Evaluation of THP-1 cell line as an in vitro model for long-term safety assessment of new molecules

Synopsis Objective Monitoring the chronic and subacute toxicity is essential in the development of new cosmetic ingredients. In response to the present lack of validated alternative methods, we developed an in vitro model for repeated dose cytotoxicity on THP‐1 cells. Methods Cultured in suspension,...

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Veröffentlicht in:	International journal of cosmetic science 2013-12, Vol.35 (6), p.568-574
Hauptverfasser:	Garcia, I., Pouzet, C., Brulas, M., Bauza, E., Botto, J.M., Domloge, N.
Format:	Artikel
Sprache:	eng
Schlagworte:	alternative method cell culture Cell Line, Tumor Cell Survival - drug effects Comet Assay Cytotoxicity Humans in vitro Nitro Compounds - toxicity Paraquat - toxicity Propionates - toxicity safety testing Sodium Dodecyl Sulfate - toxicity subacute cytotoxicity Toxicity Tests - methods
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