Protective Effect of Squalene against Isoproterenol-Induced Myocardial Infarction in Rats
The protective effect of squalene on membrane function and mineral status was examined in isoproterenol-induced myocardial infarction in male albino rats. The pretreatment with squalene at 2% level along with feed significantly reduced the isoproterenol-induced rise in the levels of plasma diagnosti...
Gespeichert in:
| Veröffentlicht in: | Journal of Clinical Biochemistry and Nutrition 2005, Vol.37(2), pp.55-60 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 60 |
|---|---|
| container_issue | 2 |
| container_start_page | 55 |
| container_title | Journal of Clinical Biochemistry and Nutrition |
| container_volume | 37 |
| creator | Farvin, Koduvayur Habeebullah Sabeena Anandan, Rangasamy Sankar, Thazhakot Vasunambisan Nair, Pullanniyil Gopalan Viswanathan |
| description | The protective effect of squalene on membrane function and mineral status was examined in isoproterenol-induced myocardial infarction in male albino rats. The pretreatment with squalene at 2% level along with feed significantly reduced the isoproterenol-induced rise in the levels of plasma diagnostic marker enzymes (ALT, AST, LDH and CPK). It counteracted isoproterenol-induced lipid peroxidation in plasma and heart tissue, and maintained the level of reduced glutathione in the heart tissue at near normalcy. Supplementation of squalene also exerted membrane stabilizing action against isoproterenol-induced myocardial infarction by maintaining the activities of membrane-bound ATPases (Na+, K+ ATPase and Ca2+ ATPase) in heart tissue and the mineral status (sodium, potassium and calcium) in plasma and heart tissue at near normal levels. The cardioprotective effect of squalene might be ascribable to its antioxidant nature and membrane stabilizing property. |
| doi_str_mv | 10.3164/jcbn.37.55 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_1441932597</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3098949781</sourcerecordid><originalsourceid>FETCH-LOGICAL-c542t-d92d058dfb75ccd3a838ca6c547b9e653aaee581511879ebfbbd9c8ee696686a3</originalsourceid><addsrcrecordid>eNo9kN1LwzAUxYMoOKcv_gUB34TOpGnS5Elk-DGYKH48-BRu09vZUtMt6YT993ZU9nLvhfPj3MMh5JKzmeAqu2lc4Wcin0l5RCZca5ZIptUxmTDD04QxZk7JWYwNY5mSKpuQr9fQ9ej6-hfpfVUNF-0q-r7ZQoseKayg9rGni9it92BA37XJwpdbhyV93nUOQllDSxe-gjDYdJ7Wnr5BH8_JSQVtxIv_PSWfD_cf86dk-fK4mN8tEyeztE9Kk5ZM6rIqculcKUAL7UANYl4YVFIAIErNJec6N1hURVEapxGVUUorEFNyNfoOATdbjL1tum3ww0vLs4wbkUqTD9T1SLnQxRiwsutQ_0DYWc7svjq7r86K3Eo5wLcj3MQeVnhAIfS1a_GApuOQ8qC4bwgWvfgDiZV6YA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1441932597</pqid></control><display><type>article</type><title>Protective Effect of Squalene against Isoproterenol-Induced Myocardial Infarction in Rats</title><source>J-STAGE Free</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Free Full-Text Journals in Chemistry</source><creator>Farvin, Koduvayur Habeebullah Sabeena ; Anandan, Rangasamy ; Sankar, Thazhakot Vasunambisan ; Nair, Pullanniyil Gopalan Viswanathan</creator><creatorcontrib>Farvin, Koduvayur Habeebullah Sabeena ; Anandan, Rangasamy ; Sankar, Thazhakot Vasunambisan ; Nair, Pullanniyil Gopalan Viswanathan</creatorcontrib><description>The protective effect of squalene on membrane function and mineral status was examined in isoproterenol-induced myocardial infarction in male albino rats. The pretreatment with squalene at 2% level along with feed significantly reduced the isoproterenol-induced rise in the levels of plasma diagnostic marker enzymes (ALT, AST, LDH and CPK). It counteracted isoproterenol-induced lipid peroxidation in plasma and heart tissue, and maintained the level of reduced glutathione in the heart tissue at near normalcy. Supplementation of squalene also exerted membrane stabilizing action against isoproterenol-induced myocardial infarction by maintaining the activities of membrane-bound ATPases (Na+, K+ ATPase and Ca2+ ATPase) in heart tissue and the mineral status (sodium, potassium and calcium) in plasma and heart tissue at near normal levels. The cardioprotective effect of squalene might be ascribable to its antioxidant nature and membrane stabilizing property.</description><identifier>ISSN: 0912-0009</identifier><identifier>EISSN: 1880-5086</identifier><identifier>DOI: 10.3164/jcbn.37.55</identifier><language>eng</language><publisher>Gifu: SOCIETY FOR FREE RADICAL RESEARCH JAPAN</publisher><subject>isoproterenol ; lipid peroxidation ; membrane-bound ATPases ; mineral status ; myocardial infarction ; squalene</subject><ispartof>Journal of Clinical Biochemistry and Nutrition, 2005, Vol.37(2), pp.55-60</ispartof><rights>2005 by The Editorial Secretariat of JCBN</rights><rights>Copyright Japan Science and Technology Agency 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c542t-d92d058dfb75ccd3a838ca6c547b9e653aaee581511879ebfbbd9c8ee696686a3</citedby><cites>FETCH-LOGICAL-c542t-d92d058dfb75ccd3a838ca6c547b9e653aaee581511879ebfbbd9c8ee696686a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids></links><search><creatorcontrib>Farvin, Koduvayur Habeebullah Sabeena</creatorcontrib><creatorcontrib>Anandan, Rangasamy</creatorcontrib><creatorcontrib>Sankar, Thazhakot Vasunambisan</creatorcontrib><creatorcontrib>Nair, Pullanniyil Gopalan Viswanathan</creatorcontrib><title>Protective Effect of Squalene against Isoproterenol-Induced Myocardial Infarction in Rats</title><title>Journal of Clinical Biochemistry and Nutrition</title><addtitle>J. Clin. Biochem. Nutr.</addtitle><description>The protective effect of squalene on membrane function and mineral status was examined in isoproterenol-induced myocardial infarction in male albino rats. The pretreatment with squalene at 2% level along with feed significantly reduced the isoproterenol-induced rise in the levels of plasma diagnostic marker enzymes (ALT, AST, LDH and CPK). It counteracted isoproterenol-induced lipid peroxidation in plasma and heart tissue, and maintained the level of reduced glutathione in the heart tissue at near normalcy. Supplementation of squalene also exerted membrane stabilizing action against isoproterenol-induced myocardial infarction by maintaining the activities of membrane-bound ATPases (Na+, K+ ATPase and Ca2+ ATPase) in heart tissue and the mineral status (sodium, potassium and calcium) in plasma and heart tissue at near normal levels. The cardioprotective effect of squalene might be ascribable to its antioxidant nature and membrane stabilizing property.</description><subject>isoproterenol</subject><subject>lipid peroxidation</subject><subject>membrane-bound ATPases</subject><subject>mineral status</subject><subject>myocardial infarction</subject><subject>squalene</subject><issn>0912-0009</issn><issn>1880-5086</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNo9kN1LwzAUxYMoOKcv_gUB34TOpGnS5Elk-DGYKH48-BRu09vZUtMt6YT993ZU9nLvhfPj3MMh5JKzmeAqu2lc4Wcin0l5RCZca5ZIptUxmTDD04QxZk7JWYwNY5mSKpuQr9fQ9ej6-hfpfVUNF-0q-r7ZQoseKayg9rGni9it92BA37XJwpdbhyV93nUOQllDSxe-gjDYdJ7Wnr5BH8_JSQVtxIv_PSWfD_cf86dk-fK4mN8tEyeztE9Kk5ZM6rIqculcKUAL7UANYl4YVFIAIErNJec6N1hURVEapxGVUUorEFNyNfoOATdbjL1tum3ww0vLs4wbkUqTD9T1SLnQxRiwsutQ_0DYWc7svjq7r86K3Eo5wLcj3MQeVnhAIfS1a_GApuOQ8qC4bwgWvfgDiZV6YA</recordid><startdate>20050101</startdate><enddate>20050101</enddate><creator>Farvin, Koduvayur Habeebullah Sabeena</creator><creator>Anandan, Rangasamy</creator><creator>Sankar, Thazhakot Vasunambisan</creator><creator>Nair, Pullanniyil Gopalan Viswanathan</creator><general>SOCIETY FOR FREE RADICAL RESEARCH JAPAN</general><general>Japan Science and Technology Agency</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7TK</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope></search><sort><creationdate>20050101</creationdate><title>Protective Effect of Squalene against Isoproterenol-Induced Myocardial Infarction in Rats</title><author>Farvin, Koduvayur Habeebullah Sabeena ; Anandan, Rangasamy ; Sankar, Thazhakot Vasunambisan ; Nair, Pullanniyil Gopalan Viswanathan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c542t-d92d058dfb75ccd3a838ca6c547b9e653aaee581511879ebfbbd9c8ee696686a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>isoproterenol</topic><topic>lipid peroxidation</topic><topic>membrane-bound ATPases</topic><topic>mineral status</topic><topic>myocardial infarction</topic><topic>squalene</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Farvin, Koduvayur Habeebullah Sabeena</creatorcontrib><creatorcontrib>Anandan, Rangasamy</creatorcontrib><creatorcontrib>Sankar, Thazhakot Vasunambisan</creatorcontrib><creatorcontrib>Nair, Pullanniyil Gopalan Viswanathan</creatorcontrib><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>Journal of Clinical Biochemistry and Nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Farvin, Koduvayur Habeebullah Sabeena</au><au>Anandan, Rangasamy</au><au>Sankar, Thazhakot Vasunambisan</au><au>Nair, Pullanniyil Gopalan Viswanathan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protective Effect of Squalene against Isoproterenol-Induced Myocardial Infarction in Rats</atitle><jtitle>Journal of Clinical Biochemistry and Nutrition</jtitle><addtitle>J. Clin. Biochem. Nutr.</addtitle><date>2005-01-01</date><risdate>2005</risdate><volume>37</volume><issue>2</issue><spage>55</spage><epage>60</epage><pages>55-60</pages><issn>0912-0009</issn><eissn>1880-5086</eissn><abstract>The protective effect of squalene on membrane function and mineral status was examined in isoproterenol-induced myocardial infarction in male albino rats. The pretreatment with squalene at 2% level along with feed significantly reduced the isoproterenol-induced rise in the levels of plasma diagnostic marker enzymes (ALT, AST, LDH and CPK). It counteracted isoproterenol-induced lipid peroxidation in plasma and heart tissue, and maintained the level of reduced glutathione in the heart tissue at near normalcy. Supplementation of squalene also exerted membrane stabilizing action against isoproterenol-induced myocardial infarction by maintaining the activities of membrane-bound ATPases (Na+, K+ ATPase and Ca2+ ATPase) in heart tissue and the mineral status (sodium, potassium and calcium) in plasma and heart tissue at near normal levels. The cardioprotective effect of squalene might be ascribable to its antioxidant nature and membrane stabilizing property.</abstract><cop>Gifu</cop><pub>SOCIETY FOR FREE RADICAL RESEARCH JAPAN</pub><doi>10.3164/jcbn.37.55</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0912-0009 |
| ispartof | Journal of Clinical Biochemistry and Nutrition, 2005, Vol.37(2), pp.55-60 |
| issn | 0912-0009 1880-5086 |
| language | eng |
| recordid | cdi_proquest_journals_1441932597 |
| source | J-STAGE Free; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Free Full-Text Journals in Chemistry |
| subjects | isoproterenol lipid peroxidation membrane-bound ATPases mineral status myocardial infarction squalene |
| title | Protective Effect of Squalene against Isoproterenol-Induced Myocardial Infarction in Rats |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T06%3A16%3A33IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Protective%20Effect%20of%20Squalene%20against%20Isoproterenol-Induced%20Myocardial%20Infarction%20in%20Rats&rft.jtitle=Journal%20of%20Clinical%20Biochemistry%20and%20Nutrition&rft.au=Farvin,%20Koduvayur%20Habeebullah%20Sabeena&rft.date=2005-01-01&rft.volume=37&rft.issue=2&rft.spage=55&rft.epage=60&rft.pages=55-60&rft.issn=0912-0009&rft.eissn=1880-5086&rft_id=info:doi/10.3164/jcbn.37.55&rft_dat=%3Cproquest_cross%3E3098949781%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1441932597&rft_id=info:pmid/&rfr_iscdi=true |