Antihyperglycemic Effect of Mangiferin in Streptozotocin Induced Diabetic Rats

The study was undertaken to evaluate the antihyperglycemic potential of mangiferin purified from methanolic root extract of Salacia chinensis (S. chinensis) in control and streptozotocin (STZ)-induced diabetic rats. The mangiferin was administered orally at a dose of 40 mg/kg weight per day (30 days) to STZ-induced diabetic rats. The mangiferin treated diabetic rats significantly decreased the level of blood glucose, glycosylated hemoglobin as well as increased level of insulin and hemoglobin. The activities of hexokinase, pyruvate kinase, glucose-6-phosphate dehydrogenase, glycogen synthase, and glycogen content level were increased to near normal in mangiferin treated diabetic rats. The activities of lactate dehydrogenase, glucose-6-phosphatase, fructose-1,6-diphosphatase and glycogen phosphorylase were significantly decreased in liver tissue of diabetic treated rats. These findings demonstrated that mangiferin possess antidiabetic activity against STZ-induced diabetic rats. The antidiabetic effect of mangiferin was compared with standard antidiabetic drug glibenclamide.