Omeprazole and PGC-Formulated Heparin Binding Epidermal Growth Factor Normalizes Fasting Blood Glucose and Suppresses Insulitis in Multiple Low Dose Streptozotocin Diabetes Model

ABSTRACT Purpose Our objective was to develop novel nanocarriers (protected graft copolymer, PGC) that improve the stability of heparin binding EGF (HBEGF) and gastrin and then to use PGC-formulated HBEGF (PGC-HBEGF) and Omeprazole (+/− PGC-gastrin) for normalizing fasting blood glucose (FBG) and im...

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Veröffentlicht in:	Pharmaceutical research 2013-11, Vol.30 (11), p.2843-2854
Hauptverfasser:	Castillo, Gerardo M., Nishimoto-Ashfield, Akiko, Banerjee, Aryamitra A., Landolfi, Jennifer A., Lyubimov, Alexander V., Bolotin, Elijah M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry Biological and medical sciences Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Blood Glucose - analysis Copolymers Diabetes Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - pathology Diabetes. Impaired glucose tolerance Drug Carriers - chemistry Endocrine pancreas. Apud cells (diseases) Endocrinopathies Epidermal growth factor Etiopathogenesis. Screening. Investigations. Target tissue resistance Gastrins - administration & dosage Gastrins - pharmacokinetics Gastrins - therapeutic use Glucose Heparin-binding EGF-like Growth Factor Intercellular Signaling Peptides and Proteins - administration & dosage Intercellular Signaling Peptides and Proteins - pharmacokinetics Intercellular Signaling Peptides and Proteins - therapeutic use Male Medical Law Medical sciences Mice Nanostructures - chemistry Omeprazole - administration & dosage Omeprazole - pharmacokinetics Omeprazole - therapeutic use Pancreas - drug effects Pancreas - pathology Pharmacology Pharmacology. Drug treatments Pharmacology/Toxicology Pharmacy Polymers - chemistry Research Paper Streptozocin
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