Retrotransposition of Limited Deletion Type of Intracisternal A-particle Elements in the Myeloid Leukemia Clls of C3H/He Mice
The murine genome has about 1,000 copies of DNA elements for the intracisternal A-particle (IAP) that resembles a retrovirus. We previously reported that the genomic DNA of the cells from radiation-induced acute myeloid leukemia (AML) lines derived from C3H/He inbred mice was frequently rearranged b...
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| Veröffentlicht in: | JOURNAL OF RADIATION RESEARCH 2004, Vol.45 (1), p.25-32 |
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| creator | Ishihara, Hiroshi Tanaka, Izumi Wan, Hong Nojima, Kumie Yoshida, Kazuko |
| description | The murine genome has about 1,000 copies of DNA elements for the intracisternal A-particle (IAP) that resembles a retrovirus. We previously reported that the genomic DNA of the cells from radiation-induced acute myeloid leukemia (AML) lines derived from C3H/He inbred mice was frequently rearranged by the integration of the IAP element. In this study, 8 IAP elements from the characteristic integration sites in 6 cell lines of radiation-induced AML from different mice were characterized and compared in structure with 114 IAP elements isolated from the normal C3H/He genome. One of the 8 elements was a full-length type I IAP, and 7 were of type-IΔ1 with a common deletion site. Although the type IΔ1 form is a minor population accounting for about 6% of total genomic IAP elements, it is predominantly retrotransposed in the AML cells from different C3H/He mice. This indicates that limited populations of the IAP elements contribute to the unique retrotransposition in AML cells. |
| doi_str_mv | 10.1269/jrr.45.25 |
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We previously reported that the genomic DNA of the cells from radiation-induced acute myeloid leukemia (AML) lines derived from C3H/He inbred mice was frequently rearranged by the integration of the IAP element. In this study, 8 IAP elements from the characteristic integration sites in 6 cell lines of radiation-induced AML from different mice were characterized and compared in structure with 114 IAP elements isolated from the normal C3H/He genome. One of the 8 elements was a full-length type I IAP, and 7 were of type-IΔ1 with a common deletion site. Although the type IΔ1 form is a minor population accounting for about 6% of total genomic IAP elements, it is predominantly retrotransposed in the AML cells from different C3H/He mice. This indicates that limited populations of the IAP elements contribute to the unique retrotransposition in AML cells.</description><identifier>ISSN: 0449-3060</identifier><identifier>EISSN: 1349-9157</identifier><identifier>DOI: 10.1269/jrr.45.25</identifier><identifier>PMID: 15133286</identifier><language>eng</language><publisher>England: THE JAPAN RADIATION RESEARCH SOCIETY</publisher><subject>Animals ; Base Sequence ; Cell Line, Tumor ; Gene Deletion ; Gene Expression Regulation, Neoplastic - radiation effects ; Genes, Intracisternal A-Particle - genetics ; Genes, Intracisternal A-Particle - radiation effects ; Genetic Variation ; Leukemia, Myeloid, Acute - genetics ; Leukemia, Radiation-Induced - genetics ; Mice ; Mice, Inbred C3H ; Molecular Sequence Data ; Phenotype ; Retroelements - genetics ; Sequence Analysis, DNA - methods ; Sequence Homology, Nucleic Acid</subject><ispartof>JOURNAL OF RADIATION RESEARCH, 2004, Vol.45 (1), p.25-32</ispartof><rights>Copyright Japan Science and Technology Agency 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c509t-402e0d10a3d9d46cd3d35833d4fa2f4142a0830262e9e35f9055dd84d780803e3</citedby><cites>FETCH-LOGICAL-c509t-402e0d10a3d9d46cd3d35833d4fa2f4142a0830262e9e35f9055dd84d780803e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,4009,27901,27902,27903</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15133286$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ishihara, Hiroshi</creatorcontrib><creatorcontrib>Tanaka, Izumi</creatorcontrib><creatorcontrib>Wan, Hong</creatorcontrib><creatorcontrib>Nojima, Kumie</creatorcontrib><creatorcontrib>Yoshida, Kazuko</creatorcontrib><creatorcontrib>Redox Regulation Research Group</creatorcontrib><creatorcontrib>National Institute of Radiological Sciences</creatorcontrib><creatorcontrib>Radiation Hazard Research Group</creatorcontrib><creatorcontrib>International Space Radiation Laboratory</creatorcontrib><creatorcontrib>Radiation Safety Research Center</creatorcontrib><title>Retrotransposition of Limited Deletion Type of Intracisternal A-particle Elements in the Myeloid Leukemia Clls of C3H/He Mice</title><title>JOURNAL OF RADIATION RESEARCH</title><addtitle>J Radiat Res</addtitle><description>The murine genome has about 1,000 copies of DNA elements for the intracisternal A-particle (IAP) that resembles a retrovirus. We previously reported that the genomic DNA of the cells from radiation-induced acute myeloid leukemia (AML) lines derived from C3H/He inbred mice was frequently rearranged by the integration of the IAP element. In this study, 8 IAP elements from the characteristic integration sites in 6 cell lines of radiation-induced AML from different mice were characterized and compared in structure with 114 IAP elements isolated from the normal C3H/He genome. One of the 8 elements was a full-length type I IAP, and 7 were of type-IΔ1 with a common deletion site. Although the type IΔ1 form is a minor population accounting for about 6% of total genomic IAP elements, it is predominantly retrotransposed in the AML cells from different C3H/He mice. This indicates that limited populations of the IAP elements contribute to the unique retrotransposition in AML cells.</description><subject>Animals</subject><subject>Base Sequence</subject><subject>Cell Line, Tumor</subject><subject>Gene Deletion</subject><subject>Gene Expression Regulation, Neoplastic - radiation effects</subject><subject>Genes, Intracisternal A-Particle - genetics</subject><subject>Genes, Intracisternal A-Particle - radiation effects</subject><subject>Genetic Variation</subject><subject>Leukemia, Myeloid, Acute - genetics</subject><subject>Leukemia, Radiation-Induced - genetics</subject><subject>Mice</subject><subject>Mice, Inbred C3H</subject><subject>Molecular Sequence Data</subject><subject>Phenotype</subject><subject>Retroelements - genetics</subject><subject>Sequence Analysis, DNA - methods</subject><subject>Sequence Homology, Nucleic Acid</subject><issn>0449-3060</issn><issn>1349-9157</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEFrGzEQhUVpaUyaQ_9AEfTUwzojjbTePQY3jQMuhZKehbKapXLk1VaSDz70v1euDTmMZtD7eMM8xj4KWArZ9re7lJZKL6V-wxYCVd_0Qq_esgWoOiO0cMVucvbPIHQL0Anxnl0JLRBl1y7Y359UUizJTnmO2RcfJx5HvvV7X8jxrxTo_9_TcaaT8DhVdvC5UJps4HfNbFPxQyB-H2hPU8ncT7z8Jv79SCF6x7d0eKG9t3wdQj5ZrHFzu6m6H-gDezfakOnm0q_Zr2_3T-tNs_3x8Li-2zaDhr40CiSBE2DR9U61g0OHukN0arRyVEJJCx2CbCX1hHrsQWvnOuVWHXSAhNfs89l3TvHPgXIxu3g4HZCNUDUnXKFuK_XlTA0p5pxoNHPye5uORoA5ZW1q1kZpI3VlP10cD897cq_kJdkKPJyBqvrBhjgFP9Hr3uGl3cWUyEgAZWppEOY8Sl0flALq3SvAf7Hrjzk</recordid><startdate>2004</startdate><enddate>2004</enddate><creator>Ishihara, Hiroshi</creator><creator>Tanaka, Izumi</creator><creator>Wan, Hong</creator><creator>Nojima, Kumie</creator><creator>Yoshida, Kazuko</creator><general>THE JAPAN RADIATION RESEARCH SOCIETY</general><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope></search><sort><creationdate>2004</creationdate><title>Retrotransposition of Limited Deletion Type of Intracisternal A-particle Elements in the Myeloid Leukemia Clls of C3H/He Mice</title><author>Ishihara, Hiroshi ; Tanaka, Izumi ; Wan, Hong ; Nojima, Kumie ; Yoshida, Kazuko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c509t-402e0d10a3d9d46cd3d35833d4fa2f4142a0830262e9e35f9055dd84d780803e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Base Sequence</topic><topic>Cell Line, Tumor</topic><topic>Gene Deletion</topic><topic>Gene Expression Regulation, Neoplastic - radiation effects</topic><topic>Genes, Intracisternal A-Particle - genetics</topic><topic>Genes, Intracisternal A-Particle - radiation effects</topic><topic>Genetic Variation</topic><topic>Leukemia, Myeloid, Acute - genetics</topic><topic>Leukemia, Radiation-Induced - genetics</topic><topic>Mice</topic><topic>Mice, Inbred C3H</topic><topic>Molecular Sequence Data</topic><topic>Phenotype</topic><topic>Retroelements - genetics</topic><topic>Sequence Analysis, DNA - methods</topic><topic>Sequence Homology, Nucleic Acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ishihara, Hiroshi</creatorcontrib><creatorcontrib>Tanaka, Izumi</creatorcontrib><creatorcontrib>Wan, Hong</creatorcontrib><creatorcontrib>Nojima, Kumie</creatorcontrib><creatorcontrib>Yoshida, Kazuko</creatorcontrib><creatorcontrib>Redox Regulation Research Group</creatorcontrib><creatorcontrib>National Institute of Radiological Sciences</creatorcontrib><creatorcontrib>Radiation Hazard Research Group</creatorcontrib><creatorcontrib>International Space Radiation Laboratory</creatorcontrib><creatorcontrib>Radiation Safety Research Center</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>JOURNAL OF RADIATION RESEARCH</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ishihara, Hiroshi</au><au>Tanaka, Izumi</au><au>Wan, Hong</au><au>Nojima, Kumie</au><au>Yoshida, Kazuko</au><aucorp>Redox Regulation Research Group</aucorp><aucorp>National Institute of Radiological Sciences</aucorp><aucorp>Radiation Hazard Research Group</aucorp><aucorp>International Space Radiation Laboratory</aucorp><aucorp>Radiation Safety Research Center</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Retrotransposition of Limited Deletion Type of Intracisternal A-particle Elements in the Myeloid Leukemia Clls of C3H/He Mice</atitle><jtitle>JOURNAL OF RADIATION RESEARCH</jtitle><addtitle>J Radiat Res</addtitle><date>2004</date><risdate>2004</risdate><volume>45</volume><issue>1</issue><spage>25</spage><epage>32</epage><pages>25-32</pages><issn>0449-3060</issn><eissn>1349-9157</eissn><abstract>The murine genome has about 1,000 copies of DNA elements for the intracisternal A-particle (IAP) that resembles a retrovirus. We previously reported that the genomic DNA of the cells from radiation-induced acute myeloid leukemia (AML) lines derived from C3H/He inbred mice was frequently rearranged by the integration of the IAP element. In this study, 8 IAP elements from the characteristic integration sites in 6 cell lines of radiation-induced AML from different mice were characterized and compared in structure with 114 IAP elements isolated from the normal C3H/He genome. One of the 8 elements was a full-length type I IAP, and 7 were of type-IΔ1 with a common deletion site. Although the type IΔ1 form is a minor population accounting for about 6% of total genomic IAP elements, it is predominantly retrotransposed in the AML cells from different C3H/He mice. This indicates that limited populations of the IAP elements contribute to the unique retrotransposition in AML cells.</abstract><cop>England</cop><pub>THE JAPAN RADIATION RESEARCH SOCIETY</pub><pmid>15133286</pmid><doi>10.1269/jrr.45.25</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Base Sequence Cell Line, Tumor Gene Deletion Gene Expression Regulation, Neoplastic - radiation effects Genes, Intracisternal A-Particle - genetics Genes, Intracisternal A-Particle - radiation effects Genetic Variation Leukemia, Myeloid, Acute - genetics Leukemia, Radiation-Induced - genetics Mice Mice, Inbred C3H Molecular Sequence Data Phenotype Retroelements - genetics Sequence Analysis, DNA - methods Sequence Homology, Nucleic Acid |
| title | Retrotransposition of Limited Deletion Type of Intracisternal A-particle Elements in the Myeloid Leukemia Clls of C3H/He Mice |
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