Basic Studies on Quantitative Determination of Two Glucuronides of Befunolol Metabolite by Selected Ion Monitoring(SIM)Using Mono-deuterium Labelled Compound
Selected ion monitoring has heen developed for the determination of two glucuronides detected in human urine after oral administration of befunolol(BF). It was confirmed that not only multi-deuterium labelled compound(I-d6)but also mono-deuterium labelled one(I-d1)were useful internal standard at de...
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| Veröffentlicht in: | Journal of the Mass Spectrometry Society of Japan 1978/12/30, Vol.26(4), pp.343-352 |
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| container_title | Journal of the Mass Spectrometry Society of Japan |
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| creator | Tohno, Masao Matsumura, Yuzuru Ofuji, Tatsuya Tatematsu, Akira Suzuki, Makoto Yoshizumi, Hideo Harada, Kenichi Nadai, Tanekazu |
| description | Selected ion monitoring has heen developed for the determination of two glucuronides detected in human urine after oral administration of befunolol(BF). It was confirmed that not only multi-deuterium labelled compound(I-d6)but also mono-deuterium labelled one(I-d1)were useful internal standard at determination of the common aglycone, 2-(1-hydroxyethyl)-7-(2-hydroxy-3-isopropylaminopropoxy)benzofuran of these glucuronides. The glucuronides had been identified as O-glucuronide of side-chain of I(II)and O-glucuronide of 2-side-chain of I(III). Each glucuronide was determined by the combination of enzymatic hydrolysis, thin layer chromatography and selected ion monitoring using II-d1 as internal standard. The overall recoveries(%)of II and III were 101.3±1.9(SE)and 101.1±1.4(SE)respectively. Over 70% of dose determined as I, II and III in the urine of man received BF 15-20 mg orally. It can therefore be presumed that major metabolic pathway of BF in man is the reduction followed by the glucuronidation. |
| doi_str_mv | 10.5702/massspec1953.26.343 |
| format | Article |
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It was confirmed that not only multi-deuterium labelled compound(I-d6)but also mono-deuterium labelled one(I-d1)were useful internal standard at determination of the common aglycone, 2-(1-hydroxyethyl)-7-(2-hydroxy-3-isopropylaminopropoxy)benzofuran of these glucuronides. The glucuronides had been identified as O-glucuronide of side-chain of I(II)and O-glucuronide of 2-side-chain of I(III). Each glucuronide was determined by the combination of enzymatic hydrolysis, thin layer chromatography and selected ion monitoring using II-d1 as internal standard. The overall recoveries(%)of II and III were 101.3±1.9(SE)and 101.1±1.4(SE)respectively. Over 70% of dose determined as I, II and III in the urine of man received BF 15-20 mg orally. It can therefore be presumed that major metabolic pathway of BF in man is the reduction followed by the glucuronidation.</description><identifier>ISSN: 1340-8097</identifier><identifier>EISSN: 1880-4225</identifier><identifier>EISSN: 1884-3271</identifier><identifier>DOI: 10.5702/massspec1953.26.343</identifier><language>eng</language><publisher>Tokyo: The Mass Spectrometry Society of Japan</publisher><subject>Befunolol metabolism ; GC-MS ; Glucurollide ; Mono-deuterated glucuronide ; Quantitative analysis ; Selcted ion monitoring ; β-Blocking agent</subject><ispartof>Journal of the Mass Spectrometry Society of Japan, 1978/12/30, Vol.26(4), pp.343-352</ispartof><rights>The Mass Spectrometry Society of Japan</rights><rights>Copyright Japan Science and Technology Agency 1978</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2323-7660c21ba06d9056fa743297de9cca5df153ec0946cab3beca77343972f3007b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1881,27923,27924</link.rule.ids></links><search><creatorcontrib>Tohno, Masao</creatorcontrib><creatorcontrib>Matsumura, Yuzuru</creatorcontrib><creatorcontrib>Ofuji, Tatsuya</creatorcontrib><creatorcontrib>Tatematsu, Akira</creatorcontrib><creatorcontrib>Suzuki, Makoto</creatorcontrib><creatorcontrib>Yoshizumi, Hideo</creatorcontrib><creatorcontrib>Harada, Kenichi</creatorcontrib><creatorcontrib>Nadai, Tanekazu</creatorcontrib><title>Basic Studies on Quantitative Determination of Two Glucuronides of Befunolol Metabolite by Selected Ion Monitoring(SIM)Using Mono-deuterium Labelled Compound</title><title>Journal of the Mass Spectrometry Society of Japan</title><addtitle>J. Mass Spectrom. Soc. Jpn.</addtitle><description>Selected ion monitoring has heen developed for the determination of two glucuronides detected in human urine after oral administration of befunolol(BF). It was confirmed that not only multi-deuterium labelled compound(I-d6)but also mono-deuterium labelled one(I-d1)were useful internal standard at determination of the common aglycone, 2-(1-hydroxyethyl)-7-(2-hydroxy-3-isopropylaminopropoxy)benzofuran of these glucuronides. The glucuronides had been identified as O-glucuronide of side-chain of I(II)and O-glucuronide of 2-side-chain of I(III). Each glucuronide was determined by the combination of enzymatic hydrolysis, thin layer chromatography and selected ion monitoring using II-d1 as internal standard. The overall recoveries(%)of II and III were 101.3±1.9(SE)and 101.1±1.4(SE)respectively. Over 70% of dose determined as I, II and III in the urine of man received BF 15-20 mg orally. It can therefore be presumed that major metabolic pathway of BF in man is the reduction followed by the glucuronidation.</description><subject>Befunolol metabolism</subject><subject>GC-MS</subject><subject>Glucurollide</subject><subject>Mono-deuterated glucuronide</subject><subject>Quantitative analysis</subject><subject>Selcted ion monitoring</subject><subject>β-Blocking agent</subject><issn>1340-8097</issn><issn>1880-4225</issn><issn>1884-3271</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><recordid>eNplkc1uEzEUhUeISpSWJ2BjiQ0sJnhsjx0vaQptpERVlXZteTx3iiOPHfwD6sPwrjgKqpDY2Ofa57tHurdp3nd40QtMPs86pXQA08meLghfUEZfNefdcolbRkj_umrKcLvEUrxp3qa0x5gRLsR58_tKJ2vQLpfRQkLBo_uifbZZZ_sT0DVkiLP1tapfYUIPvwK6ccWUGLwdj8SErmAqPrjg0BayHoKzGdDwjHbgwGQY0bqy2-rPIVr_9HG33n56TFUdH0M7QqkhtsxoowdwrgKrMB9C8eNlczZpl-Dd3_uiefz29WF1227ubtarL5vWEEpoKzjHhnSDxnyUuOeTFowSKUaQxuh-nLqegsGScaMHOoDRQtQRSUEmirEY6EXz4dT3EMOPAimrfSjR10jVMcYlwUyS6qInl4khpQiTOkQ76_isOqyOe1D_7kERrmpIpW5P1D5l_QQvjI7ZGgf_Mex0VPTFYr7rqMDTP0-RmoQ</recordid><startdate>19781230</startdate><enddate>19781230</enddate><creator>Tohno, Masao</creator><creator>Matsumura, Yuzuru</creator><creator>Ofuji, Tatsuya</creator><creator>Tatematsu, Akira</creator><creator>Suzuki, Makoto</creator><creator>Yoshizumi, Hideo</creator><creator>Harada, Kenichi</creator><creator>Nadai, Tanekazu</creator><general>The Mass Spectrometry Society of Japan</general><general>Japan Science and Technology Agency</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope></search><sort><creationdate>19781230</creationdate><title>Basic Studies on Quantitative Determination of Two Glucuronides of Befunolol Metabolite by Selected Ion Monitoring(SIM)Using Mono-deuterium Labelled Compound</title><author>Tohno, Masao ; Matsumura, Yuzuru ; Ofuji, Tatsuya ; Tatematsu, Akira ; Suzuki, Makoto ; Yoshizumi, Hideo ; Harada, Kenichi ; Nadai, Tanekazu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2323-7660c21ba06d9056fa743297de9cca5df153ec0946cab3beca77343972f3007b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1978</creationdate><topic>Befunolol metabolism</topic><topic>GC-MS</topic><topic>Glucurollide</topic><topic>Mono-deuterated glucuronide</topic><topic>Quantitative analysis</topic><topic>Selcted ion monitoring</topic><topic>β-Blocking agent</topic><toplevel>online_resources</toplevel><creatorcontrib>Tohno, Masao</creatorcontrib><creatorcontrib>Matsumura, Yuzuru</creatorcontrib><creatorcontrib>Ofuji, Tatsuya</creatorcontrib><creatorcontrib>Tatematsu, Akira</creatorcontrib><creatorcontrib>Suzuki, Makoto</creatorcontrib><creatorcontrib>Yoshizumi, Hideo</creatorcontrib><creatorcontrib>Harada, Kenichi</creatorcontrib><creatorcontrib>Nadai, Tanekazu</creatorcontrib><collection>CrossRef</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Journal of the Mass Spectrometry Society of Japan</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tohno, Masao</au><au>Matsumura, Yuzuru</au><au>Ofuji, Tatsuya</au><au>Tatematsu, Akira</au><au>Suzuki, Makoto</au><au>Yoshizumi, Hideo</au><au>Harada, Kenichi</au><au>Nadai, Tanekazu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Basic Studies on Quantitative Determination of Two Glucuronides of Befunolol Metabolite by Selected Ion Monitoring(SIM)Using Mono-deuterium Labelled Compound</atitle><jtitle>Journal of the Mass Spectrometry Society of Japan</jtitle><addtitle>J. Mass Spectrom. Soc. Jpn.</addtitle><date>1978-12-30</date><risdate>1978</risdate><volume>26</volume><issue>4</issue><spage>343</spage><epage>352</epage><pages>343-352</pages><issn>1340-8097</issn><eissn>1880-4225</eissn><eissn>1884-3271</eissn><abstract>Selected ion monitoring has heen developed for the determination of two glucuronides detected in human urine after oral administration of befunolol(BF). It was confirmed that not only multi-deuterium labelled compound(I-d6)but also mono-deuterium labelled one(I-d1)were useful internal standard at determination of the common aglycone, 2-(1-hydroxyethyl)-7-(2-hydroxy-3-isopropylaminopropoxy)benzofuran of these glucuronides. The glucuronides had been identified as O-glucuronide of side-chain of I(II)and O-glucuronide of 2-side-chain of I(III). Each glucuronide was determined by the combination of enzymatic hydrolysis, thin layer chromatography and selected ion monitoring using II-d1 as internal standard. The overall recoveries(%)of II and III were 101.3±1.9(SE)and 101.1±1.4(SE)respectively. Over 70% of dose determined as I, II and III in the urine of man received BF 15-20 mg orally. It can therefore be presumed that major metabolic pathway of BF in man is the reduction followed by the glucuronidation.</abstract><cop>Tokyo</cop><pub>The Mass Spectrometry Society of Japan</pub><doi>10.5702/massspec1953.26.343</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| issn | 1340-8097 1880-4225 1884-3271 |
| language | eng |
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| source | J-STAGE Free; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | Befunolol metabolism GC-MS Glucurollide Mono-deuterated glucuronide Quantitative analysis Selcted ion monitoring β-Blocking agent |
| title | Basic Studies on Quantitative Determination of Two Glucuronides of Befunolol Metabolite by Selected Ion Monitoring(SIM)Using Mono-deuterium Labelled Compound |
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