Preimplantation genetic diagnosis

Preimplantation genetic diagnosis

Preimplantation genetic diagnosis (PGD) is a technology that allows for the selection and transfer of embryos unaffected by genetic disease. The limited number of cells available for genetic testing is a weakness of PGD and has been solved by means of the development of various strategies such as po...

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Veröffentlicht in:Journal of mammalian ova research 2004-01, Vol.21 (1), p.2-6
Hauptverfasser: Sasabe, Y, Nishimura, T, Kubo, H
Format: Artikel
Sprache:eng
Schlagworte:
ANEUPLOIDY
CELLS
DIAGNOSIS
GENETIC DISORDERS
MANKIND
NIDATION
PCR
RECYCLING
TECHNICAL PROPERTIES
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container_title Journal of mammalian ova research
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creator Sasabe, Y
Nishimura, T
Kubo, H
description Preimplantation genetic diagnosis (PGD) is a technology that allows for the selection and transfer of embryos unaffected by genetic disease. The limited number of cells available for genetic testing is a weakness of PGD and has been solved by means of the development of various strategies such as polymerase chain reaction (PCR), fluorescence in situ hybridization (FISH) and cell recycling. A confounding factor in PGD is the existence of preimplantation embryos with severe chromosomal abnormalities. Therefore, genetic analysis should be performed with the assumption that embryos have severe chromosomal abnormalities. The visualization of metaphase plates allows screening for numerical chromosomal abnormality and several kinds of structural chromosomal abnormality. In addition, in vitro culture of single isolated blastomeres makes it possible to reexamine samples to ensure accuracy of the results and to obtain additional genetic information.
doi_str_mv 10.1274/jmor.21.2
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source Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; AgriKnowledge（アグリナレッジ）AGROLib
subjects ANEUPLOIDY
CELLS
DIAGNOSIS
GENETIC DISORDERS
MANKIND
NIDATION
PCR
RECYCLING
TECHNICAL PROPERTIES
title Preimplantation genetic diagnosis
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