Synthesis and Cytotoxic Activity of Salicyloyl Hydrazone Derivatives

Synthesis and Cytotoxic Activity of Salicyloyl Hydrazone Derivatives

Three salicyloyl hydrazone derivatives (compounds 1-3) were prepared by reacting salicyloyl hydrazine with substituted formaldehydes. Their structures were characterized by melting point, 1H-NMR, ESI-MS and elemental analyses. The cytotoxic activity of compounds 1-3 was evaluated in vitro against He...

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Veröffentlicht in:Applied Mechanics and Materials 2013-05, Vol.320, p.522-525
Hauptverfasser: Qiu, Xiao Yang, Zhang, Xiao Li, Shi, An Ran
Format: Artikel
Sprache:eng
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Zusammenfassung:Three salicyloyl hydrazone derivatives (compounds 1-3) were prepared by reacting salicyloyl hydrazine with substituted formaldehydes. Their structures were characterized by melting point, 1H-NMR, ESI-MS and elemental analyses. The cytotoxic activity of compounds 1-3 was evaluated in vitro against Hela cells (human cervical cancer cells). The results revealed that all the compounds showed cytotoxic activity, with IC50 values lower than 15 μM.
ISSN:1660-9336
1662-7482
1662-7482
DOI:10.4028/www.scientific.net/AMM.320.522