Dentin Regeneration by Direct Pulp Capping using rhBMP-2

Dentin Regeneration by Direct Pulp Capping using rhBMP-2

The purpose of this study was to evaluate the effect of direct pulp capping using recombinant human BMP-2 (rhBMP-2) on dentin regeneration. RhBMP-2 (1.0 mg/ml) was dissolved in alginate-based gel (AG). Cavities with the exposed pulp area were prepared of first molars in Wister rats. All cavities wer...

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Veröffentlicht in:Journal of oral tissue engineering 2007-09, Vol.5 (3), p.145
Hauptverfasser: YAMAJI, Kozo, HORIKAWA, Gen, NISHITANI, Yoshihiro, IZAWA, Shunji, YOSHIYAMA, Masahiro
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container_title Journal of oral tissue engineering
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creator YAMAJI, Kozo
HORIKAWA, Gen
NISHITANI, Yoshihiro
IZAWA, Shunji
YOSHIYAMA, Masahiro
description The purpose of this study was to evaluate the effect of direct pulp capping using recombinant human BMP-2 (rhBMP-2) on dentin regeneration. RhBMP-2 (1.0 mg/ml) was dissolved in alginate-based gel (AG). Cavities with the exposed pulp area were prepared of first molars in Wister rats. All cavities were divided into two groups: The exposed pulps were covered with AG contained rhBMP-2 (BMP group), and covered with AG alone (AG group). Then they were sealed with glass ionomer cement (Fuji IILC EM). The animals were sacrificed at 3 and 8 weeks after operation. In both groups, the covered materials were observed at 3 weeks after operation, while they had disappeared and the tertiary dentin formation was observed into the prepared cavity at 8 weeks after operation. Thickness of the tertiary dentin of BMP group was significantly higher than that of AG group (P
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