Chromosome Aberration Analysis in Persons Exposed to Low-level Radiation from the JCO Criticality Accident in Tokai-mura
Chromosome aberrations were studied in peripheral blood lymphocytes of 43 persons who were exposed to low-level radiation of mixed neutrons and γ-rays resulting from the JCO criticality accident. When the age-adjusted frequencies of dicentric and ring chromosomes were compared with the dose calibrat...
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| Veröffentlicht in: | JOURNAL OF RADIATION RESEARCH 2001, Vol.42 (suppl), p.107-116 |
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| container_end_page | 116 |
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| container_issue | suppl |
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| container_title | JOURNAL OF RADIATION RESEARCH |
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| creator | Sasaki, M S Hayata, I Kamada, N Kodama, Y Kodama, S |
| description | Chromosome aberrations were studied in peripheral blood lymphocytes of 43 persons who were exposed to low-level radiation of mixed neutrons and γ-rays resulting from the JCO criticality accident. When the age-adjusted frequencies of dicentric and ring chromosomes were compared with the dose calibration curve established in vitro for ^^60 Co γ-rays as a reference radiation, a significant correlation was observed between the chromosomally estimated doses and the documented doses evaluated by physical means. The regression coefficient of the chromosomal doses against the documented doses, 1.47 ± 0.33, indicates that the relative biological effectiveness of fission neutrons at low doses is considerably higher than that currently adopted in the radiation protection standard. |
| doi_str_mv | 10.1269/jrr.42.S107 |
| format | Article |
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When the age-adjusted frequencies of dicentric and ring chromosomes were compared with the dose calibration curve established in vitro for ^^60 Co γ-rays as a reference radiation, a significant correlation was observed between the chromosomally estimated doses and the documented doses evaluated by physical means. 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When the age-adjusted frequencies of dicentric and ring chromosomes were compared with the dose calibration curve established in vitro for ^^60 Co γ-rays as a reference radiation, a significant correlation was observed between the chromosomally estimated doses and the documented doses evaluated by physical means. The regression coefficient of the chromosomal doses against the documented doses, 1.47 ± 0.33, indicates that the relative biological effectiveness of fission neutrons at low doses is considerably higher than that currently adopted in the radiation protection standard.</description><subject>Adult</subject><subject>Aged</subject><subject>Analysis</subject><subject>Chromosome Aberrations - radiation effects</subject><subject>Dose-Response Relationship, Radiation</subject><subject>Fast Neutrons - adverse effects</subject><subject>Genetic research</subject><subject>Humans</subject><subject>Japan</subject><subject>Lymphocytes - radiation effects</subject><subject>Lymphocytes - ultrastructure</subject><subject>Middle Aged</subject><subject>Radiation (Physics)</subject><subject>Radiation Dosage</subject><subject>Radiation Injuries - genetics</subject><subject>Radioactive Hazard Release</subject><subject>Relative Biological Effectiveness</subject><issn>0449-3060</issn><issn>1349-9157</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkU1r3DAQhk1paZY0p96LoMfircbWh3VcTNImLKS06VnI8qjRxra2kjfN_vtq8UIQ0gjpeUejeYviI9A1VEJ93cW4ZtX6F1D5plhBzVSpgMu3xYqyvK-poBfFVUq-o8AFpQ3A--ICQCqQrF4VL-1jDGNIYUSy6TBGM_swkc1khmPyifiJ_MCYwpTI9cs-JOzJHMg2_CsHfMaB_DS9XyQu5yHzI5K79p600c_emsHPR7Kx1vc4zadcD-HJ-HI8RPOheOfMkPDqHC-L3zfXD-33cnv_7bbdbEvLpZAll5Z10nIOlXFC1o1peuV6I5qm6pApx1XTuJ4awWTXCQaWGeVkg6CQK3D1ZfF5ybuP4e8B06x34RDz95IGlltUSSaqTK0X6o8ZUPvJhTkam0ePo7dhQufz-YbXAjhjlGbBl0VgY0gpotP76EcTjxqoPjmjszOaVfrkTKY_nYs4dCP2r-zZhwzcLEC-PfUtTIOf8LVU-yR2IUbUFaWgKWVVyiE_lafMCwioqapF_R-LXp-O</recordid><startdate>2001</startdate><enddate>2001</enddate><creator>Sasaki, M S</creator><creator>Hayata, I</creator><creator>Kamada, N</creator><creator>Kodama, Y</creator><creator>Kodama, S</creator><general>THE JAPAN RADIATION RESEARCH SOCIETY</general><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope></search><sort><creationdate>2001</creationdate><title>Chromosome Aberration Analysis in Persons Exposed to Low-level Radiation from the JCO Criticality Accident in Tokai-mura</title><author>Sasaki, M S ; Hayata, I ; Kamada, N ; Kodama, Y ; Kodama, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5767-57c4b7c5512af6738a8d9fda6882be49f5988fd0a647bb641c4a9f78e19e591f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Analysis</topic><topic>Chromosome Aberrations - radiation effects</topic><topic>Dose-Response Relationship, Radiation</topic><topic>Fast Neutrons - adverse effects</topic><topic>Genetic research</topic><topic>Humans</topic><topic>Japan</topic><topic>Lymphocytes - radiation effects</topic><topic>Lymphocytes - ultrastructure</topic><topic>Middle Aged</topic><topic>Radiation (Physics)</topic><topic>Radiation Dosage</topic><topic>Radiation Injuries - genetics</topic><topic>Radioactive Hazard Release</topic><topic>Relative Biological Effectiveness</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sasaki, M S</creatorcontrib><creatorcontrib>Hayata, I</creatorcontrib><creatorcontrib>Kamada, N</creatorcontrib><creatorcontrib>Kodama, Y</creatorcontrib><creatorcontrib>Kodama, S</creatorcontrib><creatorcontrib>School of Pharmaceutical Sciences</creatorcontrib><creatorcontrib>National Institute of Radiological Sciences</creatorcontrib><creatorcontrib>Kyoto University</creatorcontrib><creatorcontrib>Radiation Effects Research Foundation</creatorcontrib><creatorcontrib>Radiation Biology Center</creatorcontrib><creatorcontrib>Nagasaki University</creatorcontrib><creatorcontrib>Institute of Radiation Biology and Medicine</creatorcontrib><creatorcontrib>Hiroshima University</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>JOURNAL OF RADIATION RESEARCH</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sasaki, M S</au><au>Hayata, I</au><au>Kamada, N</au><au>Kodama, Y</au><au>Kodama, S</au><aucorp>School of Pharmaceutical Sciences</aucorp><aucorp>National Institute of Radiological Sciences</aucorp><aucorp>Kyoto University</aucorp><aucorp>Radiation Effects Research Foundation</aucorp><aucorp>Radiation Biology Center</aucorp><aucorp>Nagasaki University</aucorp><aucorp>Institute of Radiation Biology and Medicine</aucorp><aucorp>Hiroshima University</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chromosome Aberration Analysis in Persons Exposed to Low-level Radiation from the JCO Criticality Accident in Tokai-mura</atitle><jtitle>JOURNAL OF RADIATION RESEARCH</jtitle><addtitle>J Radiat Res</addtitle><date>2001</date><risdate>2001</risdate><volume>42</volume><issue>suppl</issue><spage>107</spage><epage>116</epage><pages>107-116</pages><issn>0449-3060</issn><eissn>1349-9157</eissn><abstract>Chromosome aberrations were studied in peripheral blood lymphocytes of 43 persons who were exposed to low-level radiation of mixed neutrons and γ-rays resulting from the JCO criticality accident. When the age-adjusted frequencies of dicentric and ring chromosomes were compared with the dose calibration curve established in vitro for ^^60 Co γ-rays as a reference radiation, a significant correlation was observed between the chromosomally estimated doses and the documented doses evaluated by physical means. The regression coefficient of the chromosomal doses against the documented doses, 1.47 ± 0.33, indicates that the relative biological effectiveness of fission neutrons at low doses is considerably higher than that currently adopted in the radiation protection standard.</abstract><cop>England</cop><pub>THE JAPAN RADIATION RESEARCH SOCIETY</pub><pmid>11791743</pmid><doi>10.1269/jrr.42.S107</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| source | Freely Accessible Japanese Titles (ERDB Project); J-STAGE (Free - Japanese); MEDLINE; DOAJ Directory of Open Access Journals; Free Full-Text Journals in Chemistry; EZB Electronic Journals Library; Oxford Open Access Journals |
| subjects | Adult Aged Analysis Chromosome Aberrations - radiation effects Dose-Response Relationship, Radiation Fast Neutrons - adverse effects Genetic research Humans Japan Lymphocytes - radiation effects Lymphocytes - ultrastructure Middle Aged Radiation (Physics) Radiation Dosage Radiation Injuries - genetics Radioactive Hazard Release Relative Biological Effectiveness |
| title | Chromosome Aberration Analysis in Persons Exposed to Low-level Radiation from the JCO Criticality Accident in Tokai-mura |
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