Novel Topical Ophthalmic Formulations for Management of Glaucoma

ABSTRACT Purpose Preparation of topical ophthalmic formulations containing brimonidine-loaded nanoparticles prepared from various biodegradable polymers—PCL, PLA and PLGA—for sustained release of brimonidine as a once daily regimen for management of glaucoma. Methods Nanoparticles were prepared usin...

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Veröffentlicht in:	Pharmaceutical research 2013-11, Vol.30 (11), p.2818-2831
Hauptverfasser:	Ibrahim, Mohammed M., Abd-Elgawad, Abd-Elgawad H., Soliman, Osama A., Jablonski, Monica M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic alpha-2 Receptor Agonists - administration & dosage Animals Biochemistry Biodegradation Biological and medical sciences Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Brimonidine Tartrate Cytotoxicity Glaucoma Glaucoma - drug therapy Glaucoma and intraocular pressure Lactic Acid - chemistry Medical Law Medical sciences Mice Nanoparticles Nanoparticles - chemistry Ophthalmic Solutions - chemistry Ophthalmology Pharmacology. Drug treatments Pharmacology/Toxicology Pharmacy Polyesters - chemistry Polyglycolic Acid - chemistry Polymers Quinoxalines - administration & dosage Research Paper
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