Quorum Sensing and Morphological Regulation in the Pathogenic Fungus Candida albicans

Quorum sensing is a cell-density effect and the regulation of gene expression in response to extracellular chemical signals (quorum-sensing molecules) produced by microorganisms. Hyphal induction in Candid albicans is inhibited by high cell density and also by farnesol, which is a quorum-sensing mol...

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Veröffentlicht in:Journal of oral biosciences 2010-01, Vol.52 (3), p.233-239
Hauptverfasser: Cho, Tamaki, Nagao, Jun-ichi, Imayoshi, Rieko, Kaminishi, Hidenori, Aoyama, Toshihiro, Nakayama, Hironobu
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container_title Journal of oral biosciences
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creator Cho, Tamaki
Nagao, Jun-ichi
Imayoshi, Rieko
Kaminishi, Hidenori
Aoyama, Toshihiro
Nakayama, Hironobu
description Quorum sensing is a cell-density effect and the regulation of gene expression in response to extracellular chemical signals (quorum-sensing molecules) produced by microorganisms. Hyphal induction in Candid albicans is inhibited by high cell density and also by farnesol, which is a quorum-sensing molecule of the organism. Here, we describe models of the regulation of dimorphism in Candida albicans by farnesol from the latest published data and gene regulation during the initial stages of quorum sensing, which was obtained through microarray analysis.
doi_str_mv 10.1016/S1349-0079(10)80026-X
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subjects Candida albicans
cell density
farnesol
quorum sensing
title Quorum Sensing and Morphological Regulation in the Pathogenic Fungus Candida albicans
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