Gallbladder cancer
Abstract Background Gallbladder cancer (GC) is a relatively rare but highly lethal neoplasm. We review the epidemiology, etiology, pathology, symptoms, diagnosis, staging, treatment, and prognosis of GC. Method A Pubmed database search between 1971 and February 2007 was performed. All abstracts were...
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| Veröffentlicht in: | The American journal of surgery 2008-08, Vol.196 (2), p.252-264 |
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| creator | Gourgiotis, Stavros, M.D., Ph.D Kocher, Hemant M., M.D., F.R.C.S Solaini, Leonardo, M.D Yarollahi, Arvin, M.D Tsiambas, Evangelos, M.D Salemis, Nikolaos S., M.D., Ph.D |
| description | Abstract Background Gallbladder cancer (GC) is a relatively rare but highly lethal neoplasm. We review the epidemiology, etiology, pathology, symptoms, diagnosis, staging, treatment, and prognosis of GC. Method A Pubmed database search between 1971 and February 2007 was performed. All abstracts were reviewed and articles with GC obtained; further references were extracted by hand-searching the bibliography. The database search was done in the English language. Results The accurate etiology of GC remains unclear, while the symptoms associated with primary GC are not specific. Treatment with radical cholecystectomy is curative but possible in only 10% to 30% of patients. For patients whose cancer is an incidental finding on pathologic review, re-resection is indicated, where feasible, for all disease except T1a. Patients with advanced disease should receive palliative treatment. Laparoscopic cholecystectomy is contraindicated in the presence of GC. Conclusion Prognosis generally is extremely poor. Improvements in the outcome of surgical resection have caused this approach to be re-evaluated, while the role of chemotherapy and radiotherapy remains controversial. |
| doi_str_mv | 10.1016/j.amjsurg.2007.11.011 |
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We review the epidemiology, etiology, pathology, symptoms, diagnosis, staging, treatment, and prognosis of GC. Method A Pubmed database search between 1971 and February 2007 was performed. All abstracts were reviewed and articles with GC obtained; further references were extracted by hand-searching the bibliography. The database search was done in the English language. Results The accurate etiology of GC remains unclear, while the symptoms associated with primary GC are not specific. Treatment with radical cholecystectomy is curative but possible in only 10% to 30% of patients. For patients whose cancer is an incidental finding on pathologic review, re-resection is indicated, where feasible, for all disease except T1a. Patients with advanced disease should receive palliative treatment. Laparoscopic cholecystectomy is contraindicated in the presence of GC. Conclusion Prognosis generally is extremely poor. Improvements in the outcome of surgical resection have caused this approach to be re-evaluated, while the role of chemotherapy and radiotherapy remains controversial.</description><identifier>ISSN: 0002-9610</identifier><identifier>EISSN: 1879-1883</identifier><identifier>DOI: 10.1016/j.amjsurg.2007.11.011</identifier><identifier>PMID: 18466866</identifier><identifier>CODEN: AJSUAB</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Biological and medical sciences ; Chemotherapy, Adjuvant ; Cholangiography ; Diagnosis ; Diagnostic Imaging ; Epidemiology ; Gallbladder cancer ; Gallbladder Neoplasms - diagnosis ; Gallbladder Neoplasms - epidemiology ; Gallbladder Neoplasms - etiology ; Gallbladder Neoplasms - therapy ; Gastroenterology. Liver. Pancreas. Abdomen ; General aspects ; Laparoscopy ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Medical sciences ; Neoplasm Staging ; Pathology ; Prognosis ; Radiotherapy, Adjuvant ; Risk Factors ; Surgery ; Treatment ; Tumors ; Womens health</subject><ispartof>The American journal of surgery, 2008-08, Vol.196 (2), p.252-264</ispartof><rights>Elsevier Inc.</rights><rights>2008 Elsevier Inc.</rights><rights>2008 INIST-CNRS</rights><rights>Copyright Elsevier Limited Aug 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c445t-18a1e19285aba7669b93479b0d9e193b45449c1813e5bf3320fee994c2b347ae3</citedby><cites>FETCH-LOGICAL-c445t-18a1e19285aba7669b93479b0d9e193b45449c1813e5bf3320fee994c2b347ae3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1444576446?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995,64385,64389,72469</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20535845$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18466866$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gourgiotis, Stavros, M.D., Ph.D</creatorcontrib><creatorcontrib>Kocher, Hemant M., M.D., F.R.C.S</creatorcontrib><creatorcontrib>Solaini, Leonardo, M.D</creatorcontrib><creatorcontrib>Yarollahi, Arvin, M.D</creatorcontrib><creatorcontrib>Tsiambas, Evangelos, M.D</creatorcontrib><creatorcontrib>Salemis, Nikolaos S., M.D., Ph.D</creatorcontrib><title>Gallbladder cancer</title><title>The American journal of surgery</title><addtitle>Am J Surg</addtitle><description>Abstract Background Gallbladder cancer (GC) is a relatively rare but highly lethal neoplasm. We review the epidemiology, etiology, pathology, symptoms, diagnosis, staging, treatment, and prognosis of GC. Method A Pubmed database search between 1971 and February 2007 was performed. All abstracts were reviewed and articles with GC obtained; further references were extracted by hand-searching the bibliography. The database search was done in the English language. Results The accurate etiology of GC remains unclear, while the symptoms associated with primary GC are not specific. Treatment with radical cholecystectomy is curative but possible in only 10% to 30% of patients. For patients whose cancer is an incidental finding on pathologic review, re-resection is indicated, where feasible, for all disease except T1a. Patients with advanced disease should receive palliative treatment. Laparoscopic cholecystectomy is contraindicated in the presence of GC. Conclusion Prognosis generally is extremely poor. Improvements in the outcome of surgical resection have caused this approach to be re-evaluated, while the role of chemotherapy and radiotherapy remains controversial.</description><subject>Biological and medical sciences</subject><subject>Chemotherapy, Adjuvant</subject><subject>Cholangiography</subject><subject>Diagnosis</subject><subject>Diagnostic Imaging</subject><subject>Epidemiology</subject><subject>Gallbladder cancer</subject><subject>Gallbladder Neoplasms - diagnosis</subject><subject>Gallbladder Neoplasms - epidemiology</subject><subject>Gallbladder Neoplasms - etiology</subject><subject>Gallbladder Neoplasms - therapy</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>General aspects</subject><subject>Laparoscopy</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Medical sciences</subject><subject>Neoplasm Staging</subject><subject>Pathology</subject><subject>Prognosis</subject><subject>Radiotherapy, Adjuvant</subject><subject>Risk Factors</subject><subject>Surgery</subject><subject>Treatment</subject><subject>Tumors</subject><subject>Womens health</subject><issn>0002-9610</issn><issn>1879-1883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkd1LwzAUxYMobn68-K4I4uNqbvPR5EWRoVMY-KA-hzS9ldZunckq7L83ZcWBLz6FhN89J-dcQs6BJkBB3tSJXdSh8x9JSmmWACQUYI-MQWV6AkqxfTKmlKYTLYGOyFEIdbwCcHZIRqC4lErKMTmb2abJG1sU6C-dXTr0J-SgtE3A0-E8Ju-PD2_Tp8n8ZfY8vZ9PHOdiHT0sIOhUCZvbTEqda8YzndNCx2eWc8G5dqCAochLxlJaImrNXZpHziI7Jldb3ZVvvzoMa1O3nV9GSwM8WmSScxkpsaWcb0PwWJqVrxbWbwxQ0zdhajM0YfomDICJMePcxaDe5QssdlND9AhcD4ANzjalj-Gr8MulVDChuIjc3ZbD2MV3hd4EV2Esqqg8urUp2urfr9z-UXBNtayi6SduMOxSm5Aaal77tfVboyouTGrOfgChZZAN</recordid><startdate>20080801</startdate><enddate>20080801</enddate><creator>Gourgiotis, Stavros, M.D., Ph.D</creator><creator>Kocher, Hemant M., M.D., F.R.C.S</creator><creator>Solaini, Leonardo, M.D</creator><creator>Yarollahi, Arvin, M.D</creator><creator>Tsiambas, Evangelos, M.D</creator><creator>Salemis, Nikolaos S., M.D., Ph.D</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope></search><sort><creationdate>20080801</creationdate><title>Gallbladder cancer</title><author>Gourgiotis, Stavros, M.D., Ph.D ; Kocher, Hemant M., M.D., F.R.C.S ; Solaini, Leonardo, M.D ; Yarollahi, Arvin, M.D ; Tsiambas, Evangelos, M.D ; Salemis, Nikolaos S., M.D., Ph.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c445t-18a1e19285aba7669b93479b0d9e193b45449c1813e5bf3320fee994c2b347ae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Biological and medical sciences</topic><topic>Chemotherapy, Adjuvant</topic><topic>Cholangiography</topic><topic>Diagnosis</topic><topic>Diagnostic Imaging</topic><topic>Epidemiology</topic><topic>Gallbladder cancer</topic><topic>Gallbladder Neoplasms - diagnosis</topic><topic>Gallbladder Neoplasms - epidemiology</topic><topic>Gallbladder Neoplasms - etiology</topic><topic>Gallbladder Neoplasms - therapy</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>General aspects</topic><topic>Laparoscopy</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Medical sciences</topic><topic>Neoplasm Staging</topic><topic>Pathology</topic><topic>Prognosis</topic><topic>Radiotherapy, Adjuvant</topic><topic>Risk Factors</topic><topic>Surgery</topic><topic>Treatment</topic><topic>Tumors</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gourgiotis, Stavros, M.D., Ph.D</creatorcontrib><creatorcontrib>Kocher, Hemant M., M.D., F.R.C.S</creatorcontrib><creatorcontrib>Solaini, Leonardo, M.D</creatorcontrib><creatorcontrib>Yarollahi, Arvin, M.D</creatorcontrib><creatorcontrib>Tsiambas, Evangelos, M.D</creatorcontrib><creatorcontrib>Salemis, Nikolaos S., M.D., Ph.D</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><jtitle>The American journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gourgiotis, Stavros, M.D., Ph.D</au><au>Kocher, Hemant M., M.D., F.R.C.S</au><au>Solaini, Leonardo, M.D</au><au>Yarollahi, Arvin, M.D</au><au>Tsiambas, Evangelos, M.D</au><au>Salemis, Nikolaos S., M.D., Ph.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gallbladder cancer</atitle><jtitle>The American journal of surgery</jtitle><addtitle>Am J Surg</addtitle><date>2008-08-01</date><risdate>2008</risdate><volume>196</volume><issue>2</issue><spage>252</spage><epage>264</epage><pages>252-264</pages><issn>0002-9610</issn><eissn>1879-1883</eissn><coden>AJSUAB</coden><abstract>Abstract Background Gallbladder cancer (GC) is a relatively rare but highly lethal neoplasm. We review the epidemiology, etiology, pathology, symptoms, diagnosis, staging, treatment, and prognosis of GC. Method A Pubmed database search between 1971 and February 2007 was performed. All abstracts were reviewed and articles with GC obtained; further references were extracted by hand-searching the bibliography. The database search was done in the English language. Results The accurate etiology of GC remains unclear, while the symptoms associated with primary GC are not specific. Treatment with radical cholecystectomy is curative but possible in only 10% to 30% of patients. For patients whose cancer is an incidental finding on pathologic review, re-resection is indicated, where feasible, for all disease except T1a. Patients with advanced disease should receive palliative treatment. Laparoscopic cholecystectomy is contraindicated in the presence of GC. Conclusion Prognosis generally is extremely poor. Improvements in the outcome of surgical resection have caused this approach to be re-evaluated, while the role of chemotherapy and radiotherapy remains controversial.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>18466866</pmid><doi>10.1016/j.amjsurg.2007.11.011</doi><tpages>13</tpages></addata></record> |
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| subjects | Biological and medical sciences Chemotherapy, Adjuvant Cholangiography Diagnosis Diagnostic Imaging Epidemiology Gallbladder cancer Gallbladder Neoplasms - diagnosis Gallbladder Neoplasms - epidemiology Gallbladder Neoplasms - etiology Gallbladder Neoplasms - therapy Gastroenterology. Liver. Pancreas. Abdomen General aspects Laparoscopy Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical sciences Neoplasm Staging Pathology Prognosis Radiotherapy, Adjuvant Risk Factors Surgery Treatment Tumors Womens health |
| title | Gallbladder cancer |
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