Insulin-Like Effect of Sodium Orthovanadate on Urea-Cycle Enzymes in Streptozotocin Diabetic Rats
Protein catabolism and the elimination of urea nitrogen increase in the diabetic condition. The mechanism involved in these increases was clarified by studying the levels of enzymes connected to the urea cycle. As vanadium in the form of sodium orthovanadate has been shown to possess insulin-like pr...
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| Veröffentlicht in: | Journal of Clinical Biochemistry and Nutrition 1994, Vol.16(3), pp.187-192 |
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| container_title | Journal of Clinical Biochemistry and Nutrition |
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| creator | MANEEMEGALAI, Sivaprakasam SEKAR, Natesan GOVINDASAMY, Saminathan |
| description | Protein catabolism and the elimination of urea nitrogen increase in the diabetic condition. The mechanism involved in these increases was clarified by studying the levels of enzymes connected to the urea cycle. As vanadium in the form of sodium orthovanadate has been shown to possess insulin-like properties, its effect on urea-cycle enzymes were studied. Male Wistar rats were made diabetic by streptozotocin, and the diabetic rats were then treated with sodium orthovanadate for 15 days. The altered blood glucose, urea, and activities of liver urea-cycle enzymes such as ornithine transcarbamoylase, arginosuccinase, arginase, aspartate transaminase, and alanine transaminase seen in the diabetic rats were found to be normalized in the sodium orthovanadate-treated diabetic animals. These results indicate the beneficial effect of sodium orthovanadate on experimental diabetes. |
| doi_str_mv | 10.3164/jcbn.16.187 |
| format | Article |
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The mechanism involved in these increases was clarified by studying the levels of enzymes connected to the urea cycle. As vanadium in the form of sodium orthovanadate has been shown to possess insulin-like properties, its effect on urea-cycle enzymes were studied. Male Wistar rats were made diabetic by streptozotocin, and the diabetic rats were then treated with sodium orthovanadate for 15 days. The altered blood glucose, urea, and activities of liver urea-cycle enzymes such as ornithine transcarbamoylase, arginosuccinase, arginase, aspartate transaminase, and alanine transaminase seen in the diabetic rats were found to be normalized in the sodium orthovanadate-treated diabetic animals. These results indicate the beneficial effect of sodium orthovanadate on experimental diabetes.</description><identifier>ISSN: 0912-0009</identifier><identifier>EISSN: 1880-5086</identifier><identifier>DOI: 10.3164/jcbn.16.187</identifier><language>eng</language><publisher>Tokyo: SOCIETY FOR FREE RADICAL RESEARCH JAPAN</publisher><subject>Biological and medical sciences ; diabetes ; General and cellular metabolism. Vitamins ; glucose ; Medical sciences ; Pharmacology. Drug treatments ; urea-cycle enzymes ; vanadium</subject><ispartof>Journal of Clinical Biochemistry and Nutrition, 1994, Vol.16(3), pp.187-192</ispartof><rights>The Editorial Secretariat of JCBN</rights><rights>1995 INIST-CNRS</rights><rights>Copyright Japan Science and Technology Agency 1994</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c553t-59f0db2d5592ed19775183a56c8ab2edc387db05e70a0d90012ab0e87fa3dd2f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3352698$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>MANEEMEGALAI, Sivaprakasam</creatorcontrib><creatorcontrib>SEKAR, Natesan</creatorcontrib><creatorcontrib>GOVINDASAMY, Saminathan</creatorcontrib><title>Insulin-Like Effect of Sodium Orthovanadate on Urea-Cycle Enzymes in Streptozotocin Diabetic Rats</title><title>Journal of Clinical Biochemistry and Nutrition</title><addtitle>J. Clin. Biochem. Nutr.</addtitle><description>Protein catabolism and the elimination of urea nitrogen increase in the diabetic condition. The mechanism involved in these increases was clarified by studying the levels of enzymes connected to the urea cycle. As vanadium in the form of sodium orthovanadate has been shown to possess insulin-like properties, its effect on urea-cycle enzymes were studied. Male Wistar rats were made diabetic by streptozotocin, and the diabetic rats were then treated with sodium orthovanadate for 15 days. The altered blood glucose, urea, and activities of liver urea-cycle enzymes such as ornithine transcarbamoylase, arginosuccinase, arginase, aspartate transaminase, and alanine transaminase seen in the diabetic rats were found to be normalized in the sodium orthovanadate-treated diabetic animals. These results indicate the beneficial effect of sodium orthovanadate on experimental diabetes.</description><subject>Biological and medical sciences</subject><subject>diabetes</subject><subject>General and cellular metabolism. Vitamins</subject><subject>glucose</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>urea-cycle enzymes</subject><subject>vanadium</subject><issn>0912-0009</issn><issn>1880-5086</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><recordid>eNo9kF2LEzEUhoMoWFev_AMBvZPpnkwmmcyldFd3obDgutfhTD7cqdOkJqnQ_fWmtvTmhJP3yRt4CPnIYMmZ7K43ZgxLJpdM9a_IgikFjQAlX5MFDKxtAGB4S97lvAHopJDdguB9yPt5Cs16-u3orffOFBo9fYx22m_pQyrP8S8GtFgcjYE-JYfN6mDmCoeXw9ZlOgX6WJLblfgSSzR1vZlwdGUy9AeW_J688Thn9-F8XpGnb7c_V3fN-uH7_errujFC8NKIwYMdWyvE0DrLhr4XTHEU0igc643hqrcjCNcDgh0AWIsjONV75Na2nl-RT6feXYp_9i4XvYn7FOqXmnVdddH3DCr15USZFHNOzutdmraYDpqBPjrUR4eaSV0dVvrzuROzwdknDGbKlyeci1YOqmI3J2yTC_5ylxxTlTC7_5VsUPJYy89D9ZfYPGPSLvB_vK2KLw</recordid><startdate>1994</startdate><enddate>1994</enddate><creator>MANEEMEGALAI, Sivaprakasam</creator><creator>SEKAR, Natesan</creator><creator>GOVINDASAMY, Saminathan</creator><general>SOCIETY FOR FREE RADICAL RESEARCH JAPAN</general><general>Institute of Applied Biochemistry</general><general>Japan Science and Technology Agency</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7TK</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope></search><sort><creationdate>1994</creationdate><title>Insulin-Like Effect of Sodium Orthovanadate on Urea-Cycle Enzymes in Streptozotocin Diabetic Rats</title><author>MANEEMEGALAI, Sivaprakasam ; SEKAR, Natesan ; GOVINDASAMY, Saminathan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c553t-59f0db2d5592ed19775183a56c8ab2edc387db05e70a0d90012ab0e87fa3dd2f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Biological and medical sciences</topic><topic>diabetes</topic><topic>General and cellular metabolism. Vitamins</topic><topic>glucose</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>urea-cycle enzymes</topic><topic>vanadium</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MANEEMEGALAI, Sivaprakasam</creatorcontrib><creatorcontrib>SEKAR, Natesan</creatorcontrib><creatorcontrib>GOVINDASAMY, Saminathan</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>Journal of Clinical Biochemistry and Nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MANEEMEGALAI, Sivaprakasam</au><au>SEKAR, Natesan</au><au>GOVINDASAMY, Saminathan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Insulin-Like Effect of Sodium Orthovanadate on Urea-Cycle Enzymes in Streptozotocin Diabetic Rats</atitle><jtitle>Journal of Clinical Biochemistry and Nutrition</jtitle><addtitle>J. Clin. Biochem. Nutr.</addtitle><date>1994</date><risdate>1994</risdate><volume>16</volume><issue>3</issue><spage>187</spage><epage>192</epage><pages>187-192</pages><issn>0912-0009</issn><eissn>1880-5086</eissn><abstract>Protein catabolism and the elimination of urea nitrogen increase in the diabetic condition. The mechanism involved in these increases was clarified by studying the levels of enzymes connected to the urea cycle. As vanadium in the form of sodium orthovanadate has been shown to possess insulin-like properties, its effect on urea-cycle enzymes were studied. Male Wistar rats were made diabetic by streptozotocin, and the diabetic rats were then treated with sodium orthovanadate for 15 days. The altered blood glucose, urea, and activities of liver urea-cycle enzymes such as ornithine transcarbamoylase, arginosuccinase, arginase, aspartate transaminase, and alanine transaminase seen in the diabetic rats were found to be normalized in the sodium orthovanadate-treated diabetic animals. These results indicate the beneficial effect of sodium orthovanadate on experimental diabetes.</abstract><cop>Tokyo</cop><pub>SOCIETY FOR FREE RADICAL RESEARCH JAPAN</pub><doi>10.3164/jcbn.16.187</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of Clinical Biochemistry and Nutrition, 1994, Vol.16(3), pp.187-192 |
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| language | eng |
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| source | J-STAGE Free; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Free Full-Text Journals in Chemistry |
| subjects | Biological and medical sciences diabetes General and cellular metabolism. Vitamins glucose Medical sciences Pharmacology. Drug treatments urea-cycle enzymes vanadium |
| title | Insulin-Like Effect of Sodium Orthovanadate on Urea-Cycle Enzymes in Streptozotocin Diabetic Rats |
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