The BC component of ABC toxins is an RHS-repeat-containing protein encapsulation device

The crystal structure of the complex formed by the B and C toxin complex proteins is reported, revealing how toxin complexes are processed and protected; the proteins assemble to form a large hollow structure that sequesters the cytotoxic portion of the C protein, and a β-propeller domain mediates a...

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Veröffentlicht in:	Nature (London) 2013-09, Vol.501 (7468), p.547-550
Hauptverfasser:	Busby, Jason N., Panjikar, Santosh, Landsberg, Michael J., Hurst, Mark R. H., Lott, J. Shaun
Format:	Artikel
Sprache:	eng
Schlagworte:	631/326/421 631/535/1258 631/535/1261 631/535/1266 Amino Acid Motifs Amino Acid Sequence Bacterial infections Bacterial Toxins - chemistry Bacterial Toxins - metabolism Chromatography Consensus Sequence Conserved Sequence Crystallography Crystallography, X-Ray Cytotoxicity Humanities and Social Sciences Insecticides - chemistry letter Models, Molecular Molecular Sequence Data multidisciplinary Physiological aspects Polypeptides Protein Subunits - chemistry Protein Subunits - metabolism Proteins Proteolysis Repetitive Sequences, Amino Acid Science Toxins Translocation Yersinia - chemistry
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