Formulation and in vitro Evaluation of Ketoprofen in Palm Oil Esters Nanoemulsion for Topical Delivery
The aim of the present study is to formulate and investigate the potential of nanoemulsion formulation for topical delivery of ketoprofen. In this study, Palm Oil Esters (POEs) a newly introduced oil by Universiti Putra Malaysia researchers was chosen for the oil phase of the nanoemulsion, because t...
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| Veröffentlicht in: | Journal of Oleo Science 2010, Vol.59(4), pp.223-228 |
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| container_title | Journal of Oleo Science |
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| creator | Sakeena, M.H.F. F.A., Muthanna Z.A., Ghassan M.M., Kanakal S.M., Elrashid A.S., Munavvar M.N., Azmin |
| description | The aim of the present study is to formulate and investigate the potential of nanoemulsion formulation for topical delivery of ketoprofen. In this study, Palm Oil Esters (POEs) a newly introduced oil by Universiti Putra Malaysia researchers was chosen for the oil phase of the nanoemulsion, because the oil was reported to be a good vehicle for pharmaceutical use. Oil-in-water nanoemulsion was prepared by spontaneous emulsification method. The droplets size was studied by laser scattering spectroscopy (Nanophox) and Transmission Electron Microscopy (TEM). Franz diffusion cells were used, to determine the drug release and drug transferred through methyl acetate cellulose membrane (artificial membrane). The results of droplets size analysis shows the droplets are in the range of nanoemulsion which is below than 500 nm. The in vitro release profile shows a sufficient percentage of drugs released through the methyl acetate cellulose membrane. This initial study showed that the nanoemulsion formulated using POEs has great potential for topical delivery of ketoprofen. |
| doi_str_mv | 10.5650/jos.59.223 |
| format | Article |
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In this study, Palm Oil Esters (POEs) a newly introduced oil by Universiti Putra Malaysia researchers was chosen for the oil phase of the nanoemulsion, because the oil was reported to be a good vehicle for pharmaceutical use. Oil-in-water nanoemulsion was prepared by spontaneous emulsification method. The droplets size was studied by laser scattering spectroscopy (Nanophox) and Transmission Electron Microscopy (TEM). Franz diffusion cells were used, to determine the drug release and drug transferred through methyl acetate cellulose membrane (artificial membrane). The results of droplets size analysis shows the droplets are in the range of nanoemulsion which is below than 500 nm. The in vitro release profile shows a sufficient percentage of drugs released through the methyl acetate cellulose membrane. This initial study showed that the nanoemulsion formulated using POEs has great potential for topical delivery of ketoprofen.</description><identifier>ISSN: 1345-8957</identifier><identifier>EISSN: 1347-3352</identifier><identifier>DOI: 10.5650/jos.59.223</identifier><identifier>PMID: 20299769</identifier><language>eng</language><publisher>Japan: Japan Oil Chemists' Society</publisher><subject>Administration, Topical ; Cell Membrane Permeability ; Chemistry, Pharmaceutical ; Drug Delivery Systems ; Emulsions ; Esters ; ketoprofen ; Ketoprofen - administration & dosage ; Ketoprofen - pharmacokinetics ; Membranes, Artificial ; Methylcellulose ; Nanoparticles ; Palm Oil ; palm oil esters ; Particle Size ; Plant Oils ; topical delivery ; Water</subject><ispartof>Journal of Oleo Science, 2010, Vol.59(4), pp.223-228</ispartof><rights>2010 by Japan Oil Chemists' Society</rights><rights>Copyright Japan Science and Technology Agency 2010</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c610t-6771bc78e8fb1e3672d0ca0701cb700f7b4587e7ac64a497a8d2b386ba1b0f943</citedby><cites>FETCH-LOGICAL-c610t-6771bc78e8fb1e3672d0ca0701cb700f7b4587e7ac64a497a8d2b386ba1b0f943</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1881,4022,27921,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20299769$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sakeena, M.H.F.</creatorcontrib><creatorcontrib>F.A., Muthanna</creatorcontrib><creatorcontrib>Z.A., Ghassan</creatorcontrib><creatorcontrib>M.M., Kanakal</creatorcontrib><creatorcontrib>S.M., Elrashid</creatorcontrib><creatorcontrib>A.S., Munavvar</creatorcontrib><creatorcontrib>M.N., Azmin</creatorcontrib><creatorcontrib>School of Pharmaceutical Sciences</creatorcontrib><creatorcontrib>Department of Pharmaceutical Technology</creatorcontrib><creatorcontrib>Universiti Sains Malaysia</creatorcontrib><creatorcontrib>Department of Physiology</creatorcontrib><title>Formulation and in vitro Evaluation of Ketoprofen in Palm Oil Esters Nanoemulsion for Topical Delivery</title><title>Journal of Oleo Science</title><addtitle>J Oleo Sci</addtitle><description>The aim of the present study is to formulate and investigate the potential of nanoemulsion formulation for topical delivery of ketoprofen. In this study, Palm Oil Esters (POEs) a newly introduced oil by Universiti Putra Malaysia researchers was chosen for the oil phase of the nanoemulsion, because the oil was reported to be a good vehicle for pharmaceutical use. Oil-in-water nanoemulsion was prepared by spontaneous emulsification method. The droplets size was studied by laser scattering spectroscopy (Nanophox) and Transmission Electron Microscopy (TEM). Franz diffusion cells were used, to determine the drug release and drug transferred through methyl acetate cellulose membrane (artificial membrane). The results of droplets size analysis shows the droplets are in the range of nanoemulsion which is below than 500 nm. The in vitro release profile shows a sufficient percentage of drugs released through the methyl acetate cellulose membrane. This initial study showed that the nanoemulsion formulated using POEs has great potential for topical delivery of ketoprofen.</description><subject>Administration, Topical</subject><subject>Cell Membrane Permeability</subject><subject>Chemistry, Pharmaceutical</subject><subject>Drug Delivery Systems</subject><subject>Emulsions</subject><subject>Esters</subject><subject>ketoprofen</subject><subject>Ketoprofen - administration & dosage</subject><subject>Ketoprofen - pharmacokinetics</subject><subject>Membranes, Artificial</subject><subject>Methylcellulose</subject><subject>Nanoparticles</subject><subject>Palm Oil</subject><subject>palm oil esters</subject><subject>Particle Size</subject><subject>Plant Oils</subject><subject>topical delivery</subject><subject>Water</subject><issn>1345-8957</issn><issn>1347-3352</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkFFvFCEQgDdG09baF3-AIfHNZM9hgQWejKl3amzaPtRnwrKssuHghN1L-u9l3V59mSHMN9_AVNVbDBvWMvg4xrxhctM05EV1gQnlNSGsefnvzGohGT-vXuc8ApR7xs-q8wYaKXkrL6phF9N-9npyMSAdeuQCOropRbQ9aj-v93FAP-wUDykONizEvfZ7dOc82ubJpoxudYi2aPJCDzGhh3hwRnv0xXp3tOnxTfVq0D7bq6d8Wf3cbR-uv9U3d1-_X3--qU2LYapbznFnuLBi6LAlLW96MBo4YNNxgIF3lAluuTYt1VRyLfqmI6LtNO5gkJRcVu9Xb3nrn9nmSY1xTqGMVJhSCkRKRgr1YaVMijknO6hDcnudHhUGtay0dGXFpCorLfC7J-Xc7W3_jJ52WIDdCpTq8ukYvAv2_-B-5NHbImyg6AGYBFqSUFD0SxCcCUl5EX1aRWOe9C_7PEmnyRlvT4-ia1iaTxXzWydlA_kLuPSfSQ</recordid><startdate>2010</startdate><enddate>2010</enddate><creator>Sakeena, M.H.F.</creator><creator>F.A., Muthanna</creator><creator>Z.A., Ghassan</creator><creator>M.M., Kanakal</creator><creator>S.M., Elrashid</creator><creator>A.S., Munavvar</creator><creator>M.N., Azmin</creator><general>Japan Oil Chemists' Society</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope></search><sort><creationdate>2010</creationdate><title>Formulation and in vitro Evaluation of Ketoprofen in Palm Oil Esters Nanoemulsion for Topical Delivery</title><author>Sakeena, M.H.F. ; 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| subjects | Administration, Topical Cell Membrane Permeability Chemistry, Pharmaceutical Drug Delivery Systems Emulsions Esters ketoprofen Ketoprofen - administration & dosage Ketoprofen - pharmacokinetics Membranes, Artificial Methylcellulose Nanoparticles Palm Oil palm oil esters Particle Size Plant Oils topical delivery Water |
| title | Formulation and in vitro Evaluation of Ketoprofen in Palm Oil Esters Nanoemulsion for Topical Delivery |
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