Conjugated Linoleic Acid Reduces Hepatic Microsomal Triacylglycerol Transfer Protein Activity and Hepatic Triacylglycerol Mass in Obese Rats
Conjugated linoleic acid (CLA) is known to modulate lipid and lipoprotein metabolism. We examined the effects of dietary CLA (1 and 2%) on hepatic microsomal triacylglycerol transfer protein (MTP) activity, known to be essential for the assembly/secretion of the apolipoprotein B-containing lipoprote...
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| Veröffentlicht in: | Journal of Oleo Science 2003, Vol.52(3), pp.129-134 |
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| container_title | Journal of Oleo Science |
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| creator | WANG, Yu-Ming RAHMAN, Shaikh Mizanoor NAGAO, Koji HAN, Seo-Young BUANG, Yohanes CHA, Jae-Young YANAGITA, Teruyoshi |
| description | Conjugated linoleic acid (CLA) is known to modulate lipid and lipoprotein metabolism. We examined the effects of dietary CLA (1 and 2%) on hepatic microsomal triacylglycerol transfer protein (MTP) activity, known to be essential for the assembly/secretion of the apolipoprotein B-containing lipoproteins, and lipid concentrations of liver and plasma in OLETF obese rats. A significant reduction in hepatic MTP activity in CLA-fed rats in comparison to rats fed a linoleic acid (LA) diet was noted. Hepatic and serum triacylglycerol (TAG) concentrations were lowered in the CLA groups as compared to the control LA group. Decreased serum insulin and leptin levels were seen in the CLA groups. These results indicate that dietary CLA reduces both hepatic MTP activity and TAG content, and therefore reduces hepatic lipoprotein assembly and secretion. |
| doi_str_mv | 10.5650/jos.52.129 |
| format | Article |
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We examined the effects of dietary CLA (1 and 2%) on hepatic microsomal triacylglycerol transfer protein (MTP) activity, known to be essential for the assembly/secretion of the apolipoprotein B-containing lipoproteins, and lipid concentrations of liver and plasma in OLETF obese rats. A significant reduction in hepatic MTP activity in CLA-fed rats in comparison to rats fed a linoleic acid (LA) diet was noted. Hepatic and serum triacylglycerol (TAG) concentrations were lowered in the CLA groups as compared to the control LA group. Decreased serum insulin and leptin levels were seen in the CLA groups. These results indicate that dietary CLA reduces both hepatic MTP activity and TAG content, and therefore reduces hepatic lipoprotein assembly and secretion.</description><identifier>ISSN: 1345-8957</identifier><identifier>EISSN: 1347-3352</identifier><identifier>DOI: 10.5650/jos.52.129</identifier><language>eng</language><publisher>Tokyo: Japan Oil Chemists' Society</publisher><subject>conjugated linoleic acid ; liver ; microsomal triacylglycerol transfer protein ; obese rat ; VLDL</subject><ispartof>Journal of Oleo Science, 2003, Vol.52(3), pp.129-134</ispartof><rights>2003 by Japan Oil Chemists' Society</rights><rights>Copyright Japan Science and Technology Agency 2003</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4769-809c07b0929a19eb82030e53fcc5959d8f708946b575f28ddc94e5b95b6bcf4b3</citedby><cites>FETCH-LOGICAL-c4769-809c07b0929a19eb82030e53fcc5959d8f708946b575f28ddc94e5b95b6bcf4b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,4010,27900,27901,27902</link.rule.ids></links><search><creatorcontrib>WANG, Yu-Ming</creatorcontrib><creatorcontrib>RAHMAN, Shaikh Mizanoor</creatorcontrib><creatorcontrib>NAGAO, Koji</creatorcontrib><creatorcontrib>HAN, Seo-Young</creatorcontrib><creatorcontrib>BUANG, Yohanes</creatorcontrib><creatorcontrib>CHA, Jae-Young</creatorcontrib><creatorcontrib>YANAGITA, Teruyoshi</creatorcontrib><creatorcontrib>Department of Applied Biological Sciences</creatorcontrib><creatorcontrib>Laboratory of Nutrition Biochemistry</creatorcontrib><creatorcontrib>Saga University</creatorcontrib><creatorcontrib>Department of Biochemistry</creatorcontrib><creatorcontrib>University of Wisconsin-Madison</creatorcontrib><title>Conjugated Linoleic Acid Reduces Hepatic Microsomal Triacylglycerol Transfer Protein Activity and Hepatic Triacylglycerol Mass in Obese Rats</title><title>Journal of Oleo Science</title><description>Conjugated linoleic acid (CLA) is known to modulate lipid and lipoprotein metabolism. We examined the effects of dietary CLA (1 and 2%) on hepatic microsomal triacylglycerol transfer protein (MTP) activity, known to be essential for the assembly/secretion of the apolipoprotein B-containing lipoproteins, and lipid concentrations of liver and plasma in OLETF obese rats. A significant reduction in hepatic MTP activity in CLA-fed rats in comparison to rats fed a linoleic acid (LA) diet was noted. Hepatic and serum triacylglycerol (TAG) concentrations were lowered in the CLA groups as compared to the control LA group. Decreased serum insulin and leptin levels were seen in the CLA groups. These results indicate that dietary CLA reduces both hepatic MTP activity and TAG content, and therefore reduces hepatic lipoprotein assembly and secretion.</description><subject>conjugated linoleic acid</subject><subject>liver</subject><subject>microsomal triacylglycerol transfer protein</subject><subject>obese rat</subject><subject>VLDL</subject><issn>1345-8957</issn><issn>1347-3352</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><recordid>eNpdUM1q3DAQNqWFpkkueQJBbwVv9GtZpxKWNilsSAjpWcjSeCvjlbaSN7Dv0IeuHCcp9DIzmvl-0FdVFwSvRCPw5RDzStAVoepddUIYlzVjgr5_nkXdKiE_Vp9yHjAueyFPqj_rGIbD1kzg0MaHOIK36Mp6hx7AHSxkdAN7M5Xlrbcp5rgzI3pM3tjjuB2PFlKc3ybkHhK6T3ECH4rA5J_8dEQmuDeB_1m3JmdUwHcdZEAPZspn1YfejBnOX_pp9fP7t8f1Tb25u_6xvtrUlstG1S1WFssOK6oMUdC1FDMMgvXWCiWUa3uJW8WbTkjR09Y5qziITomu6WzPO3ZafV509yn-PkCe9BAPKRRLTTjnmBDVyIL6sqDmf-cEvd4nvzPpqAnWc9qFlbWguqRdwNcLeAfOWzPGMPoA_3TdIEu2BU9L9BpjQZ8b1biwS2GcYKkaMdt-XZSGPJktvJmaVEIc4dWULWVmv17sL5M0BPYXxqKh0A</recordid><startdate>2003</startdate><enddate>2003</enddate><creator>WANG, Yu-Ming</creator><creator>RAHMAN, Shaikh Mizanoor</creator><creator>NAGAO, Koji</creator><creator>HAN, Seo-Young</creator><creator>BUANG, Yohanes</creator><creator>CHA, Jae-Young</creator><creator>YANAGITA, Teruyoshi</creator><general>Japan Oil Chemists' Society</general><general>Japan Science and Technology Agency</general><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope></search><sort><creationdate>2003</creationdate><title>Conjugated Linoleic Acid Reduces Hepatic Microsomal Triacylglycerol Transfer Protein Activity and Hepatic Triacylglycerol Mass in Obese Rats</title><author>WANG, Yu-Ming ; RAHMAN, Shaikh Mizanoor ; NAGAO, Koji ; HAN, Seo-Young ; BUANG, Yohanes ; CHA, Jae-Young ; YANAGITA, Teruyoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4769-809c07b0929a19eb82030e53fcc5959d8f708946b575f28ddc94e5b95b6bcf4b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>conjugated linoleic acid</topic><topic>liver</topic><topic>microsomal triacylglycerol transfer protein</topic><topic>obese rat</topic><topic>VLDL</topic><toplevel>online_resources</toplevel><creatorcontrib>WANG, Yu-Ming</creatorcontrib><creatorcontrib>RAHMAN, Shaikh Mizanoor</creatorcontrib><creatorcontrib>NAGAO, Koji</creatorcontrib><creatorcontrib>HAN, Seo-Young</creatorcontrib><creatorcontrib>BUANG, Yohanes</creatorcontrib><creatorcontrib>CHA, Jae-Young</creatorcontrib><creatorcontrib>YANAGITA, Teruyoshi</creatorcontrib><creatorcontrib>Department of Applied Biological Sciences</creatorcontrib><creatorcontrib>Laboratory of Nutrition Biochemistry</creatorcontrib><creatorcontrib>Saga University</creatorcontrib><creatorcontrib>Department of Biochemistry</creatorcontrib><creatorcontrib>University of Wisconsin-Madison</creatorcontrib><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><jtitle>Journal of Oleo Science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>WANG, Yu-Ming</au><au>RAHMAN, Shaikh Mizanoor</au><au>NAGAO, Koji</au><au>HAN, Seo-Young</au><au>BUANG, Yohanes</au><au>CHA, Jae-Young</au><au>YANAGITA, Teruyoshi</au><aucorp>Department of Applied Biological Sciences</aucorp><aucorp>Laboratory of Nutrition Biochemistry</aucorp><aucorp>Saga University</aucorp><aucorp>Department of Biochemistry</aucorp><aucorp>University of Wisconsin-Madison</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Conjugated Linoleic Acid Reduces Hepatic Microsomal Triacylglycerol Transfer Protein Activity and Hepatic Triacylglycerol Mass in Obese Rats</atitle><jtitle>Journal of Oleo Science</jtitle><date>2003</date><risdate>2003</risdate><volume>52</volume><issue>3</issue><spage>129</spage><epage>134</epage><pages>129-134</pages><issn>1345-8957</issn><eissn>1347-3352</eissn><abstract>Conjugated linoleic acid (CLA) is known to modulate lipid and lipoprotein metabolism. We examined the effects of dietary CLA (1 and 2%) on hepatic microsomal triacylglycerol transfer protein (MTP) activity, known to be essential for the assembly/secretion of the apolipoprotein B-containing lipoproteins, and lipid concentrations of liver and plasma in OLETF obese rats. A significant reduction in hepatic MTP activity in CLA-fed rats in comparison to rats fed a linoleic acid (LA) diet was noted. Hepatic and serum triacylglycerol (TAG) concentrations were lowered in the CLA groups as compared to the control LA group. Decreased serum insulin and leptin levels were seen in the CLA groups. These results indicate that dietary CLA reduces both hepatic MTP activity and TAG content, and therefore reduces hepatic lipoprotein assembly and secretion.</abstract><cop>Tokyo</cop><pub>Japan Oil Chemists' Society</pub><doi>10.5650/jos.52.129</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | conjugated linoleic acid liver microsomal triacylglycerol transfer protein obese rat VLDL |
| title | Conjugated Linoleic Acid Reduces Hepatic Microsomal Triacylglycerol Transfer Protein Activity and Hepatic Triacylglycerol Mass in Obese Rats |
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