Effect of Muthu Marunthu (a Herbal Formulation) on the Altered Antioxidant Status in Experimental Fibrosarcoma in Rats
Muthu Marunthu, a herbal formulation, was used to study its anticancer effect on 3-methylcholanthrene-induced fibrosarcoma in rats. The effects of Muthu Marunthu on the tumor weight, on the activities of glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), and catalase (CAT), and on the leve...
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| Veröffentlicht in: | Journal of Clinical Biochemistry and Nutrition 1998, Vol.25(1), pp.41-48 |
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| container_title | Journal of Clinical Biochemistry and Nutrition |
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| creator | PALANI, Venugopal SENTHILKUMARAN, Kesavan SUBRAMANIAN, Sorimuthu GOVINDASAMY, Saminathan |
| description | Muthu Marunthu, a herbal formulation, was used to study its anticancer effect on 3-methylcholanthrene-induced fibrosarcoma in rats. The effects of Muthu Marunthu on the tumor weight, on the activities of glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), and catalase (CAT), and on the levels of lipid peroxide and glutathione (GSH) of liver and kidney were studied in the fibrosarcoma-bearing rats. The tumor weight was found to be reduced by the Muthu Marunthu treatment. In liver and kidney, the level of GSH and the activities of antioxidant enzymes such as GSH-Px, SOD, and CAT were decreased significantly, whereas the lipid peroxide content was increased significantly in fibrosarcoma rats. After Muthu Marunthu treatment, the GSH content and the activities of antioxidant enzymes were increased significantly with a concomitant decrease in the level of lipid peroxide. These observations clearly suggest that Muthu Marunthu can effectively normalize the fibrosarcoma-induced alterations to the antioxidant defense systems. |
| doi_str_mv | 10.3164/jcbn.25.41 |
| format | Article |
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The effects of Muthu Marunthu on the tumor weight, on the activities of glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), and catalase (CAT), and on the levels of lipid peroxide and glutathione (GSH) of liver and kidney were studied in the fibrosarcoma-bearing rats. The tumor weight was found to be reduced by the Muthu Marunthu treatment. In liver and kidney, the level of GSH and the activities of antioxidant enzymes such as GSH-Px, SOD, and CAT were decreased significantly, whereas the lipid peroxide content was increased significantly in fibrosarcoma rats. After Muthu Marunthu treatment, the GSH content and the activities of antioxidant enzymes were increased significantly with a concomitant decrease in the level of lipid peroxide. These observations clearly suggest that Muthu Marunthu can effectively normalize the fibrosarcoma-induced alterations to the antioxidant defense systems.</description><identifier>ISSN: 0912-0009</identifier><identifier>EISSN: 1880-5086</identifier><identifier>DOI: 10.3164/jcbn.25.41</identifier><language>eng</language><publisher>Tokyo: SOCIETY FOR FREE RADICAL RESEARCH JAPAN</publisher><subject>anticancer effect ; antioxidant systems ; Biological and medical sciences ; fibrosarcoma ; General pharmacology ; Medical sciences ; Muthu Marunthu (a herbal formulation) ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. 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Clin. Biochem. Nutr.</addtitle><description>Muthu Marunthu, a herbal formulation, was used to study its anticancer effect on 3-methylcholanthrene-induced fibrosarcoma in rats. The effects of Muthu Marunthu on the tumor weight, on the activities of glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), and catalase (CAT), and on the levels of lipid peroxide and glutathione (GSH) of liver and kidney were studied in the fibrosarcoma-bearing rats. The tumor weight was found to be reduced by the Muthu Marunthu treatment. In liver and kidney, the level of GSH and the activities of antioxidant enzymes such as GSH-Px, SOD, and CAT were decreased significantly, whereas the lipid peroxide content was increased significantly in fibrosarcoma rats. After Muthu Marunthu treatment, the GSH content and the activities of antioxidant enzymes were increased significantly with a concomitant decrease in the level of lipid peroxide. These observations clearly suggest that Muthu Marunthu can effectively normalize the fibrosarcoma-induced alterations to the antioxidant defense systems.</description><subject>anticancer effect</subject><subject>antioxidant systems</subject><subject>Biological and medical sciences</subject><subject>fibrosarcoma</subject><subject>General pharmacology</subject><subject>Medical sciences</subject><subject>Muthu Marunthu (a herbal formulation)</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. 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Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PALANI, Venugopal</creatorcontrib><creatorcontrib>SENTHILKUMARAN, Kesavan</creatorcontrib><creatorcontrib>SUBRAMANIAN, Sorimuthu</creatorcontrib><creatorcontrib>GOVINDASAMY, Saminathan</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>Journal of Clinical Biochemistry and Nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>PALANI, Venugopal</au><au>SENTHILKUMARAN, Kesavan</au><au>SUBRAMANIAN, Sorimuthu</au><au>GOVINDASAMY, Saminathan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Muthu Marunthu (a Herbal Formulation) on the Altered Antioxidant Status in Experimental Fibrosarcoma in Rats</atitle><jtitle>Journal of Clinical Biochemistry and Nutrition</jtitle><addtitle>J. Clin. Biochem. Nutr.</addtitle><date>1998-01-01</date><risdate>1998</risdate><volume>25</volume><issue>1</issue><spage>41</spage><epage>48</epage><pages>41-48</pages><issn>0912-0009</issn><eissn>1880-5086</eissn><abstract>Muthu Marunthu, a herbal formulation, was used to study its anticancer effect on 3-methylcholanthrene-induced fibrosarcoma in rats. The effects of Muthu Marunthu on the tumor weight, on the activities of glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), and catalase (CAT), and on the levels of lipid peroxide and glutathione (GSH) of liver and kidney were studied in the fibrosarcoma-bearing rats. The tumor weight was found to be reduced by the Muthu Marunthu treatment. In liver and kidney, the level of GSH and the activities of antioxidant enzymes such as GSH-Px, SOD, and CAT were decreased significantly, whereas the lipid peroxide content was increased significantly in fibrosarcoma rats. 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| subjects | anticancer effect antioxidant systems Biological and medical sciences fibrosarcoma General pharmacology Medical sciences Muthu Marunthu (a herbal formulation) Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments |
| title | Effect of Muthu Marunthu (a Herbal Formulation) on the Altered Antioxidant Status in Experimental Fibrosarcoma in Rats |
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