Effects of androgens on early development of mouse follicles in organ-cultured ovaries
Ovaries from 4-day-old mice were organ-cultured and the effects of progesterone, androstenedione and estradiol-17β on early follicular development were investigated. Both androstenedione (40-1,000 ng/ml) and estradiol-17β (8-1,000 ng/ml) promoted proliferation of granulosa cells in developing follic...
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| Veröffentlicht in: | Journal of mammalian ova research 1999, Vol.16 (3), p.148-153 |
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| container_title | Journal of mammalian ova research |
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| creator | Ikeda, Y. (Kobe Univ. (Japan). Faculty of Agriculture) Hirao, Y Miyano, T |
| description | Ovaries from 4-day-old mice were organ-cultured and the effects of progesterone, androstenedione and estradiol-17β on early follicular development were investigated. Both androstenedione (40-1,000 ng/ml) and estradiol-17β (8-1,000 ng/ml) promoted proliferation of granulosa cells in developing follicles, while progesterone showed no remarkable effect. Cyproterone acetate (4,000 ng/ml), an androgen receptor antagonist, partially inhibited the granulosa cell proliferation induced by androstenedione (40 ng/ml). Dihydrotestosterone (8-1,000 ng/ml), which is not converted to estrogens, also induced proliferation of granulosa cells. These results suggest that androgens directly promote proliferation of granulosa cells in early developing mouse follicles in vitro. |
| doi_str_mv | 10.1274/jmor.16.148 |
| format | Article |
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(Kobe Univ. (Japan). Faculty of Agriculture) ; Hirao, Y ; Miyano, T</creator><creatorcontrib>Ikeda, Y. (Kobe Univ. (Japan). Faculty of Agriculture) ; Hirao, Y ; Miyano, T</creatorcontrib><description>Ovaries from 4-day-old mice were organ-cultured and the effects of progesterone, androstenedione and estradiol-17β on early follicular development were investigated. Both androstenedione (40-1,000 ng/ml) and estradiol-17β (8-1,000 ng/ml) promoted proliferation of granulosa cells in developing follicles, while progesterone showed no remarkable effect. Cyproterone acetate (4,000 ng/ml), an androgen receptor antagonist, partially inhibited the granulosa cell proliferation induced by androstenedione (40 ng/ml). Dihydrotestosterone (8-1,000 ng/ml), which is not converted to estrogens, also induced proliferation of granulosa cells. These results suggest that androgens directly promote proliferation of granulosa cells in early developing mouse follicles in vitro.</description><identifier>ISSN: 1341-7738</identifier><identifier>EISSN: 1347-5878</identifier><identifier>DOI: 10.1274/jmor.16.148</identifier><language>eng</language><publisher>Fujisawa: Japan Science and Technology Agency</publisher><subject>ANDROGENE ; ANDROGENOS ; ANDROGENS ; BIOLOGICAL DEVELOPMENT ; CULTIVO DE ORGANOS ; CULTURE D'ORGANE ; DESARROLLO BIOLOGICO ; DEVELOPPEMENT BIOLOGIQUE ; FOLICULOS OVARICOS ; FOLLICULE OVARIEN ; MICE ; ORGAN CULTURE ; OVAIRE ; OVARIAN FOLLICLES ; OVARIES ; OVARIOS ; RATON ; SOURIS</subject><ispartof>Journal of mammalian ova research, 1999, Vol.16 (3), p.148-153</ispartof><rights>Copyright Japan Science and Technology Agency 1999</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3138-5449a2dfe2e068ba47ba0de57f81a9cb5bafc894e91defa94d11e6ad221cb63f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,4025,27928,27929,27930</link.rule.ids></links><search><creatorcontrib>Ikeda, Y. 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These results suggest that androgens directly promote proliferation of granulosa cells in early developing mouse follicles in vitro.</description><subject>ANDROGENE</subject><subject>ANDROGENOS</subject><subject>ANDROGENS</subject><subject>BIOLOGICAL DEVELOPMENT</subject><subject>CULTIVO DE ORGANOS</subject><subject>CULTURE D'ORGANE</subject><subject>DESARROLLO BIOLOGICO</subject><subject>DEVELOPPEMENT BIOLOGIQUE</subject><subject>FOLICULOS OVARICOS</subject><subject>FOLLICULE OVARIEN</subject><subject>MICE</subject><subject>ORGAN CULTURE</subject><subject>OVAIRE</subject><subject>OVARIAN FOLLICLES</subject><subject>OVARIES</subject><subject>OVARIOS</subject><subject>RATON</subject><subject>SOURIS</subject><issn>1341-7738</issn><issn>1347-5878</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><recordid>eNotkM1LxDAQxYMouK6ePAsBj9I106RNepTFTxb0oF5DmkyWLm2zJtuF_e9tXecy8-A378Ej5BrYAnIp7jddiAsoFyDUCZkBFzIrlFSnfzdkUnJ1Ti5S2jAmlGJyRr4fvUe7SzR4anoXwxr7UfQUTWwP1OEe27DtsN9NRBeGhNSHtm1si4k2PQ1xbfrMDu1uiOho2JvYYLokZ960Ca_-95x8PT1-Ll-y1fvz6_JhlVkOXGWFEJXJncccWalqI2RtmMNCegWmsnVRG29VJbACh95UwgFgaVyeg61L7vmc3B59tzH8DJh2ehOG2I-RGoTgpVSl4CN1d6RsDClF9Hobm87Egwamp-L0VJyGcnxSI31zpL0J2qxjk_TbR86mAVEo_gug1mu4</recordid><startdate>1999</startdate><enddate>1999</enddate><creator>Ikeda, Y. 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| ispartof | Journal of mammalian ova research, 1999, Vol.16 (3), p.148-153 |
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| language | eng |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; AgriKnowledge（アグリナレッジ）AGROLib |
| subjects | ANDROGENE ANDROGENOS ANDROGENS BIOLOGICAL DEVELOPMENT CULTIVO DE ORGANOS CULTURE D'ORGANE DESARROLLO BIOLOGICO DEVELOPPEMENT BIOLOGIQUE FOLICULOS OVARICOS FOLLICULE OVARIEN MICE ORGAN CULTURE OVAIRE OVARIAN FOLLICLES OVARIES OVARIOS RATON SOURIS |
| title | Effects of androgens on early development of mouse follicles in organ-cultured ovaries |
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