Different Effects of Serum Iron Status on the Relationship between Blood Lead and Zinc Protoporphyrin in Lead Workers in Korea
This study was conducted to determine whether there was a different toxic effect of lead on heme synthesis by serum iron status in 360 lead workers in Korea. We examined the association between blood lead (PbB) and zinc protoporphyrin (ZPP) in whole blood according to the level of serum iron in low...
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| Veröffentlicht in: | Journal of Occupational Health 1999-07, Vol.41 (3), p.166-171 |
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| container_title | Journal of Occupational Health |
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| creator | Ahn, Hyun‐Cheol Hwang, Kyu‐Yoon Kim, Yong‐Bae Lee, Gap‐Soo Lee, Sung‐Soo Ahn, Kyu‐Dong Lee, Byung‐Kook |
| description | This study was conducted to determine whether there was a different toxic effect of lead on heme synthesis by serum iron status in 360 lead workers in Korea. We examined the association between blood lead (PbB) and zinc protoporphyrin (ZPP) in whole blood according to the level of serum iron in low to moderate lead-exposed workers in 1997-1998. Serum iron levels (FeS) were divided into two groups： iron-deficient group (serum iron |
| doi_str_mv | 10.1539/joh.41.166 |
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We examined the association between blood lead (PbB) and zinc protoporphyrin (ZPP) in whole blood according to the level of serum iron in low to moderate lead-exposed workers in 1997-1998. Serum iron levels (FeS) were divided into two groups： iron-deficient group (serum iron <80 μg/dl, 57 subjects) and iron-sufficient group (serum iron ≧ 80 μg/dl, 303 subjects). Blood lead corrected by the standard value for hemoglobin (15 g/dl) as an explanatory variable was assessed to explain the variance of ZPP. After adjusting for possible confounders, such as age, body mass index (BMI), cigarette smoking, alcohol drinking, and size of factory, the linear slope of corrected PbB on ZPP in the iron-deficient group was statistically higher than that of the iron-sufficient group. The interaction term between corrected PbB and ZPP with the modification of the serum iron status was statistically significant in the regression model (p=0.0053). The result suggests that the relationship between corrected PbB and ZPP may be modified by the serum iron status in male lead-exposed workers.</description><identifier>ISSN: 1341-9145</identifier><identifier>ISSN: 1348-9585</identifier><identifier>EISSN: 1348-9585</identifier><identifier>DOI: 10.1539/joh.41.166</identifier><language>eng</language><publisher>Tokyo: JAPAN SOCIETY FOR OCCUPATIONAL HEALTH</publisher><subject>Blood levels ; Corrected blood lead ; Interaction ; Iron sulfides ; Lead ; Lead poisoning ; Lead worker ; Occupational health ; Serum iron ; Zinc ; ZPP</subject><ispartof>Journal of Occupational Health, 1999-07, Vol.41 (3), p.166-171</ispartof><rights>1999 Japan Society for Occupational Health</rights><rights>Copyright Japan Science and Technology Agency 1999</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5506-9d87009d7dfd4ff531c04ad2b6bf50451f7aa07a3b6548a3e666324aa2348a453</citedby><cites>FETCH-LOGICAL-c5506-9d87009d7dfd4ff531c04ad2b6bf50451f7aa07a3b6548a3e666324aa2348a453</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1539%2Fjoh.41.166$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1539%2Fjoh.41.166$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids></links><search><creatorcontrib>Ahn, Hyun‐Cheol</creatorcontrib><creatorcontrib>Hwang, Kyu‐Yoon</creatorcontrib><creatorcontrib>Kim, Yong‐Bae</creatorcontrib><creatorcontrib>Lee, Gap‐Soo</creatorcontrib><creatorcontrib>Lee, Sung‐Soo</creatorcontrib><creatorcontrib>Ahn, Kyu‐Dong</creatorcontrib><creatorcontrib>Lee, Byung‐Kook</creatorcontrib><creatorcontrib>School of Medicine</creatorcontrib><creatorcontrib>The Johns Hopkins University</creatorcontrib><creatorcontrib>Soonchunhyang University</creatorcontrib><creatorcontrib>Department of Environmental Health Science</creatorcontrib><creatorcontrib>School of Hygiene and Public Health</creatorcontrib><creatorcontrib>Department of Preventive Medicine and Institute of Industrial Medicine</creatorcontrib><title>Different Effects of Serum Iron Status on the Relationship between Blood Lead and Zinc Protoporphyrin in Lead Workers in Korea</title><title>Journal of Occupational Health</title><description>This study was conducted to determine whether there was a different toxic effect of lead on heme synthesis by serum iron status in 360 lead workers in Korea. We examined the association between blood lead (PbB) and zinc protoporphyrin (ZPP) in whole blood according to the level of serum iron in low to moderate lead-exposed workers in 1997-1998. Serum iron levels (FeS) were divided into two groups： iron-deficient group (serum iron <80 μg/dl, 57 subjects) and iron-sufficient group (serum iron ≧ 80 μg/dl, 303 subjects). Blood lead corrected by the standard value for hemoglobin (15 g/dl) as an explanatory variable was assessed to explain the variance of ZPP. After adjusting for possible confounders, such as age, body mass index (BMI), cigarette smoking, alcohol drinking, and size of factory, the linear slope of corrected PbB on ZPP in the iron-deficient group was statistically higher than that of the iron-sufficient group. The interaction term between corrected PbB and ZPP with the modification of the serum iron status was statistically significant in the regression model (p=0.0053). The result suggests that the relationship between corrected PbB and ZPP may be modified by the serum iron status in male lead-exposed workers.</description><subject>Blood levels</subject><subject>Corrected blood lead</subject><subject>Interaction</subject><subject>Iron sulfides</subject><subject>Lead</subject><subject>Lead poisoning</subject><subject>Lead worker</subject><subject>Occupational health</subject><subject>Serum iron</subject><subject>Zinc</subject><subject>ZPP</subject><issn>1341-9145</issn><issn>1348-9585</issn><issn>1348-9585</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><recordid>eNp9kE-LFDEQxRtRcFn34icIeBN6THX-dPdR1113dWDFVQQvId2p0Fl7kjbJsMzFz256RvAmBOpV8nuV4lXVS6AbEKx_8xCmDYcNSPmkOgPGu7oXnXh61FD3wMXz6iIlN9CGgWhBsrPq93tnLUb0mVwVMeZEgiX3GPc7chuDJ_dZ53259CRPSL7grLMLPk1uIQPmR0RP3s0hGLJFbYj2hvxwfiSfY8hhCXGZDtF5Us7x_XuIPzGmtf8UIuoX1TOr54QXf-t59e366uvlTb29-3B7-XZbj0JQWfemayntTWus4dYKBiPl2jSDHKygXIBttaatZoMUvNMMpZSs4Vo3JQXNBTuvXp3mLjH82mPK6iHsoy9fKuCctVDSgEK9PlFjDClFtGqJbqfjQQFVa8TFNSkOqkRcYHGCH92Mh_-Q6uPdTUM5UMooXX3XJ98OjRv1HPzsPP7bZ7TtUSvo-17R1chKkYqus2jZlAvRScH-AIsylRU</recordid><startdate>199907</startdate><enddate>199907</enddate><creator>Ahn, Hyun‐Cheol</creator><creator>Hwang, Kyu‐Yoon</creator><creator>Kim, Yong‐Bae</creator><creator>Lee, Gap‐Soo</creator><creator>Lee, Sung‐Soo</creator><creator>Ahn, Kyu‐Dong</creator><creator>Lee, Byung‐Kook</creator><general>JAPAN SOCIETY FOR OCCUPATIONAL HEALTH</general><general>John Wiley & Sons, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7TA</scope><scope>7TB</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>JG9</scope><scope>KR7</scope><scope>NAPCQ</scope></search><sort><creationdate>199907</creationdate><title>Different Effects of Serum Iron Status on the Relationship between Blood Lead and Zinc Protoporphyrin in Lead Workers in Korea</title><author>Ahn, Hyun‐Cheol ; Hwang, Kyu‐Yoon ; Kim, Yong‐Bae ; Lee, Gap‐Soo ; Lee, Sung‐Soo ; Ahn, Kyu‐Dong ; Lee, Byung‐Kook</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5506-9d87009d7dfd4ff531c04ad2b6bf50451f7aa07a3b6548a3e666324aa2348a453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Blood levels</topic><topic>Corrected blood lead</topic><topic>Interaction</topic><topic>Iron sulfides</topic><topic>Lead</topic><topic>Lead poisoning</topic><topic>Lead worker</topic><topic>Occupational health</topic><topic>Serum iron</topic><topic>Zinc</topic><topic>ZPP</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ahn, Hyun‐Cheol</creatorcontrib><creatorcontrib>Hwang, Kyu‐Yoon</creatorcontrib><creatorcontrib>Kim, Yong‐Bae</creatorcontrib><creatorcontrib>Lee, Gap‐Soo</creatorcontrib><creatorcontrib>Lee, Sung‐Soo</creatorcontrib><creatorcontrib>Ahn, Kyu‐Dong</creatorcontrib><creatorcontrib>Lee, Byung‐Kook</creatorcontrib><creatorcontrib>School of Medicine</creatorcontrib><creatorcontrib>The Johns Hopkins University</creatorcontrib><creatorcontrib>Soonchunhyang University</creatorcontrib><creatorcontrib>Department of Environmental Health Science</creatorcontrib><creatorcontrib>School of Hygiene and Public Health</creatorcontrib><creatorcontrib>Department of Preventive Medicine and Institute of Industrial Medicine</creatorcontrib><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Materials Research Database</collection><collection>Civil Engineering Abstracts</collection><collection>Nursing & Allied Health Premium</collection><jtitle>Journal of Occupational Health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ahn, Hyun‐Cheol</au><au>Hwang, Kyu‐Yoon</au><au>Kim, Yong‐Bae</au><au>Lee, Gap‐Soo</au><au>Lee, Sung‐Soo</au><au>Ahn, Kyu‐Dong</au><au>Lee, Byung‐Kook</au><aucorp>School of Medicine</aucorp><aucorp>The Johns Hopkins University</aucorp><aucorp>Soonchunhyang University</aucorp><aucorp>Department of Environmental Health Science</aucorp><aucorp>School of Hygiene and Public Health</aucorp><aucorp>Department of Preventive Medicine and Institute of Industrial Medicine</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Different Effects of Serum Iron Status on the Relationship between Blood Lead and Zinc Protoporphyrin in Lead Workers in Korea</atitle><jtitle>Journal of Occupational Health</jtitle><date>1999-07</date><risdate>1999</risdate><volume>41</volume><issue>3</issue><spage>166</spage><epage>171</epage><pages>166-171</pages><issn>1341-9145</issn><issn>1348-9585</issn><eissn>1348-9585</eissn><abstract>This study was conducted to determine whether there was a different toxic effect of lead on heme synthesis by serum iron status in 360 lead workers in Korea. We examined the association between blood lead (PbB) and zinc protoporphyrin (ZPP) in whole blood according to the level of serum iron in low to moderate lead-exposed workers in 1997-1998. Serum iron levels (FeS) were divided into two groups： iron-deficient group (serum iron <80 μg/dl, 57 subjects) and iron-sufficient group (serum iron ≧ 80 μg/dl, 303 subjects). Blood lead corrected by the standard value for hemoglobin (15 g/dl) as an explanatory variable was assessed to explain the variance of ZPP. After adjusting for possible confounders, such as age, body mass index (BMI), cigarette smoking, alcohol drinking, and size of factory, the linear slope of corrected PbB on ZPP in the iron-deficient group was statistically higher than that of the iron-sufficient group. The interaction term between corrected PbB and ZPP with the modification of the serum iron status was statistically significant in the regression model (p=0.0053). The result suggests that the relationship between corrected PbB and ZPP may be modified by the serum iron status in male lead-exposed workers.</abstract><cop>Tokyo</cop><pub>JAPAN SOCIETY FOR OCCUPATIONAL HEALTH</pub><doi>10.1539/joh.41.166</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Blood levels Corrected blood lead Interaction Iron sulfides Lead Lead poisoning Lead worker Occupational health Serum iron Zinc ZPP |
| title | Different Effects of Serum Iron Status on the Relationship between Blood Lead and Zinc Protoporphyrin in Lead Workers in Korea |
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