Role of ADAM‐17, p38 MAPK, Cathepsins, and the Proteasome Pathway in the Synthesis and Shedding of Fractalkine/CX3CL1 in Rheumatoid Arthritis

Objective To evaluate the mechanism of fractalkine (FKN)/CX3CL1 synthesis and shedding in rheumatoid arthritis synovial fibroblasts (RASFs) and in rat adjuvant‐induced arthritis (AIA). Methods The effect of tumor necrosis factor α (TNFα) and/or interferon‐γ (IFNγ) on FKN synthesis and shedding in hu...

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Veröffentlicht in:	Arthritis & rheumatology (Hoboken, N.J.) N.J.), 2013-11, Vol.65 (11), p.2814-2825
Hauptverfasser:	Jones, Brian A., Riegsecker, Sharayah, Rahman, Ayesha, Beamer, Maria, Aboualaiwi, Wissam, Khuder, Sadik A., Ahmed, Salahuddin
Format:	Artikel
Sprache:	eng
Schlagworte:	Medical research Rheumatoid arthritis
Online-Zugang:	Volltext
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