Synthesis and Cytotoxic Activity of Salicyloyl Hydrazone Derivatives
Three salicyloyl hydrazone derivatives (compounds 1-3) were prepared by reacting salicyloyl hydrazine with substituted formaldehydes. Their structures were characterized by melting point, 1H-NMR, ESI-MS and elemental analyses. The cytotoxic activity of compounds 1-3 was evaluated in vitro against He...
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| Veröffentlicht in: | Applied Mechanics and Materials 2013-05, Vol.320, p.522-525 |
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| container_title | Applied Mechanics and Materials |
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| creator | Qiu, Xiao Yang Zhang, Xiao Li Shi, An Ran |
| description | Three salicyloyl hydrazone derivatives (compounds 1-3) were prepared by reacting salicyloyl hydrazine with substituted formaldehydes. Their structures were characterized by melting point, 1H-NMR, ESI-MS and elemental analyses. The cytotoxic activity of compounds 1-3 was evaluated in vitro against Hela cells (human cervical cancer cells). The results revealed that all the compounds showed cytotoxic activity, with IC50 values lower than 15 μM. |
| doi_str_mv | 10.4028/www.scientific.net/AMM.320.522 |
| format | Article |
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Their structures were characterized by melting point, 1H-NMR, ESI-MS and elemental analyses. The cytotoxic activity of compounds 1-3 was evaluated in vitro against Hela cells (human cervical cancer cells). The results revealed that all the compounds showed cytotoxic activity, with IC50 values lower than 15 μM.</description><identifier>ISSN: 1660-9336</identifier><identifier>ISSN: 1662-7482</identifier><identifier>ISBN: 9783037856857</identifier><identifier>ISBN: 3037856858</identifier><identifier>EISSN: 1662-7482</identifier><identifier>DOI: 10.4028/www.scientific.net/AMM.320.522</identifier><language>eng</language><publisher>Zurich: Trans Tech Publications Ltd</publisher><ispartof>Applied Mechanics and Materials, 2013-05, Vol.320, p.522-525</ispartof><rights>2013 Trans Tech Publications Ltd</rights><rights>Copyright Trans Tech Publications Ltd. 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| title | Synthesis and Cytotoxic Activity of Salicyloyl Hydrazone Derivatives |
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