation, in response to the H2-blocker, were observed, however its accumulation in the vicinity of vacuole-like structures was specific to proton pump inhibition. This finding suggests that lipid peroxidation occurs in local parietal cells.</description><identifier>ISSN: 0044-5991</identifier><identifier>EISSN: 1347-5800</identifier><identifier>DOI: 10.1267/ahc.35.23</identifier><language>eng</language><publisher>Sendai: JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY</publisher><subject>Glutathione-peroxidase ; Lipid peroxidation ; Omeprazole ; Parietal cell ; Roxatidine acetate hydrochloride</subject><ispartof>ACTA HISTOCHEMICA ET CYTOCHEMICA, 2002, Vol.35(1), pp.23-31</ispartof><rights>2002 By the Japan Society of Histochemistry and Cytochemistry</rights><rights>Copyright Japan Science and Technology Agency 2002</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c536t-2f3efb5bad21b8a7c93607dd4d425734419007c9ba41bf66f345f96ea69d74243</citedby><cites>FETCH-LOGICAL-c536t-2f3efb5bad21b8a7c93607dd4d425734419007c9ba41bf66f345f96ea69d74243</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,27924,27925</link.rule.ids></links><search><creatorcontrib>Kimura, Norio</creatorcontrib><creatorcontrib>Miwa, Takashi</creatorcontrib><title>Immunocytochemical and Biochemical Studies of Glutathione-Peroxidase (GSH-PO) in Rat Gastric Parietal Cells</title><title>ACTA HISTOCHEMICA ET CYTOCHEMICA</title><addtitle>Acta Histochem. Cytochem.</addtitle><description>Histamine as an acid secretagogue and H2-blocker (roxatidine acetate hydrochloride) and a proton pump inhibitor (Omeprazole) as acid secretion inhibitors, in single and repeated doses, were administered to investigate associated lipid peroxidation in rat gastric parietal cells. Methods used included immunohistocytochemical localization and biochemical enzyme activity of glutathione-peroxidase, an enzyme that effectively reduces lipid peroxides. No changes in lipid peroxidation, in response to the H2-blocker, were observed, however its accumulation in the vicinity of vacuole-like structures was specific to proton pump inhibition. This finding suggests that lipid peroxidation occurs in local parietal cells.</description><subject>Glutathione-peroxidase</subject><subject>Lipid peroxidation</subject><subject>Omeprazole</subject><subject>Parietal cell</subject><subject>Roxatidine acetate hydrochloride</subject><issn>0044-5991</issn><issn>1347-5800</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><recordid>eNpFkE9Lw0AQxRdRsFYPfoMFL3pI3b9JcxG0aFootFg9L5PNxmxNk7q7AfvtTanWywzz5sd78BC6pmREWZzcQ6VHXI4YP0EDykUSyTEhp2hAiBCRTFN6ji68XxNCe10M0Odss-maVu9CqyuzsRpqDE2Bn-z_vQpdYY3HbYmzugsQKts2Jloa137bArzBt9lqGi0Xd9g2-BUCzsAHZzVegrMm9BYTU9f-Ep2VUHtz9buH6P3l-W0yjeaLbDZ5nEda8jhErOSmzGUOBaP5GBKd8pgkRSEKwWTChaApIb2ag6B5GcclF7JMYwNxWiSCCT5ENwffrWu_OuODWreda_pIRYUYC0bGkvfU3YHSrvXemVJtnd2A2ylK1L5L1XepuFRszz4c2LUP8GGOJLhgdW3-SHoYjB8fugKnTMN_AJwwfTc</recordid><startdate>20020101</startdate><enddate>20020101</enddate><creator>Kimura, Norio</creator><creator>Miwa, Takashi</creator><general>JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY</general><general>Japan Science and Technology Agency</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20020101</creationdate><title>Immunocytochemical and Biochemical Studies of Glutathione-Peroxidase (GSH-PO) in Rat Gastric Parietal Cells</title><author>Kimura, Norio ; Miwa, Takashi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c536t-2f3efb5bad21b8a7c93607dd4d425734419007c9ba41bf66f345f96ea69d74243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Glutathione-peroxidase</topic><topic>Lipid peroxidation</topic><topic>Omeprazole</topic><topic>Parietal cell</topic><topic>Roxatidine acetate hydrochloride</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kimura, Norio</creatorcontrib><creatorcontrib>Miwa, Takashi</creatorcontrib><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>ACTA HISTOCHEMICA ET CYTOCHEMICA</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kimura, Norio</au><au>Miwa, Takashi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunocytochemical and Biochemical Studies of Glutathione-Peroxidase (GSH-PO) in Rat Gastric Parietal Cells</atitle><jtitle>ACTA HISTOCHEMICA ET CYTOCHEMICA</jtitle><addtitle>Acta Histochem. Cytochem.</addtitle><date>2002-01-01</date><risdate>2002</risdate><volume>35</volume><issue>1</issue><spage>23</spage><epage>31</epage><pages>23-31</pages><issn>0044-5991</issn><eissn>1347-5800</eissn><abstract>Histamine as an acid secretagogue and H2-blocker (roxatidine acetate hydrochloride) and a proton pump inhibitor (Omeprazole) as acid secretion inhibitors, in single and repeated doses, were administered to investigate associated lipid peroxidation in rat gastric parietal cells. Methods used included immunohistocytochemical localization and biochemical enzyme activity of glutathione-peroxidase, an enzyme that effectively reduces lipid peroxides. No changes in lipid peroxidation, in response to the H2-blocker, were observed, however its accumulation in the vicinity of vacuole-like structures was specific to proton pump inhibition. This finding suggests that lipid peroxidation occurs in local parietal cells.</abstract><cop>Sendai</cop><pub>JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY</pub><doi>10.1267/ahc.35.23</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0044-5991 |
| ispartof | ACTA HISTOCHEMICA ET CYTOCHEMICA, 2002, Vol.35(1), pp.23-31 |
| issn | 0044-5991 1347-5800 |
| language | eng |
| recordid | cdi_proquest_journals_1448420853 |
| source | J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; Open Access Titles of Japan; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | Glutathione-peroxidase Lipid peroxidation Omeprazole Parietal cell Roxatidine acetate hydrochloride |
| title | Immunocytochemical and Biochemical Studies of Glutathione-Peroxidase (GSH-PO) in Rat Gastric Parietal Cells |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T08%3A55%3A20IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Immunocytochemical%20and%20Biochemical%20Studies%20of%20Glutathione-Peroxidase%20(GSH-PO)%20in%20Rat%20Gastric%20Parietal%20Cells&rft.jtitle=ACTA%20HISTOCHEMICA%20ET%20CYTOCHEMICA&rft.au=Kimura,%20Norio&rft.date=2002-01-01&rft.volume=35&rft.issue=1&rft.spage=23&rft.epage=31&rft.pages=23-31&rft.issn=0044-5991&rft.eissn=1347-5800&rft_id=info:doi/10.1267/ahc.35.23&rft_dat=%3Cproquest_cross%3E3117446581%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1448420853&rft_id=info:pmid/&rfr_iscdi=true |