Study of Surface-Assisted Laser Desorption/Ionization Mass Spectrometry Using Metal Sulfide Particles as a Matrix

Metal sulfide compounds have unique properties and are widely used in various applications. In this study, we investigated the efficacy of metal sulfide particles as matrices for the ionization of synthetic polymers, by surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS). After the preparation of metal sulfide particles (NiS, CuS, and ZnS) using a shaker, the dispersed solutions of matrix and analytes were spotted on an LDI plate and measured using a 337 nm nitrogen laser. Among the particles studied, NiS particles were the most efficient matrix for SALDI-MS.